Optimization of post-label delay in single-phase arterial spin labeling (ASL) using multi-phase ASL in four-dimensional magnetic resonance angiography

Tsuyoshi Oshita, Hidetake Yabuuchi, Masanobu Osame

Research output: Contribution to journalArticle

Abstract

Purpose: To optimize the post-label delay in single-phase arterial spin labeling (SP-ASL) using multi-phase ASL in 4-dimensional magnetic resonance angiography (4D-MRA). Methods: Ten healthy volunteers (six men, four women; age range, 24–37 years; mean, 29.1) were enrolled. 4D-MRA and SP-ASL were performed on a 3T magnetic resonance imaging (MRI) scanner. Signal intensities in four cerebral arterial territories (anterior cerebral artery, middle cerebral artery, posterior cerebral artery, and whole area) were measured using both 4D-MRA and SP-ASL, and peak time of maximum intensity through each technique was recorded. Regression analysis was used to determine the correlation between the peak times using 4D-MRA and those using SP-ASL, and the regression function obtained was used to estimate the peak time for SP-ASL (optimum post-label delay) from that obtained for 4D-MRA. Results: The peak time in anterior cerebral artery territory for SP-ASL was expressed as 1.19 + 0.30 × (peak time of 4D-MRA) s, (p = 0.017, r2 = 0.14). The peak time in middle cerebral artery territory for SP-ASL was 0.96 + 0.58 × (peak time of 4D-MRA) s, (p < 0.001, r2 = 0.32). The peak time in posterior cerebral artery territory for SP-ASL was expressed as 0.92 + 0.58 × (peak time of 4D-MRA) s, (p < 0.001, r2 = 0.33). The peak time in whole brain for SP-ASL was expressed as 1.04 + 0.46 × (peak time of 4D-MRA) s, (p < 0.001, r2 = 0.25). Conclusion: The peak time values at 4D-MRA showed potential for use in predicting the optimum post-label delay of SP-ASL.

Original languageEnglish
Pages (from-to)173-178
Number of pages6
JournalNeuroradiology Journal
Volume32
Issue number3
DOIs
Publication statusPublished - Jun 1 2019

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Magnetic Resonance Angiography
Posterior Cerebral Artery
Anterior Cerebral Artery
Middle Cerebral Artery
Healthy Volunteers
Regression Analysis
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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Optimization of post-label delay in single-phase arterial spin labeling (ASL) using multi-phase ASL in four-dimensional magnetic resonance angiography. / Oshita, Tsuyoshi; Yabuuchi, Hidetake; Osame, Masanobu.

In: Neuroradiology Journal, Vol. 32, No. 3, 01.06.2019, p. 173-178.

Research output: Contribution to journalArticle

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abstract = "Purpose: To optimize the post-label delay in single-phase arterial spin labeling (SP-ASL) using multi-phase ASL in 4-dimensional magnetic resonance angiography (4D-MRA). Methods: Ten healthy volunteers (six men, four women; age range, 24–37 years; mean, 29.1) were enrolled. 4D-MRA and SP-ASL were performed on a 3T magnetic resonance imaging (MRI) scanner. Signal intensities in four cerebral arterial territories (anterior cerebral artery, middle cerebral artery, posterior cerebral artery, and whole area) were measured using both 4D-MRA and SP-ASL, and peak time of maximum intensity through each technique was recorded. Regression analysis was used to determine the correlation between the peak times using 4D-MRA and those using SP-ASL, and the regression function obtained was used to estimate the peak time for SP-ASL (optimum post-label delay) from that obtained for 4D-MRA. Results: The peak time in anterior cerebral artery territory for SP-ASL was expressed as 1.19 + 0.30 × (peak time of 4D-MRA) s, (p = 0.017, r2 = 0.14). The peak time in middle cerebral artery territory for SP-ASL was 0.96 + 0.58 × (peak time of 4D-MRA) s, (p < 0.001, r2 = 0.32). The peak time in posterior cerebral artery territory for SP-ASL was expressed as 0.92 + 0.58 × (peak time of 4D-MRA) s, (p < 0.001, r2 = 0.33). The peak time in whole brain for SP-ASL was expressed as 1.04 + 0.46 × (peak time of 4D-MRA) s, (p < 0.001, r2 = 0.25). Conclusion: The peak time values at 4D-MRA showed potential for use in predicting the optimum post-label delay of SP-ASL.",
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