Oral intake of heat-killed lactobacillus plantarum L-137 decreases the incidence of upper respiratory tract infection in healthy subjects with high levels of psychological stress

Yoshitaka Hirose, Yoshihiro Yamamoto, Yasunobu Yoshikai, Shinji Murosaki

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    The immunomodulatory effects of live or non-viable lactic acid bacteria have been extensively investigated. We reported that oral intake of heat-killed Lactobacillus plantarum L-137 (HK L-137) augmented innate and acquired immunity in mice and human subjects. To examine the effects of HK L-137 intake on upper respiratory tract infection (URTI) symptoms and immune functions in human subjects, a randomised, double-blind, placebo-controlled, parallel study was conducted in subjects with high psychological stress levels. A total of seventy-eight healthy subjects (thirty-three men and forty-five women; mean age 50·6 years) with scores of >41 on eighteen-item subscales of psychological distress in the Brief Job Stress Questionnaire were randomly assigned to receive a tablet containing HK L-137 (10 mg) or a placebo tablet daily for 12 weeks. The URTI symptoms were rated once daily on the validated twenty-one-item Wisconsin Upper Respiratory Symptom Survey-21. Immune functions, such as concanavalin A-induced proliferation and percentages of interferon (IFN)-λ- and IL-4-producing CD4 T cells of peripheral blood mononuclear cells (PBMC), and serum IFN-β concentrations were measured every 4 weeks. URTI incidence was significantly lower in the HK L-137 group than in the control group. URTI incidence, duration and severity, and duration of medication showed significant negative correlations with duration of HK L-137 intake. The percentage change from baseline of concanavalin A-induced proliferation of PBMC was significantly greater in the HK L-137 group than in the control group. These findings suggest that daily HK L-137 intake can decrease URTI incidence in healthy subjects, possibly through augmentation of immune functions.

    Original languageEnglish
    Article numbere39
    Pages (from-to)1-8
    Number of pages8
    JournalJournal of Nutritional Science
    Volume2
    DOIs
    Publication statusPublished - Jan 1 2013

    Fingerprint

    1-phenyl-6,7-dihydroxy-isochroman
    Lactobacillus plantarum
    angle of incidence
    Psychological Stress
    Respiratory Tract Infections
    respiratory tract diseases
    mouth
    Healthy Volunteers
    Hot Temperature
    heat
    Incidence
    signs and symptoms (animals and humans)
    interferons
    concanavalin A
    Concanavalin A
    mononuclear leukocytes
    Interferons
    Tablets
    placebos
    duration

    All Science Journal Classification (ASJC) codes

    • Food Science
    • Endocrinology, Diabetes and Metabolism

    Cite this

    Oral intake of heat-killed lactobacillus plantarum L-137 decreases the incidence of upper respiratory tract infection in healthy subjects with high levels of psychological stress. / Hirose, Yoshitaka; Yamamoto, Yoshihiro; Yoshikai, Yasunobu; Murosaki, Shinji.

    In: Journal of Nutritional Science, Vol. 2, e39, 01.01.2013, p. 1-8.

    Research output: Contribution to journalArticle

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