Optimal control mode of a biochemical feedback system

Masahiro Okamoto, Katsuya Hayashi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

An optimal feedback system for constant-value control of biochemical reaction system was investigated by computer simulations. A feedback system containing a cyclic enzyme system where two enzyme types share a substrate in a cyclic manner, was found to be the most reliable one. This feedback system has a capability to keep the stationary value of the end product at a desired level against not only exogenous substrate supply but also endogenous parametric disturbances. The cyclic enzyme system installed as a control element of this feedback system played the role of comparator in this feedback system. The control made of this feedback system was in good agreement with that of a system established by means of optimization technique based on the maximum principle. Also bang-bang control could be performed in this biochemical feedback system as well as in electrical one.

Original languageEnglish
Pages (from-to)315-321
Number of pages7
JournalBioSystems
Volume16
Issue number3-4
DOIs
Publication statusPublished - Jan 1 1983

Fingerprint

Physiological Feedback
Feedback Systems
Optimal Control
Feedback
Enzymes
Substrate
Bang-bang Control
Maximum principle
Optimal System
Computer Simulation
Substrates
Maximum Principle
Optimization Techniques
Disturbance

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Applied Mathematics

Cite this

Optimal control mode of a biochemical feedback system. / Okamoto, Masahiro; Hayashi, Katsuya.

In: BioSystems, Vol. 16, No. 3-4, 01.01.1983, p. 315-321.

Research output: Contribution to journalArticle

Okamoto, Masahiro ; Hayashi, Katsuya. / Optimal control mode of a biochemical feedback system. In: BioSystems. 1983 ; Vol. 16, No. 3-4. pp. 315-321.
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