@article{d69494681d254585a472ee7c2749fb20,
title = "Organocatalytic Direct Enantioselective Hydrophosphonylation of N-Unsubstituted Ketimines for the Synthesis of α-Aminophosphonates",
abstract = "We report an organocatalyzed direct enantioselective hydrophosphonylation of N-unsubstituted ketimines that affords N-unprotected α-tetrasubstituted α-aminophosphonates without protection/deprotection steps. The reaction is suitable for N-unsubstituted isatin-derived and trifluoromethyl ketimines, affording products in high yields with excellent enantioselectivity. Applications of the reaction and a proposed transition state model are also described.",
author = "Koki Yamada and Yuta Kondo and Akihiko Kitamura and Tetsuya Kadota and Hiroyuki Morimoto and Takashi Ohshima",
note = "Funding Information: This work was supported by a Grant-in-Aid for Transformative Research Areas (A) Digitalization-driven Transformative Organic Synthesis (Digi-TOS) (MEXT KAKENHI Grants JP21A204, JP21H05207, and JP21H05208) from MEXT, Grants-in-Aid for Scientific Research (B) (JSPS KAKENHI Grants JP17H03972 and JP21H02607 to T.O.) and (C) (JSPS KAKENHI Grants JP18K06581 and JP21K06477 to H.M.) from JSPS, and Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS) (AMED Grants JP21am0101091 and JP22ama121031) from AMED. H.M. thanks the Takeda Science Foundation, the Fugaku Trust for Medical Research, and QR Program (Qdai-jump Research Program) 02249 for financial support. Y.K. thanks JSPS for Research Fellowships for Young Scientists. Y.K. is grateful for the support from the Academic Challenge Program 2018 of Kyushu University. The computations were carried out using the computer resources offered under the category of General Projects by the Research Institute for Information Technology at Kyushu University. We thank Mr. Taisuke Matsumoto (IMCE, Kyushu University) for the assistance of X-ray crystallographic analysis. Publisher Copyright: {\textcopyright} 2023 American Chemical Society.",
year = "2023",
doi = "10.1021/acscatal.2c05953",
language = "English",
pages = "3158--3163",
journal = "ACS Catalysis",
issn = "2155-5435",
publisher = "American Chemical Society",
}