Osteoconductivity and bioresorption of an interconnecting porous carbonate apatite with enhanced mechanical strength

Nguyen Xuan Thanh Tram, Michito Maruta, Kanji Tusru, Shigeki Matsuya, Kunio Ishikawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have established a processing method to fabricate three-dimensional porous carbonate apatite (CO3Ap) with interconnected porous structure and improved mechanical strength. Briefly, porous CO3Ap materials were produced via phosphorization of porous calcite precursor in hydrothermal condition. In order to make porous calcite precursor, negative replication of modified polyurethane foam template was conducted. In this study, an in vivo behavior of that porous CO3Ap was evaluated. The interconnected porous CO3Ap material was implanted in the tibia of Japanese male rabbits and removed after a period of 6 months. Micro-computed tomography (μ-CT) scanner and histological analysis were used to characterize the bone formation response of the porous CO3Ap. The results suggest that porous CO3Ap with enhanced mechanical strength was not only osteoconductive but also bioresorbable therefore it could be used as bone substitute material.

Original languageEnglish
Title of host publicationBioceramics 27
EditorsIka Dewi Ana, Kuwat Triyana
PublisherTrans Tech Publications Ltd
Pages23-26
Number of pages4
ISBN (Print)9783035710403
DOIs
Publication statusPublished - Jan 1 2016
Event27th Symposium and Annual Meeting of the International Society for Ceramics in Medicine, 2015 - Bali, Indonesia
Duration: Oct 27 2015Oct 29 2015

Publication series

NameKey Engineering Materials
Volume696
ISSN (Print)1013-9826
ISSN (Electronic)1662-9795

Other

Other27th Symposium and Annual Meeting of the International Society for Ceramics in Medicine, 2015
CountryIndonesia
CityBali
Period10/27/1510/29/15

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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  • Cite this

    Tram, N. X. T., Maruta, M., Tusru, K., Matsuya, S., & Ishikawa, K. (2016). Osteoconductivity and bioresorption of an interconnecting porous carbonate apatite with enhanced mechanical strength. In I. D. Ana, & K. Triyana (Eds.), Bioceramics 27 (pp. 23-26). (Key Engineering Materials; Vol. 696). Trans Tech Publications Ltd. https://doi.org/10.4028/www.scientific.net/KEM.696.23