Optimal control mode of a biochemical feedback system

Masahiro Okamoto, Katsuya Hayashi

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


An optimal feedback system for constant-value control of biochemical reaction system was investigated by computer simulations. A feedback system containing a cyclic enzyme system where two enzyme types share a substrate in a cyclic manner, was found to be the most reliable one. This feedback system has a capability to keep the stationary value of the end product at a desired level against not only exogenous substrate supply but also endogenous parametric disturbances. The cyclic enzyme system installed as a control element of this feedback system played the role of comparator in this feedback system. The control made of this feedback system was in good agreement with that of a system established by means of optimization technique based on the maximum principle. Also bang-bang control could be performed in this biochemical feedback system as well as in electrical one.

Original languageEnglish
Pages (from-to)315-321
Number of pages7
Issue number3-4
Publication statusPublished - 1983
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Applied Mathematics


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