Oral involvement in chronic graft-versus-host disease after allogeneic bone marrow transplantation

Seiji Nakamura, Akiko Hiroki, Masanori Shinohara, Hisashi Gondo, Yukiko Ohyama, Takefumi Mouri, Masanori Sasaki, Kanemitsu Shirasuna, Mine Harada, Yoshiyuki Niho

Research output: Contribution to journalArticlepeer-review

60 Citations (Scopus)

Abstract

We examined 37 patients who had undergone an allogeneic bone marrow transplantation and compared their oral findings to their systemic involvement with chronic graft-versus-host disease. Among the clinical signs and symptoms in their oral region, only the presence of oral lichenoid lesions had a statistically significant relationship to the diagnosis of chronic graft-versus-host disease. The histologic findings in the labial salivary glands and buccal mucosa closely reflected the status of chronic graft-versus-host disease. Statistically, the presence of diffuse and periductal lymphocytic infiltration in labial salivary glands, subepithelial lymphocytic infiltration and epithelial changes in buccal mucosa also showed a significant relationship to the diagnosis of chronic graft-versus-host disease. The present study suggests that a systematic oral examination, especially pathologic examination of the labial salivary glands and buccal mucosa, is useful in evaluating the status of chronic graft-versus-host disease.

Original languageEnglish
Pages (from-to)556-563
Number of pages8
JournalOral surgery, oral medicine, oral pathology, oral radiology, and endodontics
Volume82
Issue number5
DOIs
Publication statusPublished - Jan 1 1996

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology
  • Dentistry(all)

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