Orostanal, a novel abeo-sterol inducing apoptosis in leukemia cell from a marine sponge, Stelletta hiwasaensis

Tomofumi Miyamoto; Kota Kodama; Yuko Aramaki; Ryuichi Higuchi; Rob W.M. Van Soest

doi:10.1016/S0040-4039(01)01278-3

Orostanal, a novel abeo-sterol inducing apoptosis in leukemia cell from a marine sponge, Stelletta hiwasaensis

Tomofumi Miyamoto, Kota Kodama, Yuko Aramaki, Ryuichi Higuchi, Rob W.M. Van Soest

Pharmaceutical Health Care and Sciences

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37 Citations (Scopus)

Abstract

A sterol derivative, orostanal, was obtained from a marine sponge of Stelletta hiwasaensis. Spectroscopic analysis and synthetic study revealed its structure as a novel 5(6→7)abeo-sterol. Orostanal and its synthetic analog induce apoptosis in human acute promyelotic leukemia cell.

Original language	English
Pages (from-to)	6349-6351
Number of pages	3
Journal	Tetrahedron Letters
Volume	42
Issue number	36
DOIs	https://doi.org/10.1016/S0040-4039(01)01278-3
Publication status	Published - Sep 3 2001

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All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

Cite this

Miyamoto, T., Kodama, K., Aramaki, Y., Higuchi, R., & Van Soest, R. W. M. (2001). Orostanal, a novel abeo-sterol inducing apoptosis in leukemia cell from a marine sponge, Stelletta hiwasaensis. Tetrahedron Letters, 42(36), 6349-6351. https://doi.org/10.1016/S0040-4039(01)01278-3

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10.1016/S0040-4039(01)01278-3