Orally administered whole egg demonstrates antidepressant-like effects in the forced swimming test on rats

Mao Nagasawa, Tsuyoshi Otsuka, Yumi Ogino, Junki Yoshida, Shozo Tomonaga, Shinobu Yasuo, Mitsuhiro Furuse

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective Several studies have reported that vegetarian diets are associated with a higher prevalence of major depression. Therefore, we hypothesised that the consumption of animal products, especially eggs, may have positive effects on mental health, especially on major depression, because a previous study reported that egg consumption produces numerous beneficial effects in humans. The purpose of the present study was to evaluate the effects of chronic whole-egg treatment on depression-like behaviours in Wistar rats, a control strain, and Wistar Kyoto rats, an animal model of depression. Methods In both the rats, either whole-egg solution (5 ml/kg) or distilled water (5 ml/kg) was orally administrated for 35 days. During these periods, the open-field test (OFT) was conducted on the 21st day, and a forced swimming test (FST) was enforced on the 27th and 28th days. On the 36th day, the plasma and brain were collected. Results Chronic whole-egg treatment did not affect line crossing in the OFT, whereas it reduced the total duration of immobility in the FST on both strains. Furthermore, interestingly, the results indicated the possibility that whole-egg treatment elevated the incorporation of tryptophan into the brain, and the tryptophan concentration in the prefrontal cortex was actually increased by the treatment. Conclusion This study demonstrated that whole-egg treatment exerts an antidepressant-like effect in the FST. It is suggested that whole egg may be an excellent food for preventing and alleviating the conditions of major depression.

Original languageEnglish
Pages (from-to)209-217
Number of pages9
JournalActa Neuropsychiatrica
Volume26
Issue number4
DOIs
Publication statusPublished - Jan 1 2014

Fingerprint

Antidepressive Agents
Ovum
Depression
Tryptophan
Vegetarian Diet
Therapeutics
Inbred WKY Rats
Brain
Prefrontal Cortex
Eggs
Wistar Rats
Mental Health
Animal Models
Food
Water

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Orally administered whole egg demonstrates antidepressant-like effects in the forced swimming test on rats. / Nagasawa, Mao; Otsuka, Tsuyoshi; Ogino, Yumi; Yoshida, Junki; Tomonaga, Shozo; Yasuo, Shinobu; Furuse, Mitsuhiro.

In: Acta Neuropsychiatrica, Vol. 26, No. 4, 01.01.2014, p. 209-217.

Research output: Contribution to journalArticle

Nagasawa, Mao ; Otsuka, Tsuyoshi ; Ogino, Yumi ; Yoshida, Junki ; Tomonaga, Shozo ; Yasuo, Shinobu ; Furuse, Mitsuhiro. / Orally administered whole egg demonstrates antidepressant-like effects in the forced swimming test on rats. In: Acta Neuropsychiatrica. 2014 ; Vol. 26, No. 4. pp. 209-217.
@article{861fa281261d49d6813cb334f23f99bc,
title = "Orally administered whole egg demonstrates antidepressant-like effects in the forced swimming test on rats",
abstract = "Objective Several studies have reported that vegetarian diets are associated with a higher prevalence of major depression. Therefore, we hypothesised that the consumption of animal products, especially eggs, may have positive effects on mental health, especially on major depression, because a previous study reported that egg consumption produces numerous beneficial effects in humans. The purpose of the present study was to evaluate the effects of chronic whole-egg treatment on depression-like behaviours in Wistar rats, a control strain, and Wistar Kyoto rats, an animal model of depression. Methods In both the rats, either whole-egg solution (5 ml/kg) or distilled water (5 ml/kg) was orally administrated for 35 days. During these periods, the open-field test (OFT) was conducted on the 21st day, and a forced swimming test (FST) was enforced on the 27th and 28th days. On the 36th day, the plasma and brain were collected. Results Chronic whole-egg treatment did not affect line crossing in the OFT, whereas it reduced the total duration of immobility in the FST on both strains. Furthermore, interestingly, the results indicated the possibility that whole-egg treatment elevated the incorporation of tryptophan into the brain, and the tryptophan concentration in the prefrontal cortex was actually increased by the treatment. Conclusion This study demonstrated that whole-egg treatment exerts an antidepressant-like effect in the FST. It is suggested that whole egg may be an excellent food for preventing and alleviating the conditions of major depression.",
author = "Mao Nagasawa and Tsuyoshi Otsuka and Yumi Ogino and Junki Yoshida and Shozo Tomonaga and Shinobu Yasuo and Mitsuhiro Furuse",
year = "2014",
month = "1",
day = "1",
doi = "10.1017/neu.2013.56",
language = "English",
volume = "26",
pages = "209--217",
journal = "Acta Neuropsychiatrica",
issn = "0924-2708",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Orally administered whole egg demonstrates antidepressant-like effects in the forced swimming test on rats

AU - Nagasawa, Mao

AU - Otsuka, Tsuyoshi

AU - Ogino, Yumi

AU - Yoshida, Junki

AU - Tomonaga, Shozo

AU - Yasuo, Shinobu

AU - Furuse, Mitsuhiro

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Objective Several studies have reported that vegetarian diets are associated with a higher prevalence of major depression. Therefore, we hypothesised that the consumption of animal products, especially eggs, may have positive effects on mental health, especially on major depression, because a previous study reported that egg consumption produces numerous beneficial effects in humans. The purpose of the present study was to evaluate the effects of chronic whole-egg treatment on depression-like behaviours in Wistar rats, a control strain, and Wistar Kyoto rats, an animal model of depression. Methods In both the rats, either whole-egg solution (5 ml/kg) or distilled water (5 ml/kg) was orally administrated for 35 days. During these periods, the open-field test (OFT) was conducted on the 21st day, and a forced swimming test (FST) was enforced on the 27th and 28th days. On the 36th day, the plasma and brain were collected. Results Chronic whole-egg treatment did not affect line crossing in the OFT, whereas it reduced the total duration of immobility in the FST on both strains. Furthermore, interestingly, the results indicated the possibility that whole-egg treatment elevated the incorporation of tryptophan into the brain, and the tryptophan concentration in the prefrontal cortex was actually increased by the treatment. Conclusion This study demonstrated that whole-egg treatment exerts an antidepressant-like effect in the FST. It is suggested that whole egg may be an excellent food for preventing and alleviating the conditions of major depression.

AB - Objective Several studies have reported that vegetarian diets are associated with a higher prevalence of major depression. Therefore, we hypothesised that the consumption of animal products, especially eggs, may have positive effects on mental health, especially on major depression, because a previous study reported that egg consumption produces numerous beneficial effects in humans. The purpose of the present study was to evaluate the effects of chronic whole-egg treatment on depression-like behaviours in Wistar rats, a control strain, and Wistar Kyoto rats, an animal model of depression. Methods In both the rats, either whole-egg solution (5 ml/kg) or distilled water (5 ml/kg) was orally administrated for 35 days. During these periods, the open-field test (OFT) was conducted on the 21st day, and a forced swimming test (FST) was enforced on the 27th and 28th days. On the 36th day, the plasma and brain were collected. Results Chronic whole-egg treatment did not affect line crossing in the OFT, whereas it reduced the total duration of immobility in the FST on both strains. Furthermore, interestingly, the results indicated the possibility that whole-egg treatment elevated the incorporation of tryptophan into the brain, and the tryptophan concentration in the prefrontal cortex was actually increased by the treatment. Conclusion This study demonstrated that whole-egg treatment exerts an antidepressant-like effect in the FST. It is suggested that whole egg may be an excellent food for preventing and alleviating the conditions of major depression.

UR - http://www.scopus.com/inward/record.url?scp=84903846350&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903846350&partnerID=8YFLogxK

U2 - 10.1017/neu.2013.56

DO - 10.1017/neu.2013.56

M3 - Article

C2 - 25142288

AN - SCOPUS:84903846350

VL - 26

SP - 209

EP - 217

JO - Acta Neuropsychiatrica

JF - Acta Neuropsychiatrica

SN - 0924-2708

IS - 4

ER -