TY - JOUR
T1 - Osteoclast-like multi-nucleated giant cells in uraemic tumoral calcinosis
AU - Yamada, Shunsuke
AU - Taniguchi, Masatomo
AU - Tokumoto, Masanori
AU - Tsuruya, Kazuhiko
AU - Iida, Mitsuo
N1 - Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2009/4
Y1 - 2009/4
N2 - A 46-year-old woman under 6-year haemodialysis was admitted for uncontrollable hip pain. An X-ray film revealed calcified mass around the 'left femur head', which was diagnosed as calcium deposition by percutaneous biopsy. Calcinotic tissues were removed surgically, and the resected specimen revealed tumoral calcinosis caused by low bone turnover. A complete resolution of calcinotic lesions around the 'left knee' occurred 6 months after treatment modification. Immunohistochemistry showed recruitment of multi-nucleated giant cells positive for CD68, tartrate resistant acidic phosphatase and calcitonin receptor, indicative of osteoclast-like features. We propose the involvement of osteoclast-like cells in active resorption of tumoral calcinosis.
AB - A 46-year-old woman under 6-year haemodialysis was admitted for uncontrollable hip pain. An X-ray film revealed calcified mass around the 'left femur head', which was diagnosed as calcium deposition by percutaneous biopsy. Calcinotic tissues were removed surgically, and the resected specimen revealed tumoral calcinosis caused by low bone turnover. A complete resolution of calcinotic lesions around the 'left knee' occurred 6 months after treatment modification. Immunohistochemistry showed recruitment of multi-nucleated giant cells positive for CD68, tartrate resistant acidic phosphatase and calcitonin receptor, indicative of osteoclast-like features. We propose the involvement of osteoclast-like cells in active resorption of tumoral calcinosis.
UR - http://www.scopus.com/inward/record.url?scp=77953931973&partnerID=8YFLogxK
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U2 - 10.1093/ndtplus/sfp010
DO - 10.1093/ndtplus/sfp010
M3 - Article
AN - SCOPUS:77953931973
VL - 2
SP - 155
EP - 157
JO - CKJ: Clinical Kidney Journal
JF - CKJ: Clinical Kidney Journal
SN - 2048-8505
IS - 2
ER -