Osteogenic differentiation in dedifferentiated liposarcoma: a study of 36 cases in comparison to the cases without ossification

Kyoko Yamashita; Kenichi Kohashi; Yuichi Yamada; Takeaki Ishii; Yoshihiro Nishida; Hiroshi Urakawa; Ichiro Ito; Mitsuru Takahashi; Takeshi Inoue; Masafumi Ito; Yuuki Ohara; Yoshinao Oda; Shinya Toyokuni

doi:10.1111/his.13421

Osteogenic differentiation in dedifferentiated liposarcoma: a study of 36 cases in comparison to the cases without ossification

Kyoko Yamashita, Kenichi Kohashi, Yuichi Yamada, Takeaki Ishii, Yoshihiro Nishida, Hiroshi Urakawa, Ichiro Ito, Mitsuru Takahashi, Takeshi Inoue, Masafumi Ito, Yuuki Ohara, Yoshinao Oda, Shinya Toyokuni

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Abstract

Aims: Ossification is found occasionally in dedifferentiated liposarcoma (DDLPS). The aims of this study were to elucidate whether the formed bone tissue is usually produced by tumour cells or by reactive non-neoplastic cells, and to reveal the clinicopathological characteristics of DDLPS with ossification. Methods and results: We examined 36 cases of ossified DDLPS by comparing them to 31 cases of non-ossified DDLPS. MDM2 amplification was confirmed in osteocytes and/or osteoblastic cells in all but one ossified DDLPS cases (27 of 28) using fluorescence in-situ hybridisation, although the morphological impression of ossification appeared to be mainly metaplastic (27 of 36) or high-grade osteosarcoma-like (six of 36). The bone tissue was often formed predominantly at the periphery of the DDLPS area near the well-differentiated liposarcoma component (18 of 36), and an organised structure such as bone marrow-like differentiation was not uncommon (12 of 36). According to a modified French Fédération Nationale des Centers de Lutte Contre le Cancer (FNCLCC) grading system, ossified DDLPS tended to be lower grade than non-ossified DDLPS (mean grade: 1.88 and 2.15, respectively). Ossification in DDLPS was associated significantly with shorter local recurrence-free survival by multivariate analysis (P = 0.02347), but metaplastic-appearing ossification tended to be associated with longer overall survival (P = 0.1400). Conclusions: The bone tissue formed in DDLPS was mainly neoplastic regardless of its morphology and maturity, which highlighted the osteogenic differentiation of the tumour cells. DDLPS patients with osteogenic differentiation tended to suffer from earlier local recurrences, which did not necessarily lead to poor life outcomes.

Original language	English
Pages (from-to)	729-738
Number of pages	10
Journal	Histopathology
Volume	72
Issue number	5
DOIs	https://doi.org/10.1111/his.13421
Publication status	Published - Apr 2018

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine
Histology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/his.13421

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@article{05bcdc40557f48438ada0b0cd0b7fcf9,

title = "Osteogenic differentiation in dedifferentiated liposarcoma: a study of 36 cases in comparison to the cases without ossification",

abstract = "Aims: Ossification is found occasionally in dedifferentiated liposarcoma (DDLPS). The aims of this study were to elucidate whether the formed bone tissue is usually produced by tumour cells or by reactive non-neoplastic cells, and to reveal the clinicopathological characteristics of DDLPS with ossification. Methods and results: We examined 36 cases of ossified DDLPS by comparing them to 31 cases of non-ossified DDLPS. MDM2 amplification was confirmed in osteocytes and/or osteoblastic cells in all but one ossified DDLPS cases (27 of 28) using fluorescence in-situ hybridisation, although the morphological impression of ossification appeared to be mainly metaplastic (27 of 36) or high-grade osteosarcoma-like (six of 36). The bone tissue was often formed predominantly at the periphery of the DDLPS area near the well-differentiated liposarcoma component (18 of 36), and an organised structure such as bone marrow-like differentiation was not uncommon (12 of 36). According to a modified French F{\'e}d{\'e}ration Nationale des Centers de Lutte Contre le Cancer (FNCLCC) grading system, ossified DDLPS tended to be lower grade than non-ossified DDLPS (mean grade: 1.88 and 2.15, respectively). Ossification in DDLPS was associated significantly with shorter local recurrence-free survival by multivariate analysis (P = 0.02347), but metaplastic-appearing ossification tended to be associated with longer overall survival (P = 0.1400). Conclusions: The bone tissue formed in DDLPS was mainly neoplastic regardless of its morphology and maturity, which highlighted the osteogenic differentiation of the tumour cells. DDLPS patients with osteogenic differentiation tended to suffer from earlier local recurrences, which did not necessarily lead to poor life outcomes.",

author = "Kyoko Yamashita and Kenichi Kohashi and Yuichi Yamada and Takeaki Ishii and Yoshihiro Nishida and Hiroshi Urakawa and Ichiro Ito and Mitsuru Takahashi and Takeshi Inoue and Masafumi Ito and Yuuki Ohara and Yoshinao Oda and Shinya Toyokuni",

note = "Funding Information: Diagnostics, Aichi Cancer Center Hospital) and Dr Masafumi Ito (Department of Pathology, Nishio Municipal Hospital). This study was supported by JSPS KAKENHI Grant Number JP 16K19079 (K.Y.). This work was presented in part at the 106th Annual Meeting of the United States and Canadian Academy of Pathology in San Antonio, Texas, USA, March 2017. Funding Information: The authors would like to thank the following pathologists who kindly provided case materials: Dr Shigeo Nakamura (Department of Pathology and Laboratory Medicine, Nagoya University Hospital), Dr Yasushi Yatabe (Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital) and Dr Masafumi Ito (Department of Pathology, Nishio Municipal Hospital). This study was supported by JSPS KAKENHI Grant Number JP 16K19079 (K.Y.). This work was presented in part at the 106th Annual Meeting of the United States and Canadian Academy of Pathology in San Antonio, Texas, USA, March 2017. Publisher Copyright: {\textcopyright} 2017 John Wiley & Sons Ltd",

year = "2018",

month = apr,

doi = "10.1111/his.13421",

language = "English",

volume = "72",

pages = "729--738",

journal = "Histopathology",

issn = "0309-0167",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Osteogenic differentiation in dedifferentiated liposarcoma

T2 - a study of 36 cases in comparison to the cases without ossification

AU - Yamashita, Kyoko

AU - Kohashi, Kenichi

AU - Yamada, Yuichi

AU - Ishii, Takeaki

AU - Nishida, Yoshihiro

AU - Urakawa, Hiroshi

AU - Ito, Ichiro

AU - Takahashi, Mitsuru

AU - Inoue, Takeshi

AU - Ito, Masafumi

AU - Ohara, Yuuki

AU - Oda, Yoshinao

AU - Toyokuni, Shinya

N1 - Funding Information: Diagnostics, Aichi Cancer Center Hospital) and Dr Masafumi Ito (Department of Pathology, Nishio Municipal Hospital). This study was supported by JSPS KAKENHI Grant Number JP 16K19079 (K.Y.). This work was presented in part at the 106th Annual Meeting of the United States and Canadian Academy of Pathology in San Antonio, Texas, USA, March 2017. Funding Information: The authors would like to thank the following pathologists who kindly provided case materials: Dr Shigeo Nakamura (Department of Pathology and Laboratory Medicine, Nagoya University Hospital), Dr Yasushi Yatabe (Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital) and Dr Masafumi Ito (Department of Pathology, Nishio Municipal Hospital). This study was supported by JSPS KAKENHI Grant Number JP 16K19079 (K.Y.). This work was presented in part at the 106th Annual Meeting of the United States and Canadian Academy of Pathology in San Antonio, Texas, USA, March 2017. Publisher Copyright: © 2017 John Wiley & Sons Ltd

PY - 2018/4

Y1 - 2018/4

N2 - Aims: Ossification is found occasionally in dedifferentiated liposarcoma (DDLPS). The aims of this study were to elucidate whether the formed bone tissue is usually produced by tumour cells or by reactive non-neoplastic cells, and to reveal the clinicopathological characteristics of DDLPS with ossification. Methods and results: We examined 36 cases of ossified DDLPS by comparing them to 31 cases of non-ossified DDLPS. MDM2 amplification was confirmed in osteocytes and/or osteoblastic cells in all but one ossified DDLPS cases (27 of 28) using fluorescence in-situ hybridisation, although the morphological impression of ossification appeared to be mainly metaplastic (27 of 36) or high-grade osteosarcoma-like (six of 36). The bone tissue was often formed predominantly at the periphery of the DDLPS area near the well-differentiated liposarcoma component (18 of 36), and an organised structure such as bone marrow-like differentiation was not uncommon (12 of 36). According to a modified French Fédération Nationale des Centers de Lutte Contre le Cancer (FNCLCC) grading system, ossified DDLPS tended to be lower grade than non-ossified DDLPS (mean grade: 1.88 and 2.15, respectively). Ossification in DDLPS was associated significantly with shorter local recurrence-free survival by multivariate analysis (P = 0.02347), but metaplastic-appearing ossification tended to be associated with longer overall survival (P = 0.1400). Conclusions: The bone tissue formed in DDLPS was mainly neoplastic regardless of its morphology and maturity, which highlighted the osteogenic differentiation of the tumour cells. DDLPS patients with osteogenic differentiation tended to suffer from earlier local recurrences, which did not necessarily lead to poor life outcomes.

AB - Aims: Ossification is found occasionally in dedifferentiated liposarcoma (DDLPS). The aims of this study were to elucidate whether the formed bone tissue is usually produced by tumour cells or by reactive non-neoplastic cells, and to reveal the clinicopathological characteristics of DDLPS with ossification. Methods and results: We examined 36 cases of ossified DDLPS by comparing them to 31 cases of non-ossified DDLPS. MDM2 amplification was confirmed in osteocytes and/or osteoblastic cells in all but one ossified DDLPS cases (27 of 28) using fluorescence in-situ hybridisation, although the morphological impression of ossification appeared to be mainly metaplastic (27 of 36) or high-grade osteosarcoma-like (six of 36). The bone tissue was often formed predominantly at the periphery of the DDLPS area near the well-differentiated liposarcoma component (18 of 36), and an organised structure such as bone marrow-like differentiation was not uncommon (12 of 36). According to a modified French Fédération Nationale des Centers de Lutte Contre le Cancer (FNCLCC) grading system, ossified DDLPS tended to be lower grade than non-ossified DDLPS (mean grade: 1.88 and 2.15, respectively). Ossification in DDLPS was associated significantly with shorter local recurrence-free survival by multivariate analysis (P = 0.02347), but metaplastic-appearing ossification tended to be associated with longer overall survival (P = 0.1400). Conclusions: The bone tissue formed in DDLPS was mainly neoplastic regardless of its morphology and maturity, which highlighted the osteogenic differentiation of the tumour cells. DDLPS patients with osteogenic differentiation tended to suffer from earlier local recurrences, which did not necessarily lead to poor life outcomes.

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U2 - 10.1111/his.13421

DO - 10.1111/his.13421

M3 - Article

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AN - SCOPUS:85038898982

SN - 0309-0167

VL - 72

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JO - Histopathology

JF - Histopathology

IS - 5

ER -

Osteogenic differentiation in dedifferentiated liposarcoma: a study of 36 cases in comparison to the cases without ossification

Abstract

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