Oral involvement in chronic graft-versus-host disease after allogeneic bone marrow transplantation

Seiji Nakamura, Akiko Hiroki, Masanori Shinohara, Hisashi Gondo, Yukiko Ohyama, Takefumi Mouri, Masanori Sasaki, Kanemitsu Shirasuna, Mine Harada, Yoshiyuki Niho

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Abstract

We examined 37 patients who had undergone an allogeneic bone marrow transplantation and compared their oral findings to their systemic involvement with chronic graft-versus-host disease. Among the clinical signs and symptoms in their oral region, only the presence of oral lichenoid lesions had a statistically significant relationship to the diagnosis of chronic graft-versus-host disease. The histologic findings in the labial salivary glands and buccal mucosa closely reflected the status of chronic graft-versus-host disease. Statistically, the presence of diffuse and periductal lymphocytic infiltration in labial salivary glands, subepithelial lymphocytic infiltration and epithelial changes in buccal mucosa also showed a significant relationship to the diagnosis of chronic graft-versus-host disease. The present study suggests that a systematic oral examination, especially pathologic examination of the labial salivary glands and buccal mucosa, is useful in evaluating the status of chronic graft-versus-host disease.

Original languageEnglish
Pages (from-to)556-563
Number of pages8
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Volume82
Issue number5
DOIs
Publication statusPublished - Jan 1 1996

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Homologous Transplantation
Graft vs Host Disease
Bone Marrow Transplantation
Mouth Mucosa
Lip
Salivary Glands
Oral Diagnosis
Signs and Symptoms

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology
  • Dentistry(all)

Cite this

Oral involvement in chronic graft-versus-host disease after allogeneic bone marrow transplantation. / Nakamura, Seiji; Hiroki, Akiko; Shinohara, Masanori; Gondo, Hisashi; Ohyama, Yukiko; Mouri, Takefumi; Sasaki, Masanori; Shirasuna, Kanemitsu; Harada, Mine; Niho, Yoshiyuki.

In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, Vol. 82, No. 5, 01.01.1996, p. 556-563.

Research output: Contribution to journalArticle

Nakamura, Seiji ; Hiroki, Akiko ; Shinohara, Masanori ; Gondo, Hisashi ; Ohyama, Yukiko ; Mouri, Takefumi ; Sasaki, Masanori ; Shirasuna, Kanemitsu ; Harada, Mine ; Niho, Yoshiyuki. / Oral involvement in chronic graft-versus-host disease after allogeneic bone marrow transplantation. In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics. 1996 ; Vol. 82, No. 5. pp. 556-563.
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AU - Mouri, Takefumi

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