Orostanal, a novel abeo-sterol inducing apoptosis in leukemia cell from a marine sponge, Stelletta hiwasaensis

Tomofumi Miyamoto, Kota Kodama, Yuko Aramaki, Ryuichi Higuchi, Rob W.M. Van Soest

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Abstract

A sterol derivative, orostanal, was obtained from a marine sponge of Stelletta hiwasaensis. Spectroscopic analysis and synthetic study revealed its structure as a novel 5(6→7)abeo-sterol. Orostanal and its synthetic analog induce apoptosis in human acute promyelotic leukemia cell.

Original languageEnglish
Pages (from-to)6349-6351
Number of pages3
JournalTetrahedron Letters
Volume42
Issue number36
DOIs
Publication statusPublished - Sep 3 2001

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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