Osteoimmunology: The conceptual framework unifying the immune and skeletal systems

Kazuo Okamoto, Tomoki Nakashima, Masahiro Shinohara, Takako Negishi-Koga, Noriko Komatsu, Asuka Terashima, Shinichiro Sawa, Takeshi Nitta, Hiroshi Takayanagi

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

The immune and skeletal systems share a variety of molecules, including cytokines, chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune cells under physiological and pathological conditions. Osteoimmunology was created as a new interdisciplinary field in large part to highlight the shared molecules and reciprocal interactions between the two systems in both heath and disease. Receptor activator of NF-κB ligand (RANKL) plays an essential role not only in the development of immune organs and bones, but also in autoimmune diseases affecting bone, thus effectively comprising the molecule that links the two systems. Here we review the function, gene regulation, and signal transduction of osteoimmune molecules, including RANKL, in the context of osteoclastogenesis as well as multiple other regulatory functions. Osteoimmunology has become indispensable for understanding the pathogenesis of a number of diseases such as rheumatoid arthritis (RA). We review the various osteoimmune pathologies, including the bone destruction in RA, in which pathogenic helper T cell subsets [such as IL-17-expressing helper T (Th17) cells] induce bone erosion through aberrant RANKL expression.Wealso focus on cellular interactions and the identification of the communication factors in the bone marrow, discussing the contribution of bone cells to the maintenance and regulation of hematopoietic stem and progenitors cells. Thus the time has come for a basic reappraisal of the framework for understanding both the immune and bone systems. The concept of a unified osteoimmune system will be absolutely indispensable for basic and translational approaches to diseases related to bone and/or the immune system.

Original languageEnglish
Pages (from-to)1295-1349
Number of pages55
JournalPhysiological Reviews
Volume97
Issue number4
DOIs
Publication statusPublished - Oct 1 2017
Externally publishedYes

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Immune System
Bone and Bones
Hematopoietic Stem Cells
Helper-Inducer T-Lymphocytes
Rheumatoid Arthritis
Th17 Cells
Interleukin-17
Chemokine Receptors
T-Lymphocyte Subsets
Osteogenesis
Autoimmune Diseases
Signal Transduction
Transcription Factors
Bone Marrow
Maintenance
Hormones
Pathology
Cytokines
Ligands
Genes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Molecular Biology
  • Physiology (medical)

Cite this

Okamoto, K., Nakashima, T., Shinohara, M., Negishi-Koga, T., Komatsu, N., Terashima, A., ... Takayanagi, H. (2017). Osteoimmunology: The conceptual framework unifying the immune and skeletal systems. Physiological Reviews, 97(4), 1295-1349. https://doi.org/10.1152/physrev.00036.2016

Osteoimmunology : The conceptual framework unifying the immune and skeletal systems. / Okamoto, Kazuo; Nakashima, Tomoki; Shinohara, Masahiro; Negishi-Koga, Takako; Komatsu, Noriko; Terashima, Asuka; Sawa, Shinichiro; Nitta, Takeshi; Takayanagi, Hiroshi.

In: Physiological Reviews, Vol. 97, No. 4, 01.10.2017, p. 1295-1349.

Research output: Contribution to journalArticle

Okamoto, K, Nakashima, T, Shinohara, M, Negishi-Koga, T, Komatsu, N, Terashima, A, Sawa, S, Nitta, T & Takayanagi, H 2017, 'Osteoimmunology: The conceptual framework unifying the immune and skeletal systems', Physiological Reviews, vol. 97, no. 4, pp. 1295-1349. https://doi.org/10.1152/physrev.00036.2016
Okamoto K, Nakashima T, Shinohara M, Negishi-Koga T, Komatsu N, Terashima A et al. Osteoimmunology: The conceptual framework unifying the immune and skeletal systems. Physiological Reviews. 2017 Oct 1;97(4):1295-1349. https://doi.org/10.1152/physrev.00036.2016
Okamoto, Kazuo ; Nakashima, Tomoki ; Shinohara, Masahiro ; Negishi-Koga, Takako ; Komatsu, Noriko ; Terashima, Asuka ; Sawa, Shinichiro ; Nitta, Takeshi ; Takayanagi, Hiroshi. / Osteoimmunology : The conceptual framework unifying the immune and skeletal systems. In: Physiological Reviews. 2017 ; Vol. 97, No. 4. pp. 1295-1349.
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