TY - JOUR
T1 - Oral involvement in chronic graft-versus-host disease after allogeneic bone marrow transplantation
AU - Nakamura, Seiji
AU - Hiroki, Akiko
AU - Shinohara, Masanori
AU - Gondo, Hisashi
AU - Ohyama, Yukiko
AU - Mouri, Takefumi
AU - Sasaki, Masanori
AU - Shirasuna, Kanemitsu
AU - Harada, Mine
AU - Niho, Yoshiyuki
PY - 1996/1/1
Y1 - 1996/1/1
N2 - We examined 37 patients who had undergone an allogeneic bone marrow transplantation and compared their oral findings to their systemic involvement with chronic graft-versus-host disease. Among the clinical signs and symptoms in their oral region, only the presence of oral lichenoid lesions had a statistically significant relationship to the diagnosis of chronic graft-versus-host disease. The histologic findings in the labial salivary glands and buccal mucosa closely reflected the status of chronic graft-versus-host disease. Statistically, the presence of diffuse and periductal lymphocytic infiltration in labial salivary glands, subepithelial lymphocytic infiltration and epithelial changes in buccal mucosa also showed a significant relationship to the diagnosis of chronic graft-versus-host disease. The present study suggests that a systematic oral examination, especially pathologic examination of the labial salivary glands and buccal mucosa, is useful in evaluating the status of chronic graft-versus-host disease.
AB - We examined 37 patients who had undergone an allogeneic bone marrow transplantation and compared their oral findings to their systemic involvement with chronic graft-versus-host disease. Among the clinical signs and symptoms in their oral region, only the presence of oral lichenoid lesions had a statistically significant relationship to the diagnosis of chronic graft-versus-host disease. The histologic findings in the labial salivary glands and buccal mucosa closely reflected the status of chronic graft-versus-host disease. Statistically, the presence of diffuse and periductal lymphocytic infiltration in labial salivary glands, subepithelial lymphocytic infiltration and epithelial changes in buccal mucosa also showed a significant relationship to the diagnosis of chronic graft-versus-host disease. The present study suggests that a systematic oral examination, especially pathologic examination of the labial salivary glands and buccal mucosa, is useful in evaluating the status of chronic graft-versus-host disease.
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U2 - 10.1016/S1079-2104(96)80203-4
DO - 10.1016/S1079-2104(96)80203-4
M3 - Article
C2 - 8936521
AN - SCOPUS:0030279442
SN - 2212-4403
VL - 82
SP - 556
EP - 563
JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
IS - 5
ER -