Open-source cell extension system assembled from laser-cut plates

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Biological response of cells to mechanical stimulation plays an important role in regulation of cell activity, and thus has been an attracting topic for researchers in the field of biomechanics for many years. Stretching is the most common type of the mechanical stimulus that has been used for in vitro experiments. The device for application of stretching to cells has commercially been available for more than three decades. Although these ready-made devices will bring a smooth start of research work, they cost several thousands to tens of thousands dollars for introduction. Therefore, this study proposes an open-source self-made cell extension system which can be built at one tenth to one hundredth of the price of commercial devices. To reduce the difficulty of machining, the device was designed to be assembled from acrylic plates fabricated only by using a laser cutter without machining such as drilling or screw thread cutting. All other mechanical elements and electrical components are purchased from web shops. The accuracy of the reciprocating motion was verified with the fabricated device and an elastic silicone container for cell culture.

Original languageEnglish
Article numbere00065
JournalHardwareX
Volume5
DOIs
Publication statusPublished - Apr 1 2019

Fingerprint

Stretching
Machining
Thread cutting
Biomechanics
Lasers
cells
Cell culture
Silicones
Acrylics
lasers
Containers
Drilling
machining
Cells
biodynamics
cutters
shops
threads
Costs
screws

All Science Journal Classification (ASJC) codes

  • Civil and Structural Engineering
  • Biomedical Engineering
  • Instrumentation
  • Mechanical Engineering
  • Industrial and Manufacturing Engineering

Cite this

Open-source cell extension system assembled from laser-cut plates. / Kurata, Kosaku; Sumida, Keita; Takamatsu, Hiroshi.

In: HardwareX, Vol. 5, e00065, 01.04.2019.

Research output: Contribution to journalArticle

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