TY - JOUR
T1 - Osteoclasts are involved in the maintenance of dormant leukemic cells
AU - Yokota, Asumi
AU - Kimura, Shinya
AU - Tanaka, Ruriko
AU - Takeuchi, Miki
AU - Yao, Hisayuki
AU - Sakai, Kazuki
AU - Nagao, Rina
AU - Kuroda, Junya
AU - Kamitsuji, Yuri
AU - Kawata, Eri
AU - Ashihara, Eishi
AU - Maekawa, Taira
N1 - Funding Information:
We gratefully thank Prof. Naoyuki Takahashi and Prof. Nobuyuki Udagawa, Matsumoto Dental University, for technical advice, and Yoko Nakagawa for her excellent technical support. This work was supported by a Grant-in-Aid for Japan Society for the Promotion of Science (JSPS) Fellows.
Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2010/6
Y1 - 2010/6
N2 - Osteoclasts (OCs) are specialized cells for the resorption of bone matrix that have also been recently reported to be involved in the mobilization of hematopoietic progenitor cells. When Ba/F3 cells expressing wild-type bcr-abl were co-cultured with osteoblasts (OBs), OCs, and bone slices, their proliferation was significantly suppressed, and the Ki-67 negative population, which is believed to be in G0 phase, was increased. The results of our in vitro experiments suggest that OCs could be involved in the maintenance of dormant leukemic cells in the bone marrow (BM) microenvironment through the release of soluble factors, one of which could be TGF-β.
AB - Osteoclasts (OCs) are specialized cells for the resorption of bone matrix that have also been recently reported to be involved in the mobilization of hematopoietic progenitor cells. When Ba/F3 cells expressing wild-type bcr-abl were co-cultured with osteoblasts (OBs), OCs, and bone slices, their proliferation was significantly suppressed, and the Ki-67 negative population, which is believed to be in G0 phase, was increased. The results of our in vitro experiments suggest that OCs could be involved in the maintenance of dormant leukemic cells in the bone marrow (BM) microenvironment through the release of soluble factors, one of which could be TGF-β.
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U2 - 10.1016/j.leukres.2009.08.034
DO - 10.1016/j.leukres.2009.08.034
M3 - Article
C2 - 19781772
AN - SCOPUS:77952095079
VL - 34
SP - 793
EP - 799
JO - Leukemia Research
JF - Leukemia Research
SN - 0145-2126
IS - 6
ER -
