Oral administration of chicken breast extract activates serotonin metabolism in the hippocampus of rats

Shozo Tomonaga, Mikako Sato, Yoshihisa Takahata, Fumiki Morimatsu, Mitsuhiro Furuse

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We previously reported that Chicken Breast Extract (CBEX) had an antidepressant-like effect in rats. In the present study to further clarify, the mechanism of action of CBEX, the effects of CBEX on the brain serotonin (5-HT) system was investigated mthe ventral hippocampus of rats, using an in vivo micro dialysis. 5-Hydroxyindoleacetic acid, a major metabolite of serotonin, was significantly increased in animals orally administered CBEX. This result indicates that CBEX may activate 5-HT metabolism in the brain. Since, a previous study indicated that orally administered CBEX increases levels of the putative neurotransmitter carnosine in the hippocampus, carnosine might be involved in the action of CBEX.

Original languageEnglish
Pages (from-to)2276-2279
Number of pages4
JournalJournal of Animal and Veterinary Advances
Volume8
Issue number11
Publication statusPublished - 2009

All Science Journal Classification (ASJC) codes

  • Agronomy and Crop Science
  • veterinary(all)

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