TY - JOUR
T1 - Oral administration of D-aspartate, but not of L-aspartate, reduces food intake in chicks
AU - Erwan, Edi
AU - Tomonaga, Shozo
AU - Ohmori, Taketo
AU - Mutaguchi, Yuta
AU - Ohshima, Toshihisa
AU - Nagasawa, Mao
AU - Yasuo, Shinobu
AU - Tamura, Yoshinaga
AU - Furuse, Mitsuhiro
PY - 2013
Y1 - 2013
N2 - In the present study, we determined the effects of oral administration of L-and D-aspartate (L-Asp and D-Asp) on food intake over a period of 2 h after the administration, as well as its effects on the concentration of L-and D-Asp in the brain and plasma. Chicks were orally administered different levels (0, 3.75, 7.5 and 15 mmol/kg body weight) of L-Asp (Experiment 1) and D-Asp (Experiment 2). Administration of several doses of L-Asp linearly increased the concentration of L-Asp, but not of D-Asp, in plasma. Oral L-Asp somewhat modified the levels of L-and D-Asp levels in the telencephalon, but not in the diencephalon. However, food intake was not significantly changed with doses of L-Asp. On the other hand, D-Asp strongly and dose-dependently inhibited food intake over a period of 2 h after the administration. Oral D-Asp clearly increased D-Asp levels in the plasma and diencephalon, but no significant changes in L-Asp were detected. Brain monoamine contents were only minimally influenced by L-or D-Asp administration. We conclude that D-Asp may act as an anorexigenic factor in the diencephalon.
AB - In the present study, we determined the effects of oral administration of L-and D-aspartate (L-Asp and D-Asp) on food intake over a period of 2 h after the administration, as well as its effects on the concentration of L-and D-Asp in the brain and plasma. Chicks were orally administered different levels (0, 3.75, 7.5 and 15 mmol/kg body weight) of L-Asp (Experiment 1) and D-Asp (Experiment 2). Administration of several doses of L-Asp linearly increased the concentration of L-Asp, but not of D-Asp, in plasma. Oral L-Asp somewhat modified the levels of L-and D-Asp levels in the telencephalon, but not in the diencephalon. However, food intake was not significantly changed with doses of L-Asp. On the other hand, D-Asp strongly and dose-dependently inhibited food intake over a period of 2 h after the administration. Oral D-Asp clearly increased D-Asp levels in the plasma and diencephalon, but no significant changes in L-Asp were detected. Brain monoamine contents were only minimally influenced by L-or D-Asp administration. We conclude that D-Asp may act as an anorexigenic factor in the diencephalon.
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U2 - 10.2141/jpsa.0120116
DO - 10.2141/jpsa.0120116
M3 - Article
AN - SCOPUS:84876777455
VL - 50
SP - 165
EP - 171
JO - Journal of Poultry Science
JF - Journal of Poultry Science
SN - 1346-7395
IS - 2
ER -