Oral squamous cell carcinoma cells modulate osteoclast function by RANKL-dependent and -independent mechanisms

Takeyuki Tada, Masashi Shin, Hidefumi Fukushima, Koji Okabe, Satoru Ozeki, Masato Okamoto, Eijiro Jimi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Oral squamous cell carcinoma (SCC) cells frequently invade mandibular bone, and bone invasion is a common clinical problem. Recent studies have revealed that bone resorption by osteoclasts is an important step in the progress of bone invasion by oral SCCs. We previously reported that oral SCC cells induce osteoclastogenesis by suppressing osteoprotegerin (OPG) in host cells. In the present study, we examined the effects of oral SCCs on osteoclast function. Both BHY cells, a human oral SCC cell line, and its conditioned medium (BHY-CM) stimulated osteoclast survival by suppressing Bim, a pro-apoptotic protein, depending on extracellular signal-regulated kinase (ERK) and multinucleation. Adding BHY cells but not BHY-CM induced pit-forming activity by osteoclasts and adding OPG abrogated the activity. Thus, oral SCC cells regulate not only osteoclastogenesis but also its function.

Original languageEnglish
Pages (from-to)126-131
Number of pages6
JournalCancer Letters
Volume274
Issue number1
DOIs
Publication statusPublished - Feb 8 2009
Externally publishedYes

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Osteoclasts
Squamous Cell Carcinoma
Osteoprotegerin
Osteogenesis
Bone and Bones
Apoptosis Regulatory Proteins
Extracellular Signal-Regulated MAP Kinases
Bone Resorption
Conditioned Culture Medium
Cell Line

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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Oral squamous cell carcinoma cells modulate osteoclast function by RANKL-dependent and -independent mechanisms. / Tada, Takeyuki; Shin, Masashi; Fukushima, Hidefumi; Okabe, Koji; Ozeki, Satoru; Okamoto, Masato; Jimi, Eijiro.

In: Cancer Letters, Vol. 274, No. 1, 08.02.2009, p. 126-131.

Research output: Contribution to journalArticle

Tada, Takeyuki ; Shin, Masashi ; Fukushima, Hidefumi ; Okabe, Koji ; Ozeki, Satoru ; Okamoto, Masato ; Jimi, Eijiro. / Oral squamous cell carcinoma cells modulate osteoclast function by RANKL-dependent and -independent mechanisms. In: Cancer Letters. 2009 ; Vol. 274, No. 1. pp. 126-131.
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