Reconstitution of oogenesis in vitro provides a useful tool for improving our understanding of oogenesis and also an alternative source of oocytes for reproduction. In mice, it has become possible to produce fully mature oocytes from pluripotent stem cells (PSCs) in culture. The PSC-derived oocytes fertilized with wild-type sperm are capable of giving rise to pups that grow to fertile adult mice. This section describes how to reconstitute oogenesis in vitro including technical backgrounds, similarity and difference between in vivo and in vitro oogenesis, and a current situation of the application to humans.
|Title of host publication||Encyclopedia of Reproduction|
|Number of pages||7|
|Publication status||Published - Jan 1 2018|
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