Osteoconductivity of porous titanium having young's modulus similar to bone and surface modification by OCP

Yuko Suzuki, Naoyuki Nomura, Shuji Hanada, Shinji Kamakura, Takahisa Anada, Takeshi Fuji, Yoshitomo Honda, Taisuke Masuda, Keiichi Sasaki, Shoichi Kokubun, Osamu Suzuki

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The present study was designed to investigate whether porous titanium (Ti) having Young's modulus similar to bone has osteoconductive characteristics in rat critical-sized calvarial bone defect. The effect of coating by octacalcium phosphate (OCP) was also examined. OCP is known as a precursor of initial mineral crystals of biological apatite in bones and teeth. Ti powder was prepared by plasma rotating electrode process in an Ar atmosphere. Then, porous Ti disks, 8 mm in diameter with 1 mm thick, were obtained using the particles ranging from 300 to 500 μm, by sintering at 1573 K without applied pressure. The disks had about 35 vol% in porosity and about 10 GPa in Young's modulus which corresponds to that of human cortical bone. Newly formed bone was observed so as to fill the pore up at 12 weeks, confirming the ability to conduct the ingrowths of the bone tissue. Although in vitro study showed that proliferation of mouse bone marrow stromal ST-2 cells was inhibited on the dishes coated by OCP rather than the control dish, OCP coating on porous Ti seemed to stimulate the bone formation in vivo. Taken together, it seems likely that porous Ti having Young's modulus similar to bone shows osteoconductive characteristics to conduct bone ingrowths. OCP could be a potential coating agent to assist bone regeneration on porous Ti.

Original languageEnglish
Pages (from-to)951-954
Number of pages4
JournalKey Engineering Materials
Volume330-332 II
Publication statusPublished - Jan 24 2007

Fingerprint

Titanium
Surface treatment
Bone
Phosphates
Elastic moduli
octacalcium phosphate
Phosphate coatings
Apatites
Coatings
Apatite
Powders
Minerals
Rats
Sintering
Porosity
Tissue
Plasmas
Defects
Crystals
Electrodes

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Suzuki, Y., Nomura, N., Hanada, S., Kamakura, S., Anada, T., Fuji, T., ... Suzuki, O. (2007). Osteoconductivity of porous titanium having young's modulus similar to bone and surface modification by OCP. Key Engineering Materials, 330-332 II, 951-954.

Osteoconductivity of porous titanium having young's modulus similar to bone and surface modification by OCP. / Suzuki, Yuko; Nomura, Naoyuki; Hanada, Shuji; Kamakura, Shinji; Anada, Takahisa; Fuji, Takeshi; Honda, Yoshitomo; Masuda, Taisuke; Sasaki, Keiichi; Kokubun, Shoichi; Suzuki, Osamu.

In: Key Engineering Materials, Vol. 330-332 II, 24.01.2007, p. 951-954.

Research output: Contribution to journalArticle

Suzuki, Y, Nomura, N, Hanada, S, Kamakura, S, Anada, T, Fuji, T, Honda, Y, Masuda, T, Sasaki, K, Kokubun, S & Suzuki, O 2007, 'Osteoconductivity of porous titanium having young's modulus similar to bone and surface modification by OCP', Key Engineering Materials, vol. 330-332 II, pp. 951-954.
Suzuki, Yuko ; Nomura, Naoyuki ; Hanada, Shuji ; Kamakura, Shinji ; Anada, Takahisa ; Fuji, Takeshi ; Honda, Yoshitomo ; Masuda, Taisuke ; Sasaki, Keiichi ; Kokubun, Shoichi ; Suzuki, Osamu. / Osteoconductivity of porous titanium having young's modulus similar to bone and surface modification by OCP. In: Key Engineering Materials. 2007 ; Vol. 330-332 II. pp. 951-954.
@article{21585531a9d649f5af741cddbef5062e,
title = "Osteoconductivity of porous titanium having young's modulus similar to bone and surface modification by OCP",
abstract = "The present study was designed to investigate whether porous titanium (Ti) having Young's modulus similar to bone has osteoconductive characteristics in rat critical-sized calvarial bone defect. The effect of coating by octacalcium phosphate (OCP) was also examined. OCP is known as a precursor of initial mineral crystals of biological apatite in bones and teeth. Ti powder was prepared by plasma rotating electrode process in an Ar atmosphere. Then, porous Ti disks, 8 mm in diameter with 1 mm thick, were obtained using the particles ranging from 300 to 500 μm, by sintering at 1573 K without applied pressure. The disks had about 35 vol{\%} in porosity and about 10 GPa in Young's modulus which corresponds to that of human cortical bone. Newly formed bone was observed so as to fill the pore up at 12 weeks, confirming the ability to conduct the ingrowths of the bone tissue. Although in vitro study showed that proliferation of mouse bone marrow stromal ST-2 cells was inhibited on the dishes coated by OCP rather than the control dish, OCP coating on porous Ti seemed to stimulate the bone formation in vivo. Taken together, it seems likely that porous Ti having Young's modulus similar to bone shows osteoconductive characteristics to conduct bone ingrowths. OCP could be a potential coating agent to assist bone regeneration on porous Ti.",
author = "Yuko Suzuki and Naoyuki Nomura and Shuji Hanada and Shinji Kamakura and Takahisa Anada and Takeshi Fuji and Yoshitomo Honda and Taisuke Masuda and Keiichi Sasaki and Shoichi Kokubun and Osamu Suzuki",
year = "2007",
month = "1",
day = "24",
language = "English",
volume = "330-332 II",
pages = "951--954",
journal = "Key Engineering Materials",
issn = "1013-9826",
publisher = "Trans Tech Publications",

}

TY - JOUR

T1 - Osteoconductivity of porous titanium having young's modulus similar to bone and surface modification by OCP

AU - Suzuki, Yuko

AU - Nomura, Naoyuki

AU - Hanada, Shuji

AU - Kamakura, Shinji

AU - Anada, Takahisa

AU - Fuji, Takeshi

AU - Honda, Yoshitomo

AU - Masuda, Taisuke

AU - Sasaki, Keiichi

AU - Kokubun, Shoichi

AU - Suzuki, Osamu

PY - 2007/1/24

Y1 - 2007/1/24

N2 - The present study was designed to investigate whether porous titanium (Ti) having Young's modulus similar to bone has osteoconductive characteristics in rat critical-sized calvarial bone defect. The effect of coating by octacalcium phosphate (OCP) was also examined. OCP is known as a precursor of initial mineral crystals of biological apatite in bones and teeth. Ti powder was prepared by plasma rotating electrode process in an Ar atmosphere. Then, porous Ti disks, 8 mm in diameter with 1 mm thick, were obtained using the particles ranging from 300 to 500 μm, by sintering at 1573 K without applied pressure. The disks had about 35 vol% in porosity and about 10 GPa in Young's modulus which corresponds to that of human cortical bone. Newly formed bone was observed so as to fill the pore up at 12 weeks, confirming the ability to conduct the ingrowths of the bone tissue. Although in vitro study showed that proliferation of mouse bone marrow stromal ST-2 cells was inhibited on the dishes coated by OCP rather than the control dish, OCP coating on porous Ti seemed to stimulate the bone formation in vivo. Taken together, it seems likely that porous Ti having Young's modulus similar to bone shows osteoconductive characteristics to conduct bone ingrowths. OCP could be a potential coating agent to assist bone regeneration on porous Ti.

AB - The present study was designed to investigate whether porous titanium (Ti) having Young's modulus similar to bone has osteoconductive characteristics in rat critical-sized calvarial bone defect. The effect of coating by octacalcium phosphate (OCP) was also examined. OCP is known as a precursor of initial mineral crystals of biological apatite in bones and teeth. Ti powder was prepared by plasma rotating electrode process in an Ar atmosphere. Then, porous Ti disks, 8 mm in diameter with 1 mm thick, were obtained using the particles ranging from 300 to 500 μm, by sintering at 1573 K without applied pressure. The disks had about 35 vol% in porosity and about 10 GPa in Young's modulus which corresponds to that of human cortical bone. Newly formed bone was observed so as to fill the pore up at 12 weeks, confirming the ability to conduct the ingrowths of the bone tissue. Although in vitro study showed that proliferation of mouse bone marrow stromal ST-2 cells was inhibited on the dishes coated by OCP rather than the control dish, OCP coating on porous Ti seemed to stimulate the bone formation in vivo. Taken together, it seems likely that porous Ti having Young's modulus similar to bone shows osteoconductive characteristics to conduct bone ingrowths. OCP could be a potential coating agent to assist bone regeneration on porous Ti.

UR - http://www.scopus.com/inward/record.url?scp=33846322907&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846322907&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33846322907

VL - 330-332 II

SP - 951

EP - 954

JO - Key Engineering Materials

JF - Key Engineering Materials

SN - 1013-9826

ER -