TY - JOUR
T1 - Oral administration of chicken breast extract activates serotonin metabolism in the hippocampus of rats
AU - Tomonaga, Shozo
AU - Sato, Mikako
AU - Takahata, Yoshihisa
AU - Morimatsu, Fumiki
AU - Furuse, Mitsuhiro
PY - 2009
Y1 - 2009
N2 - We previously reported that Chicken Breast Extract (CBEX) had an antidepressant-like effect in rats. In the present study to further clarify, the mechanism of action of CBEX, the effects of CBEX on the brain serotonin (5-HT) system was investigated mthe ventral hippocampus of rats, using an in vivo micro dialysis. 5-Hydroxyindoleacetic acid, a major metabolite of serotonin, was significantly increased in animals orally administered CBEX. This result indicates that CBEX may activate 5-HT metabolism in the brain. Since, a previous study indicated that orally administered CBEX increases levels of the putative neurotransmitter carnosine in the hippocampus, carnosine might be involved in the action of CBEX.
AB - We previously reported that Chicken Breast Extract (CBEX) had an antidepressant-like effect in rats. In the present study to further clarify, the mechanism of action of CBEX, the effects of CBEX on the brain serotonin (5-HT) system was investigated mthe ventral hippocampus of rats, using an in vivo micro dialysis. 5-Hydroxyindoleacetic acid, a major metabolite of serotonin, was significantly increased in animals orally administered CBEX. This result indicates that CBEX may activate 5-HT metabolism in the brain. Since, a previous study indicated that orally administered CBEX increases levels of the putative neurotransmitter carnosine in the hippocampus, carnosine might be involved in the action of CBEX.
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M3 - Article
AN - SCOPUS:77951639235
SN - 1680-5593
VL - 8
SP - 2276
EP - 2279
JO - Journal of Animal and Veterinary Advances
JF - Journal of Animal and Veterinary Advances
IS - 11
ER -