Oriented Helical Peptide Layer on the Carboxylate-Terminated Alkanethiol Immobilized on a Gold Surface

Yoshiko Miura, Shunsaku Kimura, Yukio Imanishi, Junzo Umemura

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Hydrophobic helical hexadecapeptides having an ammonium group were investigated on the formation of an oriented thin layer of the helical peptides on a gold surface. The helical peptides in an ethanol solution were incubated with self-assembled monolayers (SAMs) of carboxylate-terminated alkanethiol on a gold surface to form a helical peptide layer. The thickness of the peptide layer and the orientation of the peptide layer were investigated by the surface plasmon resonance and the FTIR reflection - absorption spectroscopy, respectively. Ion-pair interaction between an ammonium group of the peptides and a carboxylate group of SAMs facilitated the formation of a peptide layer vertically oriented to the substrate. A peptide having an ammonium group and a carboxyl group especially shows a good vertical orientation to the substrate.

Original languageEnglish
Pages (from-to)1155-1160
Number of pages6
JournalLangmuir
Volume15
Issue number4
Publication statusPublished - 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry

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