Oral administration of bovine colostrum stimulates intestinal intraepithelial lymphocytes to polarize Th1-type in mice

Yasuko Yoshioka, Satsuki Kudo, Hitoshi Nishimura, Toshiki Yajima, Kenji Kishihara, Kimika Saito, Tatsuo Suzuki, Yumiko Suzuki, Shinsuke Kuroiwa, Yasunobu Yoshikai

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Abstract

    Th1 stimulus for Th2-skewed immune response during infancy is important for reduction of incidence of allergic diseases. We examined effects of oral administration of bovine colostrum on local immunity in intestine in adult mice. C57BL/6 mice were orally given bovine colostrum or control milk for 1, 3 or 6 months and intestinal microflora, fecal IgA, and lymphocyte population of gut-associated lymphoid tissues and their abilities of cytokine production were examined. Although the cell populations of intestinal intraepithelial lymphocytes (i-IEL) were not remarkably changed, the T cells in i-IEL were polarized to Th1 type after oral administration of bovine colostrum. Intestinal microflora and IgA levels in feces were not changed by oral administration of bovine colostrum. These results suggest that colostrum stimulates directly to i-IEL to polarize Th1 type, which may protect from infectious diseases and allergic diseases mediated by Th2 type responses.

    Original languageEnglish
    Pages (from-to)581-590
    Number of pages10
    JournalInternational Immunopharmacology
    Volume5
    Issue number3
    DOIs
    Publication statusPublished - Jan 1 2005

    Fingerprint

    Colostrum
    Oral Administration
    Lymphocytes
    Immunoglobulin A
    Lymphoid Tissue
    Inbred C57BL Mouse
    Feces
    Population
    Intestines
    Communicable Diseases
    Immunity
    Milk
    Cytokines
    T-Lymphocytes
    Incidence

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology
    • Pharmacology

    Cite this

    Oral administration of bovine colostrum stimulates intestinal intraepithelial lymphocytes to polarize Th1-type in mice. / Yoshioka, Yasuko; Kudo, Satsuki; Nishimura, Hitoshi; Yajima, Toshiki; Kishihara, Kenji; Saito, Kimika; Suzuki, Tatsuo; Suzuki, Yumiko; Kuroiwa, Shinsuke; Yoshikai, Yasunobu.

    In: International Immunopharmacology, Vol. 5, No. 3, 01.01.2005, p. 581-590.

    Research output: Contribution to journalArticle

    Yoshioka, Y, Kudo, S, Nishimura, H, Yajima, T, Kishihara, K, Saito, K, Suzuki, T, Suzuki, Y, Kuroiwa, S & Yoshikai, Y 2005, 'Oral administration of bovine colostrum stimulates intestinal intraepithelial lymphocytes to polarize Th1-type in mice', International Immunopharmacology, vol. 5, no. 3, pp. 581-590. https://doi.org/10.1016/j.intimp.2004.11.005
    Yoshioka, Yasuko ; Kudo, Satsuki ; Nishimura, Hitoshi ; Yajima, Toshiki ; Kishihara, Kenji ; Saito, Kimika ; Suzuki, Tatsuo ; Suzuki, Yumiko ; Kuroiwa, Shinsuke ; Yoshikai, Yasunobu. / Oral administration of bovine colostrum stimulates intestinal intraepithelial lymphocytes to polarize Th1-type in mice. In: International Immunopharmacology. 2005 ; Vol. 5, No. 3. pp. 581-590.
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