Orostanal, a novel abeo-sterol inducing apoptosis in leukemia cell from a marine sponge, Stelletta hiwasaensis

Tomofumi Miyamoto; Kota Kodama; Yuko Aramaki; Ryuichi Higuchi; Rob W.M. Van Soest

doi:10.1016/S0040-4039(01)01278-3

Orostanal, a novel abeo-sterol inducing apoptosis in leukemia cell from a marine sponge, Stelletta hiwasaensis

Tomofumi Miyamoto, Kota Kodama, Yuko Aramaki, Ryuichi Higuchi, Rob W.M. Van Soest

Pharmaceutical Health Care and Sciences

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

A sterol derivative, orostanal, was obtained from a marine sponge of Stelletta hiwasaensis. Spectroscopic analysis and synthetic study revealed its structure as a novel 5(6→7)abeo-sterol. Orostanal and its synthetic analog induce apoptosis in human acute promyelotic leukemia cell.

Original language	English
Pages (from-to)	6349-6351
Number of pages	3
Journal	Tetrahedron Letters
Volume	42
Issue number	36
DOIs	https://doi.org/10.1016/S0040-4039(01)01278-3
Publication status	Published - Sep 3 2001

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Orostanal, a novel abeo-sterol inducing apoptosis in leukemia cell from a marine sponge, Stelletta hiwasaensis",

abstract = "A sterol derivative, orostanal, was obtained from a marine sponge of Stelletta hiwasaensis. Spectroscopic analysis and synthetic study revealed its structure as a novel 5(6→7)abeo-sterol. Orostanal and its synthetic analog induce apoptosis in human acute promyelotic leukemia cell.",

author = "Tomofumi Miyamoto and Kota Kodama and Yuko Aramaki and Ryuichi Higuchi and {Van Soest}, {Rob W.M.}",

note = "Funding Information: This work was supported in part by a Grant-in-Aid for Scientific Research (C) (No. 12672055) from The Ministry of Education, Science, Sports and Culture, Japan.",

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T1 - Orostanal, a novel abeo-sterol inducing apoptosis in leukemia cell from a marine sponge, Stelletta hiwasaensis

AU - Miyamoto, Tomofumi

AU - Kodama, Kota

AU - Aramaki, Yuko

AU - Higuchi, Ryuichi

AU - Van Soest, Rob W.M.

N1 - Funding Information: This work was supported in part by a Grant-in-Aid for Scientific Research (C) (No. 12672055) from The Ministry of Education, Science, Sports and Culture, Japan.

PY - 2001/9/3

Y1 - 2001/9/3

N2 - A sterol derivative, orostanal, was obtained from a marine sponge of Stelletta hiwasaensis. Spectroscopic analysis and synthetic study revealed its structure as a novel 5(6→7)abeo-sterol. Orostanal and its synthetic analog induce apoptosis in human acute promyelotic leukemia cell.

AB - A sterol derivative, orostanal, was obtained from a marine sponge of Stelletta hiwasaensis. Spectroscopic analysis and synthetic study revealed its structure as a novel 5(6→7)abeo-sterol. Orostanal and its synthetic analog induce apoptosis in human acute promyelotic leukemia cell.

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

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