Oral 'hydrogen water' induces neuroprotective ghrelin secretion in mice

Akio Matsumoto, Megumi Yamafuji, Tomoko Tachibana, Yusaku Nakabeppu, Mami Noda, Haruaki Nakaya

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The therapeutic potential of molecular hydrogen (H 2) is emerging in a number of human diseases and in their animal models, including in particular Parkinson's disease (PD). H2 supplementation of drinking water has been shown to exert disease-modifying effects in PD patients and neuroprotective effects in experimental PD model mice. However, H2 supplementation does not result in detectable changes in striatal H 2 levels, indicating an indirect effect. Here we show that H2 supplementation increases gastric expression of mRNA encoding ghrelin, a growth hormone secretagogue, and ghrelin secretion, which are antagonized by the β 1-adrenoceptor blocker, atenolol. Strikingly, the neuroprotective effect of H 2 water was abolished by either administration of the ghrelin receptor-antagonist, D-Lys 3 GHRP-6, or atenolol. Thus, the neuroprotective effect of H2 in PD is mediated by enhanced production of ghrelin. Our findings point to potential, novel strategies for ameliorating pathophysiology in which a protective effect of H2 supplementation has been demonstrated.

Original languageEnglish
Article number3273
JournalScientific reports
Volume3
DOIs
Publication statusPublished - Nov 29 2013

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Ghrelin
Neuroprotective Agents
Parkinson Disease
Hydrogen
Atenolol
Water
Ghrelin Receptor
Corpus Striatum
Parkinsonian Disorders
Drinking Water
Adrenergic Receptors
Growth Hormone
Stomach
Animal Models
Messenger RNA
Therapeutics

All Science Journal Classification (ASJC) codes

  • General

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Oral 'hydrogen water' induces neuroprotective ghrelin secretion in mice. / Matsumoto, Akio; Yamafuji, Megumi; Tachibana, Tomoko; Nakabeppu, Yusaku; Noda, Mami; Nakaya, Haruaki.

In: Scientific reports, Vol. 3, 3273, 29.11.2013.

Research output: Contribution to journalArticle

Matsumoto, Akio ; Yamafuji, Megumi ; Tachibana, Tomoko ; Nakabeppu, Yusaku ; Noda, Mami ; Nakaya, Haruaki. / Oral 'hydrogen water' induces neuroprotective ghrelin secretion in mice. In: Scientific reports. 2013 ; Vol. 3.
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