Hot water extract of Chlorella vulgaris (CVE) is a biological response modifier (BRM) which enhances resistance to Listeria monocytogenes through augmentation of helper T cell type 1 (Th1) responses producing gamma-interferon (γIFN). We show here that oral administration of CVE in mice suppressed the production of immunoglobulin (Ig)E against casein antigen accompanied by increased γIFN and IL-12 mRNA expression. Oral administration of CVE enhanced Th1 response to casein in the spleen of casein immunized mice. CVE may be useful for prevention of allergic diseases with a predominant Th2 response. Copyright (C) 1999 International Society for Immunopharmacology.
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