Optimal multi-phase three-dimensional fast imaging with steady-state free precession dynamic MRI and its clinical application to the diagnosis of hepatocellular carcinoma

Kenji Shinozaki, Hiroshi Honda, Kengo Yoshimitsu, Ken ichi Taguchi, Toshiro Kuroiwa, Hiroyuki Irie, Hitoshi Aibe, Akihiro Nishie, Tomohiro Nakayama, Mitsuo Shimada, Kouji Masuda

Research output: Contribution to journalArticle

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Abstract

Purpose: To determine the appropriate acquisition parameters for three-dimensional fast imaging with steady-state free precession (3D-FISP), to clarify the superiority of 3D-FISP to two-dimensional fast low-angle shot (2D-FLASH) on phantom study, and to clarify the clinical usefulness of 3D-FISP in diagnosing hepatocellular carcinoma (HCC). Materials and Methods: 3D-FISP images with varying flip angles were compared by using a phantom. Signal-to-noise ratios (SNRs) and contrast-enhancement ratios (CERs) were compared for the four two-dimensional fast low-angle shot (2D-FLASH) sequences and 3D-FISP sequences in a phantom. The optimal 3D-FISP dynamic study was compared with plain, post-contrast MR sequences used to study 78 HCC cases and analyzed according to histological grade. The 3D-FISP image obtained 30 sec after gadopentetate dimeglumine (Gd) administration was also compared with CT hepatic angiography (CTHA). Results: A 25° flip angle and double-dose Gd administration were appropriate for 3D-FISP dynamic study. CER was the highest with 3D-FISP, and SNR was higher in 3D-FISP than in 2D-FLASH images in a phantom with high Gd concentration. Among the 105 lesions, 103 (98%) were depicted on 3D-FISP images. The detection rate of HCC on 3D-FISP was higher than 95% for each histological grade. The vascularity of the tumors as determined by CTHA findings was correctly diagnosed on 3D-FISP in 80% of cases. Conclusion: In phantom study, 3D-FISP with double-dose Gd injection showed higher contrast than 2D-FLASH as a sequence for liver dynamic study. In clinical study, 3D-FISP is useful in the detection of HCC, regardless of tumor vascularity and histological grade.

Original languageEnglish
Pages (from-to)111-119
Number of pages9
JournalRadiation Medicine - Medical Imaging and Radiation Oncology
Volume20
Issue number3
Publication statusPublished - Jan 1 2002

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Three-Dimensional Imaging
precession
Hepatocellular Carcinoma
cancer
Magnetic Resonance Imaging
grade
angiography
shot
signal to noise ratios
tumors
Gadolinium DTPA
dosage
augmentation
plains
liver
lesions
acquisition
injection
interleukin-24
Signal-To-Noise Ratio

All Science Journal Classification (ASJC) codes

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Oncology

Cite this

Optimal multi-phase three-dimensional fast imaging with steady-state free precession dynamic MRI and its clinical application to the diagnosis of hepatocellular carcinoma. / Shinozaki, Kenji; Honda, Hiroshi; Yoshimitsu, Kengo; Taguchi, Ken ichi; Kuroiwa, Toshiro; Irie, Hiroyuki; Aibe, Hitoshi; Nishie, Akihiro; Nakayama, Tomohiro; Shimada, Mitsuo; Masuda, Kouji.

In: Radiation Medicine - Medical Imaging and Radiation Oncology, Vol. 20, No. 3, 01.01.2002, p. 111-119.

Research output: Contribution to journalArticle

Shinozaki, Kenji ; Honda, Hiroshi ; Yoshimitsu, Kengo ; Taguchi, Ken ichi ; Kuroiwa, Toshiro ; Irie, Hiroyuki ; Aibe, Hitoshi ; Nishie, Akihiro ; Nakayama, Tomohiro ; Shimada, Mitsuo ; Masuda, Kouji. / Optimal multi-phase three-dimensional fast imaging with steady-state free precession dynamic MRI and its clinical application to the diagnosis of hepatocellular carcinoma. In: Radiation Medicine - Medical Imaging and Radiation Oncology. 2002 ; Vol. 20, No. 3. pp. 111-119.
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abstract = "Purpose: To determine the appropriate acquisition parameters for three-dimensional fast imaging with steady-state free precession (3D-FISP), to clarify the superiority of 3D-FISP to two-dimensional fast low-angle shot (2D-FLASH) on phantom study, and to clarify the clinical usefulness of 3D-FISP in diagnosing hepatocellular carcinoma (HCC). Materials and Methods: 3D-FISP images with varying flip angles were compared by using a phantom. Signal-to-noise ratios (SNRs) and contrast-enhancement ratios (CERs) were compared for the four two-dimensional fast low-angle shot (2D-FLASH) sequences and 3D-FISP sequences in a phantom. The optimal 3D-FISP dynamic study was compared with plain, post-contrast MR sequences used to study 78 HCC cases and analyzed according to histological grade. The 3D-FISP image obtained 30 sec after gadopentetate dimeglumine (Gd) administration was also compared with CT hepatic angiography (CTHA). Results: A 25° flip angle and double-dose Gd administration were appropriate for 3D-FISP dynamic study. CER was the highest with 3D-FISP, and SNR was higher in 3D-FISP than in 2D-FLASH images in a phantom with high Gd concentration. Among the 105 lesions, 103 (98{\%}) were depicted on 3D-FISP images. The detection rate of HCC on 3D-FISP was higher than 95{\%} for each histological grade. The vascularity of the tumors as determined by CTHA findings was correctly diagnosed on 3D-FISP in 80{\%} of cases. Conclusion: In phantom study, 3D-FISP with double-dose Gd injection showed higher contrast than 2D-FLASH as a sequence for liver dynamic study. In clinical study, 3D-FISP is useful in the detection of HCC, regardless of tumor vascularity and histological grade.",
author = "Kenji Shinozaki and Hiroshi Honda and Kengo Yoshimitsu and Taguchi, {Ken ichi} and Toshiro Kuroiwa and Hiroyuki Irie and Hitoshi Aibe and Akihiro Nishie and Tomohiro Nakayama and Mitsuo Shimada and Kouji Masuda",
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T1 - Optimal multi-phase three-dimensional fast imaging with steady-state free precession dynamic MRI and its clinical application to the diagnosis of hepatocellular carcinoma

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AU - Honda, Hiroshi

AU - Yoshimitsu, Kengo

AU - Taguchi, Ken ichi

AU - Kuroiwa, Toshiro

AU - Irie, Hiroyuki

AU - Aibe, Hitoshi

AU - Nishie, Akihiro

AU - Nakayama, Tomohiro

AU - Shimada, Mitsuo

AU - Masuda, Kouji

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N2 - Purpose: To determine the appropriate acquisition parameters for three-dimensional fast imaging with steady-state free precession (3D-FISP), to clarify the superiority of 3D-FISP to two-dimensional fast low-angle shot (2D-FLASH) on phantom study, and to clarify the clinical usefulness of 3D-FISP in diagnosing hepatocellular carcinoma (HCC). Materials and Methods: 3D-FISP images with varying flip angles were compared by using a phantom. Signal-to-noise ratios (SNRs) and contrast-enhancement ratios (CERs) were compared for the four two-dimensional fast low-angle shot (2D-FLASH) sequences and 3D-FISP sequences in a phantom. The optimal 3D-FISP dynamic study was compared with plain, post-contrast MR sequences used to study 78 HCC cases and analyzed according to histological grade. The 3D-FISP image obtained 30 sec after gadopentetate dimeglumine (Gd) administration was also compared with CT hepatic angiography (CTHA). Results: A 25° flip angle and double-dose Gd administration were appropriate for 3D-FISP dynamic study. CER was the highest with 3D-FISP, and SNR was higher in 3D-FISP than in 2D-FLASH images in a phantom with high Gd concentration. Among the 105 lesions, 103 (98%) were depicted on 3D-FISP images. The detection rate of HCC on 3D-FISP was higher than 95% for each histological grade. The vascularity of the tumors as determined by CTHA findings was correctly diagnosed on 3D-FISP in 80% of cases. Conclusion: In phantom study, 3D-FISP with double-dose Gd injection showed higher contrast than 2D-FLASH as a sequence for liver dynamic study. In clinical study, 3D-FISP is useful in the detection of HCC, regardless of tumor vascularity and histological grade.

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