Oral administration of Excitin-1 (β-alanyl-Lleucine) alters behavior and brain monoamine and amino acid concentrations in rats

Yousuke Tsuneyoshi, Momoka Sato, Shozo Tomonaga, Haruka Yamane, Koji Morishita, D. Michael Denbow, Mitsuhiro Furuse

Research output: Contribution to journalArticle

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Abstract

We previously demonstrated that β-alanyl-branched chain amino acids have excitatory effects. Therefore, we named β-alanyl-L-leucine, β-alanyl-L-isoleucine and β-alanyl-L-valine as Excitin-1, -2, and -3 , respectively. Since there is little known about the effects of Excitins, we clarified whether oral administration of Excitin-1 affects behavior in rats, alters the monoamine and amino acid levels in the central nervous system, whether Excitin-1 is incorporated into the brain, and how long it remains in the blood. Excitin-1 increased motor behavior, increasing the distance of path and number of rearings in the open field. Excitin-1 influenced some monoamine and amino acid levels in the cerebral cortex and hypothalamus. Following oral administration, Excitin-1 was detected in the cerebral cortex, hypothalamus, hippocampus and olfactory bulb. In the plasma, Excitin-1 and its metabolites β-alanine and L-leucine were recorded. The present study demonstrated that Excitin-1 was incorporated in the brain and promoted behavioral changes in rats.

Original languageEnglish
Pages (from-to)175-182
Number of pages8
JournalNutritional Neuroscience
Volume12
Issue number4
DOIs
Publication statusPublished - Aug 1 2009

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Leucine
Cerebral Cortex
Hypothalamus
Oral Administration
Amino Acids
Branched Chain Amino Acids
Isoleucine
Olfactory Bulb
Brain
Valine
Alanine
Hippocampus
Central Nervous System

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Neuroscience(all)
  • Nutrition and Dietetics

Cite this

Oral administration of Excitin-1 (β-alanyl-Lleucine) alters behavior and brain monoamine and amino acid concentrations in rats. / Tsuneyoshi, Yousuke; Sato, Momoka; Tomonaga, Shozo; Yamane, Haruka; Morishita, Koji; Denbow, D. Michael; Furuse, Mitsuhiro.

In: Nutritional Neuroscience, Vol. 12, No. 4, 01.08.2009, p. 175-182.

Research output: Contribution to journalArticle

Tsuneyoshi, Yousuke ; Sato, Momoka ; Tomonaga, Shozo ; Yamane, Haruka ; Morishita, Koji ; Denbow, D. Michael ; Furuse, Mitsuhiro. / Oral administration of Excitin-1 (β-alanyl-Lleucine) alters behavior and brain monoamine and amino acid concentrations in rats. In: Nutritional Neuroscience. 2009 ; Vol. 12, No. 4. pp. 175-182.
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