Osteoclasts are involved in the maintenance of dormant leukemic cells

Asumi Yokota; Shinya Kimura; Ruriko Tanaka; Miki Takeuchi; Hisayuki Yao; Kazuki Sakai; Rina Nagao; Junya Kuroda; Yuri Kamitsuji; Eri Kawata; Eishi Ashihara; Taira Maekawa

doi:10.1016/j.leukres.2009.08.034

Osteoclasts are involved in the maintenance of dormant leukemic cells

Asumi Yokota, Shinya Kimura, Ruriko Tanaka, Miki Takeuchi, Hisayuki Yao, Kazuki Sakai, Rina Nagao, Junya Kuroda, Yuri Kamitsuji, Eri Kawata, Eishi Ashihara, Taira Maekawa

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Osteoclasts (OCs) are specialized cells for the resorption of bone matrix that have also been recently reported to be involved in the mobilization of hematopoietic progenitor cells. When Ba/F3 cells expressing wild-type bcr-abl were co-cultured with osteoblasts (OBs), OCs, and bone slices, their proliferation was significantly suppressed, and the Ki-67 negative population, which is believed to be in G₀ phase, was increased. The results of our in vitro experiments suggest that OCs could be involved in the maintenance of dormant leukemic cells in the bone marrow (BM) microenvironment through the release of soluble factors, one of which could be TGF-β.

Original language	English
Pages (from-to)	793-799
Number of pages	7
Journal	Leukemia Research
Volume	34
Issue number	6
DOIs	https://doi.org/10.1016/j.leukres.2009.08.034
Publication status	Published - Jun 1 2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

Hematology
Oncology
Cancer Research

Access to Document

10.1016/j.leukres.2009.08.034

Fingerprint Dive into the research topics of 'Osteoclasts are involved in the maintenance of dormant leukemic cells'. Together they form a unique fingerprint.

Cite this

Osteoclasts are involved in the maintenance of dormant leukemic cells. / Yokota, Asumi; Kimura, Shinya; Tanaka, Ruriko; Takeuchi, Miki; Yao, Hisayuki; Sakai, Kazuki; Nagao, Rina; Kuroda, Junya; Kamitsuji, Yuri; Kawata, Eri; Ashihara, Eishi; Maekawa, Taira.

In: Leukemia Research, Vol. 34, No. 6, 01.06.2010, p. 793-799.

Research output: Contribution to journal › Article › peer-review

@article{367fefcab0c342299c69bc2710b774ac,

title = "Osteoclasts are involved in the maintenance of dormant leukemic cells",

abstract = "Osteoclasts (OCs) are specialized cells for the resorption of bone matrix that have also been recently reported to be involved in the mobilization of hematopoietic progenitor cells. When Ba/F3 cells expressing wild-type bcr-abl were co-cultured with osteoblasts (OBs), OCs, and bone slices, their proliferation was significantly suppressed, and the Ki-67 negative population, which is believed to be in G0 phase, was increased. The results of our in vitro experiments suggest that OCs could be involved in the maintenance of dormant leukemic cells in the bone marrow (BM) microenvironment through the release of soluble factors, one of which could be TGF-β.",

author = "Asumi Yokota and Shinya Kimura and Ruriko Tanaka and Miki Takeuchi and Hisayuki Yao and Kazuki Sakai and Rina Nagao and Junya Kuroda and Yuri Kamitsuji and Eri Kawata and Eishi Ashihara and Taira Maekawa",

year = "2010",

month = jun,

day = "1",

doi = "10.1016/j.leukres.2009.08.034",

language = "English",

volume = "34",

pages = "793--799",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Limited",

number = "6",

}

TY - JOUR

T1 - Osteoclasts are involved in the maintenance of dormant leukemic cells

AU - Yokota, Asumi

AU - Kimura, Shinya

AU - Tanaka, Ruriko

AU - Takeuchi, Miki

AU - Yao, Hisayuki

AU - Sakai, Kazuki

AU - Nagao, Rina

AU - Kuroda, Junya

AU - Kamitsuji, Yuri

AU - Kawata, Eri

AU - Ashihara, Eishi

AU - Maekawa, Taira

PY - 2010/6/1

Y1 - 2010/6/1

N2 - Osteoclasts (OCs) are specialized cells for the resorption of bone matrix that have also been recently reported to be involved in the mobilization of hematopoietic progenitor cells. When Ba/F3 cells expressing wild-type bcr-abl were co-cultured with osteoblasts (OBs), OCs, and bone slices, their proliferation was significantly suppressed, and the Ki-67 negative population, which is believed to be in G0 phase, was increased. The results of our in vitro experiments suggest that OCs could be involved in the maintenance of dormant leukemic cells in the bone marrow (BM) microenvironment through the release of soluble factors, one of which could be TGF-β.

AB - Osteoclasts (OCs) are specialized cells for the resorption of bone matrix that have also been recently reported to be involved in the mobilization of hematopoietic progenitor cells. When Ba/F3 cells expressing wild-type bcr-abl were co-cultured with osteoblasts (OBs), OCs, and bone slices, their proliferation was significantly suppressed, and the Ki-67 negative population, which is believed to be in G0 phase, was increased. The results of our in vitro experiments suggest that OCs could be involved in the maintenance of dormant leukemic cells in the bone marrow (BM) microenvironment through the release of soluble factors, one of which could be TGF-β.

UR - http://www.scopus.com/inward/record.url?scp=77952095079&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952095079&partnerID=8YFLogxK

U2 - 10.1016/j.leukres.2009.08.034

DO - 10.1016/j.leukres.2009.08.034

M3 - Article

C2 - 19781772

AN - SCOPUS:77952095079

VL - 34

SP - 793

EP - 799

JO - Leukemia Research

JF - Leukemia Research

SN - 0145-2126

IS - 6

ER -