Oral administration of hot water extracts of Chlorella vulgaris reduces IgE production against milk casein in mice

T. Hasegawa, K. Ito, S. Ueno, S. Kumamoto, Y. Ando, A. Yamada, K. Nomoto, Y. Yasunobu

    Research output: Contribution to journalArticle

    46 Citations (Scopus)

    Abstract

    Hot water extract of Chlorella vulgaris (CVE) is a biological response modifier (BRM) which enhances resistance to Listeria monocytogenes through augmentation of helper T cell type 1 (Th1) responses producing gamma-interferon (γIFN). We show here that oral administration of CVE in mice suppressed the production of immunoglobulin (Ig)E against casein antigen accompanied by increased γIFN and IL-12 mRNA expression. Oral administration of CVE enhanced Th1 response to casein in the spleen of casein immunized mice. CVE may be useful for prevention of allergic diseases with a predominant Th2 response. Copyright (C) 1999 International Society for Immunopharmacology.

    Original languageEnglish
    Pages (from-to)311-323
    Number of pages13
    JournalInternational Journal of Immunopharmacology
    Volume21
    Issue number5
    DOIs
    Publication statusPublished - May 1 1999

    All Science Journal Classification (ASJC) codes

    • Immunology
    • Pharmacology

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