Orostanal, a novel abeo-sterol inducing apoptosis in leukemia cell from a marine sponge, Stelletta hiwasaensis

Tomofumi Miyamoto, Kota Kodama, Yuko Aramaki, Ryuichi Higuchi, Rob W.M. Van Soest

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

A sterol derivative, orostanal, was obtained from a marine sponge of Stelletta hiwasaensis. Spectroscopic analysis and synthetic study revealed its structure as a novel 5(6→7)abeo-sterol. Orostanal and its synthetic analog induce apoptosis in human acute promyelotic leukemia cell.

Original languageEnglish
Pages (from-to)6349-6351
Number of pages3
JournalTetrahedron Letters
Volume42
Issue number36
DOIs
Publication statusPublished - Sep 3 2001

Fingerprint

Porifera
Sterols
Leukemia
Apoptosis
Spectroscopic analysis
Derivatives

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Orostanal, a novel abeo-sterol inducing apoptosis in leukemia cell from a marine sponge, Stelletta hiwasaensis. / Miyamoto, Tomofumi; Kodama, Kota; Aramaki, Yuko; Higuchi, Ryuichi; Van Soest, Rob W.M.

In: Tetrahedron Letters, Vol. 42, No. 36, 03.09.2001, p. 6349-6351.

Research output: Contribution to journalArticle

Miyamoto, Tomofumi ; Kodama, Kota ; Aramaki, Yuko ; Higuchi, Ryuichi ; Van Soest, Rob W.M. / Orostanal, a novel abeo-sterol inducing apoptosis in leukemia cell from a marine sponge, Stelletta hiwasaensis. In: Tetrahedron Letters. 2001 ; Vol. 42, No. 36. pp. 6349-6351.
@article{dfcc3dd23ce74b30a6f42346a2e5b1a0,
title = "Orostanal, a novel abeo-sterol inducing apoptosis in leukemia cell from a marine sponge, Stelletta hiwasaensis",
abstract = "A sterol derivative, orostanal, was obtained from a marine sponge of Stelletta hiwasaensis. Spectroscopic analysis and synthetic study revealed its structure as a novel 5(6→7)abeo-sterol. Orostanal and its synthetic analog induce apoptosis in human acute promyelotic leukemia cell.",
author = "Tomofumi Miyamoto and Kota Kodama and Yuko Aramaki and Ryuichi Higuchi and {Van Soest}, {Rob W.M.}",
year = "2001",
month = "9",
day = "3",
doi = "10.1016/S0040-4039(01)01278-3",
language = "English",
volume = "42",
pages = "6349--6351",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "36",

}

TY - JOUR

T1 - Orostanal, a novel abeo-sterol inducing apoptosis in leukemia cell from a marine sponge, Stelletta hiwasaensis

AU - Miyamoto, Tomofumi

AU - Kodama, Kota

AU - Aramaki, Yuko

AU - Higuchi, Ryuichi

AU - Van Soest, Rob W.M.

PY - 2001/9/3

Y1 - 2001/9/3

N2 - A sterol derivative, orostanal, was obtained from a marine sponge of Stelletta hiwasaensis. Spectroscopic analysis and synthetic study revealed its structure as a novel 5(6→7)abeo-sterol. Orostanal and its synthetic analog induce apoptosis in human acute promyelotic leukemia cell.

AB - A sterol derivative, orostanal, was obtained from a marine sponge of Stelletta hiwasaensis. Spectroscopic analysis and synthetic study revealed its structure as a novel 5(6→7)abeo-sterol. Orostanal and its synthetic analog induce apoptosis in human acute promyelotic leukemia cell.

UR - http://www.scopus.com/inward/record.url?scp=0035801850&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035801850&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(01)01278-3

DO - 10.1016/S0040-4039(01)01278-3

M3 - Article

VL - 42

SP - 6349

EP - 6351

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 36

ER -