Oral administration of D-aspartate, but not of L-aspartate, reduces food intake in chicks

Edi Erwan, Shozo Tomonaga, Taketo Ohmori, Yuta Mutaguchi, Toshihisa Ohshima, Mao Nagasawa, Shinobu Yasuo, Yoshinaga Tamura, Mitsuhiro Furuse

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In the present study, we determined the effects of oral administration of L-and D-aspartate (L-Asp and D-Asp) on food intake over a period of 2 h after the administration, as well as its effects on the concentration of L-and D-Asp in the brain and plasma. Chicks were orally administered different levels (0, 3.75, 7.5 and 15 mmol/kg body weight) of L-Asp (Experiment 1) and D-Asp (Experiment 2). Administration of several doses of L-Asp linearly increased the concentration of L-Asp, but not of D-Asp, in plasma. Oral L-Asp somewhat modified the levels of L-and D-Asp levels in the telencephalon, but not in the diencephalon. However, food intake was not significantly changed with doses of L-Asp. On the other hand, D-Asp strongly and dose-dependently inhibited food intake over a period of 2 h after the administration. Oral D-Asp clearly increased D-Asp levels in the plasma and diencephalon, but no significant changes in L-Asp were detected. Brain monoamine contents were only minimally influenced by L-or D-Asp administration. We conclude that D-Asp may act as an anorexigenic factor in the diencephalon.

Original languageEnglish
Pages (from-to)165-171
Number of pages7
JournalJournal of Poultry Science
Volume50
Issue number2
DOIs
Publication statusPublished - May 1 2013

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aspartic acid
oral administration
food intake
chicks
mouth
dosage
brain
monoamines
body weight

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology

Cite this

Oral administration of D-aspartate, but not of L-aspartate, reduces food intake in chicks. / Erwan, Edi; Tomonaga, Shozo; Ohmori, Taketo; Mutaguchi, Yuta; Ohshima, Toshihisa; Nagasawa, Mao; Yasuo, Shinobu; Tamura, Yoshinaga; Furuse, Mitsuhiro.

In: Journal of Poultry Science, Vol. 50, No. 2, 01.05.2013, p. 165-171.

Research output: Contribution to journalArticle

Erwan, E, Tomonaga, S, Ohmori, T, Mutaguchi, Y, Ohshima, T, Nagasawa, M, Yasuo, S, Tamura, Y & Furuse, M 2013, 'Oral administration of D-aspartate, but not of L-aspartate, reduces food intake in chicks', Journal of Poultry Science, vol. 50, no. 2, pp. 165-171. https://doi.org/10.2141/jpsa.0120116
Erwan E, Tomonaga S, Ohmori T, Mutaguchi Y, Ohshima T, Nagasawa M et al. Oral administration of D-aspartate, but not of L-aspartate, reduces food intake in chicks. Journal of Poultry Science. 2013 May 1;50(2):165-171. https://doi.org/10.2141/jpsa.0120116
Erwan, Edi ; Tomonaga, Shozo ; Ohmori, Taketo ; Mutaguchi, Yuta ; Ohshima, Toshihisa ; Nagasawa, Mao ; Yasuo, Shinobu ; Tamura, Yoshinaga ; Furuse, Mitsuhiro. / Oral administration of D-aspartate, but not of L-aspartate, reduces food intake in chicks. In: Journal of Poultry Science. 2013 ; Vol. 50, No. 2. pp. 165-171.
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