Osteoclast-related markers in the hip joint fluid with subchondral insufficiency fracture of the femoral head

Yusuke Kubo, goro motomura, Satoshi Ikemura, Hiroyuki Hatanaka, Jun-Ichi Fukushi, Satoshi Hamai, Takuaki Yamamoto, Yasuharu Nakashima

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Abstract

Similar to the radiological findings in rapidly destructive arthrosis of the hip joint (RDA), subchondral insufficiency fracture of the femoral head (SIF) can result in progressive femoral head collapse of unknown etiology. We thus examined the osteoclast activity of hip joint fluid in SIF with progressive collapse in comparison with that in RDA. Twenty-nine hip joint fluid samples were obtained intraoperatively with whole femoral heads from 12 SIF patients and 17 RDA patients. SIF cases were classified into subgroups based on the presence of ≥2 mm collapse on preoperative radiographs: SIF with progressive collapse (n = 5) and SIF without progressive collapse (n = 7). The levels of tartrate-resistant acid phosphatase (TRACP)-5b, interleukin-8, vascular endothelial growth factor (VEGF), and matrix metalloproteinase (MMP)-9 were measured. The number of multinuclear giant cells at the subchondral region was histopathologically assessed using mid-coronal slice of each femoral head specimen. The median levels of all markers and the median number of multinuclear giant cells in SIF with progressive collapse were significantly higher than those in SIF without progressive collapse, while there were no significant differences in SIF with progressive collapse versus RDA. Regression analysis showed that the number of multinuclear giant cells was positively correlated with the level of TRACP-5b in joint fluid. The present study demonstrated the possible association of increased osteoclast activity with the existing condition of progressive collapse in SIF, which was quite similar to the findings in RDA, indicating that increased osteoclast activity may reflect the condition of progressive collapse in SIF as well as RDA.

Original languageEnglish
Pages (from-to)2987-2995
Number of pages9
JournalJournal of Orthopaedic Research
Volume36
Issue number11
DOIs
Publication statusPublished - Nov 1 2018

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Stress Fractures
Hip Joint
Osteoclasts
Thigh
Giant Cells
Joint Diseases
Matrix Metalloproteinase 9
Interleukin-8
Vascular Endothelial Growth Factor A
Joints
Regression Analysis
Tartrate-Resistant Acid Phosphatase

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine

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Osteoclast-related markers in the hip joint fluid with subchondral insufficiency fracture of the femoral head. / Kubo, Yusuke; motomura, goro; Ikemura, Satoshi; Hatanaka, Hiroyuki; Fukushi, Jun-Ichi; Hamai, Satoshi; Yamamoto, Takuaki; Nakashima, Yasuharu.

In: Journal of Orthopaedic Research, Vol. 36, No. 11, 01.11.2018, p. 2987-2995.

Research output: Contribution to journalArticle

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