Oral administration of heat-killed Lactobacillus plantarum L-137 enhances protection against influenza virus infection by stimulation of type I interferon production in mice

Naoyoshi Maeda, Risa Nakamura, Yoshitaka Hirose, Shinji Murosaki, Yoshihiro Yamamoto, Tetsuo Kase, Yasunobu Yoshikai

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    84 Citations (Scopus)

    Abstract

    We have previously reported that heat-killed Lactobacillus plantarum L-137 (HK-LP) stimulates macrophage/dendritic cells to produce T helper (Th) 1-related cytokines in vitro and in vivo in mice. We here examined the effect of oral administration of HK-LP on protection against influenza virus infection in mice. C57BL/6 mice were orally given HK-LP from day - 7 to 7 and intranasally infected with influenza virus A/FM/1/47 (H1N1, a mouse-adapted strain) at 100 pfu on day 0. The survival time was significantly prolonged in mice treated with HK-LP than that in mice treated with PBS as controls. The viral titers in the lung were significantly lower in mice treated with HK-LP than controls at the early stage after influenza virus infection. An appreciable level of interferon (IFN)-β was detected in the serum of mice treated with HK-LP, while no IFN-β was detected in controls after influenza infection. Our results suggest that HK-LP, a potent IFN-β inducer, is useful for prevention against influenza infection.

    Original languageEnglish
    Pages (from-to)1122-1125
    Number of pages4
    JournalInternational Immunopharmacology
    Volume9
    Issue number9
    DOIs
    Publication statusPublished - Aug 1 2009

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology
    • Pharmacology

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