Orally administrated dipeptide Ser-Tyr efficiently stimulates noradrenergic turnover in the mouse brain

Takashi Ichinose, Kazuki Moriyasu, Akane Nakahata, Mitsuru Tanaka, Toshiro Matsui, Shigeki Furuya

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In this study, we examined the effect of orally administrated dipeptides containing Tyr (Y) on the metabolism of catecholamines in mouse brains. We found that among eight synthetic dipeptides whose sequences are present frequently in soy proteins, Ser-Tyr (SY), Ile-Tyr, and Tyr-Pro had the highest apparent permeability coefficients in monolayers of human intestinal epithelial Caco-2 cells. When administrated orally, SY markedly increased tyrosine content in the cerebral cortex compared to the vehicle control, Ile-Tyr, Tyr-Pro, and Y alone. The oral administration of SY more effectively increased 3-methoxy-4-hydroxyphenylethyleneglycol, the principal metabolite of noradrenaline, in the cerebral cortex and hippocampus than did Ile-Tyr, Tyr-Pro, or Y alone. Central noradrenergic turnover was also markedly stimulated by SY administration. These in vivo observations strongly suggest that SY is more potent in boosting central catecholamine transmission, particularly the noradrenergic system, than Y alone or other dipeptides that include Y.

Original languageEnglish
Pages (from-to)1542-1547
Number of pages6
JournalBioscience, Biotechnology and Biochemistry
Volume79
Issue number9
DOIs
Publication statusPublished - Jan 1 2015

Fingerprint

isoleucyl-tyrosine
tyrosyl-proline
Dipeptides
Brain
Cerebral Cortex
Catecholamines
Soybean Proteins
Caco-2 Cells
Hydraulic conductivity
Metabolites
Metabolism
Oral Administration
Tyrosine
Monolayers
Permeability
Hippocampus
Norepinephrine
Epithelial Cells

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biotechnology
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

Orally administrated dipeptide Ser-Tyr efficiently stimulates noradrenergic turnover in the mouse brain. / Ichinose, Takashi; Moriyasu, Kazuki; Nakahata, Akane; Tanaka, Mitsuru; Matsui, Toshiro; Furuya, Shigeki.

In: Bioscience, Biotechnology and Biochemistry, Vol. 79, No. 9, 01.01.2015, p. 1542-1547.

Research output: Contribution to journalArticle

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