TY - JOUR
T1 - Oral 'hydrogen water' induces neuroprotective ghrelin secretion in mice
AU - Matsumoto, Akio
AU - Yamafuji, Megumi
AU - Tachibana, Tomoko
AU - Nakabeppu, Yusaku
AU - Noda, Mami
AU - Nakaya, Haruaki
N1 - Funding Information:
The authors are grateful to Dr. Douglas T. Hess (Case Western Reserve Univ.) for valuable advice and critical reading of the manuscript, and Dr. Yoshinori Tanaka (Corporate Engineering Division, Appliances Company, Panasonic Corporation, Japan) for help with hydrogen measurement. The authors also acknowledge the technical support of Mr. Yuichiro Kojima (Kyushu Univ.). This work was partly performed in the Cooperative Research Project Program of the Medical Institute of Bioregulation, Kyushu University. This work is supported in part by Grant-in-Aid for Scientific Research on Innovative Areas (MEXT 20117008 to A.M.), Grant-in-Aid for Exploratory Research (JSPS 24659111 to A.M.), Grant-in-Aid for Scientific Research (B) (JSPS 23390053 to H.N.), Grant-in-Aid for Scientific Research (S) (JSPS 22221004 to Y.N.), Grant-in-Aid for Scientific Research (C) (JSPS 22590084 to M.N.) and Academic Challenge in Robert T. Huang Entrepreneurship of Kyushu University (to M.Y.).
PY - 2013
Y1 - 2013
N2 - The therapeutic potential of molecular hydrogen (H 2) is emerging in a number of human diseases and in their animal models, including in particular Parkinson's disease (PD). H2 supplementation of drinking water has been shown to exert disease-modifying effects in PD patients and neuroprotective effects in experimental PD model mice. However, H2 supplementation does not result in detectable changes in striatal H 2 levels, indicating an indirect effect. Here we show that H2 supplementation increases gastric expression of mRNA encoding ghrelin, a growth hormone secretagogue, and ghrelin secretion, which are antagonized by the β 1-adrenoceptor blocker, atenolol. Strikingly, the neuroprotective effect of H 2 water was abolished by either administration of the ghrelin receptor-antagonist, D-Lys 3 GHRP-6, or atenolol. Thus, the neuroprotective effect of H2 in PD is mediated by enhanced production of ghrelin. Our findings point to potential, novel strategies for ameliorating pathophysiology in which a protective effect of H2 supplementation has been demonstrated.
AB - The therapeutic potential of molecular hydrogen (H 2) is emerging in a number of human diseases and in their animal models, including in particular Parkinson's disease (PD). H2 supplementation of drinking water has been shown to exert disease-modifying effects in PD patients and neuroprotective effects in experimental PD model mice. However, H2 supplementation does not result in detectable changes in striatal H 2 levels, indicating an indirect effect. Here we show that H2 supplementation increases gastric expression of mRNA encoding ghrelin, a growth hormone secretagogue, and ghrelin secretion, which are antagonized by the β 1-adrenoceptor blocker, atenolol. Strikingly, the neuroprotective effect of H 2 water was abolished by either administration of the ghrelin receptor-antagonist, D-Lys 3 GHRP-6, or atenolol. Thus, the neuroprotective effect of H2 in PD is mediated by enhanced production of ghrelin. Our findings point to potential, novel strategies for ameliorating pathophysiology in which a protective effect of H2 supplementation has been demonstrated.
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U2 - 10.1038/srep03273
DO - 10.1038/srep03273
M3 - Article
C2 - 24253616
AN - SCOPUS:84888250631
VL - 3
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
M1 - 3273
ER -
