Oral administration of chicken breast extract increases brain carnosine and anserine concentrations in rats

Shozo Tomonaga, Toru Hayakawa, Haruka Yamane, Hirohiko Maemura, Mikako Sato, Yoshihisa Takahata, Fumiki Morimatsu, Mitsuhiro Furuse

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Carnosine (β-alanyl-L-histidine) and its derivative anserine (β-alanyl-1-methyl-L-histidine) are antioxidants and putative neurotransmitters in the brain. These dipeptides are rich in the commercially available supplement chicken breast extract (CBEX). To clarify the effects of CBEX on the brain, we examined whether single oral administration of CBEX (20 ml/kg) affects brain dipeptide and free amino acid concentrations in male Wistar rats. CBEX significantly and time-dependently increased carnosine and anserine levels in the plasma (at 120 min after injection, increase rates were 2976 and 4142%, respectively), hippocampus (64 and 78%), and hypothalamus (188 and 120%), but not in cerebral cortex. Significant and time-dependent increases in citrulline in the hippocampus (49%) and hypothalamus (41%) demonstrated generation of nitric oxide due to the increased carnosine and/or anserine levels in these brain regions. These findings suggest that CBEX modifies brain functions by increasing levels of these dipeptides.

Original languageEnglish
Pages (from-to)181-186
Number of pages6
JournalNutritional Neuroscience
Volume10
Issue number3-4
DOIs
Publication statusPublished - Jun 1 2007

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Anserine
Carnosine
Oral Administration
Chickens
Breast
Dipeptides
Brain
Histidine
Hypothalamus
Hippocampus
Citrulline
Cerebral Cortex
Neurotransmitter Agents
Wistar Rats
Nitric Oxide
Antioxidants
Amino Acids
Injections

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Neuroscience(all)
  • Nutrition and Dietetics

Cite this

Oral administration of chicken breast extract increases brain carnosine and anserine concentrations in rats. / Tomonaga, Shozo; Hayakawa, Toru; Yamane, Haruka; Maemura, Hirohiko; Sato, Mikako; Takahata, Yoshihisa; Morimatsu, Fumiki; Furuse, Mitsuhiro.

In: Nutritional Neuroscience, Vol. 10, No. 3-4, 01.06.2007, p. 181-186.

Research output: Contribution to journalArticle

Tomonaga, S, Hayakawa, T, Yamane, H, Maemura, H, Sato, M, Takahata, Y, Morimatsu, F & Furuse, M 2007, 'Oral administration of chicken breast extract increases brain carnosine and anserine concentrations in rats', Nutritional Neuroscience, vol. 10, no. 3-4, pp. 181-186. https://doi.org/10.1080/10284150701587338
Tomonaga, Shozo ; Hayakawa, Toru ; Yamane, Haruka ; Maemura, Hirohiko ; Sato, Mikako ; Takahata, Yoshihisa ; Morimatsu, Fumiki ; Furuse, Mitsuhiro. / Oral administration of chicken breast extract increases brain carnosine and anserine concentrations in rats. In: Nutritional Neuroscience. 2007 ; Vol. 10, No. 3-4. pp. 181-186.
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