Opposite effects of alternative TZF spliced variants on androgen receptor

Rong Hua Tao, Hisaya Kawate, Keizo Ohnaka, Masamichi Ishizuka, Hiromi Hagiwara, Ryoichi Takayanagi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We previously demonstrated that testicular zinc-finger protein (TZF) was a corepressor of the androgen receptor (AR). In the present study, we further showed that TZF-L, an alternative spliced variant of TZF, enhanced transactivation function of AR. Deletion analysis of TZF-L revealed that its N-terminus, which almost corresponded to that of TZF, but not its C-terminus was able to interact with AR. Additional analysis suggested that TZF and TZF-L were able to form both homodimers and heterodimers. TZF-L inhibited the homodimer formation of TZF and the intranuclear dot formation of TZF. We propose that in the unique regulation system of AR-mediated transactivation, two spliced isoforms of TZF act as coactivator and corepressor, respectively.

Original languageEnglish
Pages (from-to)515-521
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume341
Issue number2
DOIs
Publication statusPublished - Mar 10 2006

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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