Abstract
The brain or central nervous system (CNS) utilizes a vast amount of energy to sustain its basic functions, and most of the energy in the brain is derived from glucose. Whole-body energy and glucose homeostasis in the periphery of the human body are regulated by insulin, while the brain had been considered as an “insulin-insensitive” organ, because bulk brain glucose uptake is not affected by insulin in either rodents and humans. However, recently it has become clear that the actions of insulin are more widespread in the CNS and are a critical part of normal development, food intake, and energy balance, as well as plasticity throughout adulthood. Moreover, there are substantial evidence demonstrating that brain insulin is derived from pancreas, neurons, and astrocytes. In this chapter, I reviewed recent progress in roles of insulin in the brain, expression of insulin genes, and multiple origins of the brain insulin.
| Original language | English |
|---|---|
| Title of host publication | Advances in Experimental Medicine and Biology |
| Publisher | Springer New York LLC |
| Pages | 1-11 |
| Number of pages | 11 |
| DOIs | |
| Publication status | Published - Jan 1 2019 |
Publication series
| Name | Advances in Experimental Medicine and Biology |
|---|---|
| Volume | 1128 |
| ISSN (Print) | 0065-2598 |
| ISSN (Electronic) | 2214-8019 |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Origins of brain insulin and its function. / Nakabeppu, Yusaku.
Advances in Experimental Medicine and Biology. Springer New York LLC, 2019. p. 1-11 (Advances in Experimental Medicine and Biology; Vol. 1128).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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TY - CHAP
T1 - Origins of brain insulin and its function
AU - Nakabeppu, Yusaku
PY - 2019/1/1
Y1 - 2019/1/1
N2 - The brain or central nervous system (CNS) utilizes a vast amount of energy to sustain its basic functions, and most of the energy in the brain is derived from glucose. Whole-body energy and glucose homeostasis in the periphery of the human body are regulated by insulin, while the brain had been considered as an “insulin-insensitive” organ, because bulk brain glucose uptake is not affected by insulin in either rodents and humans. However, recently it has become clear that the actions of insulin are more widespread in the CNS and are a critical part of normal development, food intake, and energy balance, as well as plasticity throughout adulthood. Moreover, there are substantial evidence demonstrating that brain insulin is derived from pancreas, neurons, and astrocytes. In this chapter, I reviewed recent progress in roles of insulin in the brain, expression of insulin genes, and multiple origins of the brain insulin.
AB - The brain or central nervous system (CNS) utilizes a vast amount of energy to sustain its basic functions, and most of the energy in the brain is derived from glucose. Whole-body energy and glucose homeostasis in the periphery of the human body are regulated by insulin, while the brain had been considered as an “insulin-insensitive” organ, because bulk brain glucose uptake is not affected by insulin in either rodents and humans. However, recently it has become clear that the actions of insulin are more widespread in the CNS and are a critical part of normal development, food intake, and energy balance, as well as plasticity throughout adulthood. Moreover, there are substantial evidence demonstrating that brain insulin is derived from pancreas, neurons, and astrocytes. In this chapter, I reviewed recent progress in roles of insulin in the brain, expression of insulin genes, and multiple origins of the brain insulin.
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U2 - 10.1007/978-981-13-3540-2_1
DO - 10.1007/978-981-13-3540-2_1
M3 - Chapter
C2 - 31062322
AN - SCOPUS:85065661647
T3 - Advances in Experimental Medicine and Biology
SP - 1
EP - 11
BT - Advances in Experimental Medicine and Biology
PB - Springer New York LLC
ER -