TY - JOUR
T1 - Oral flora composition and its connection to oral health
AU - Yamashita, Yoshihisa
AU - Takeshita, Toru
N1 - Funding Information:
This study was supported in part by The Uehara Memorial Foundation （Y. Y.）, Grants－in Aid for Young Scientists 23792517（T. T.）from the Ministry of Education, Culture, Sports, Science and Technology （MEXT）of Japan and a grant of“Strategic Research Base Development”Program for Private Universities from MEXT of Japan, 2010―2014（S1001024）.
PY - 2011
Y1 - 2011
N2 - More than 700 species of commensal bacteria inhabit the human oral cavity, of which many have been of keen interest due to their pathogenicity in oral diseases (e.g., dental caries and periodontal diseases); however, the interactions between the pathogens and the remaining commensal bacteria are not well known, thus preventing us from understanding the genuine etiologies of oral diseases. To overcome this challenge, it is essential to comprehensively identify the species compositions of individual oral flora in order to associate them with various conditions of oral health and understand the virulence derived from the oral flora community. In this review, we refer to modern molecular genetic technologies, such as terminal restriction fragment length polymorphism, DNA microarray and pyrosequencing analyses using bioinformatics. We also discuss their potential to further our comprehension of the complexities of floral composition.
AB - More than 700 species of commensal bacteria inhabit the human oral cavity, of which many have been of keen interest due to their pathogenicity in oral diseases (e.g., dental caries and periodontal diseases); however, the interactions between the pathogens and the remaining commensal bacteria are not well known, thus preventing us from understanding the genuine etiologies of oral diseases. To overcome this challenge, it is essential to comprehensively identify the species compositions of individual oral flora in order to associate them with various conditions of oral health and understand the virulence derived from the oral flora community. In this review, we refer to modern molecular genetic technologies, such as terminal restriction fragment length polymorphism, DNA microarray and pyrosequencing analyses using bioinformatics. We also discuss their potential to further our comprehension of the complexities of floral composition.
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U2 - 10.2330/joralbiosci.53.206
DO - 10.2330/joralbiosci.53.206
M3 - Review article
AN - SCOPUS:80052703585
SN - 1349-0079
VL - 53
SP - 206
EP - 212
JO - Journal of Oral Biosciences
JF - Journal of Oral Biosciences
IS - 3
ER -
