Osteoporotic Changes in the Periodontium Impair Alveolar Bone Healing

masaki arioka, X. Zhang, Z. Li, U. S. Tulu, Y. Liu, L. Wang, X. Yuan, J. A. Helms

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Osteoporosis is associated with decreased bone density and increased bone fragility, but how this disease affects alveolar bone healing is not clear. The objective of this study was to determine the extent to which osteoporosis affects the jaw skeleton and then to evaluate possible mechanisms whereby an osteoporotic phenotype might affect the rate of alveolar bone healing following tooth extraction. Using an ovariectomized mouse model coupled with micro–computed tomographic imaging, histologic, molecular, and cellular assays, we first demonstrated that the appendicular and jaw skeletons both develop osteoporotic phenotypes. Next, we demonstrated that osteoporotic mice exhibit atrophy of the periodontal ligament (PDL) and that this atrophy was accompanied by a reduction in the pool of osteoprogenitor cells in the PDL. The paucity of PDL-derived osteoprogenitor cells in osteoporotic mice was associated with significantly slower extraction socket healing. Collectively, these analyses demonstrate that the jaw skeleton is susceptible to the untoward effects of osteoporosis that manifest as thinner, more porous alveolar bone, PDL thinning, and slower bone repair. These findings have potential clinical significance for older osteopenic patients undergoing reconstructive procedures.

Original languageEnglish
Pages (from-to)450-458
Number of pages9
JournalJournal of Dental Research
Volume98
Issue number4
DOIs
Publication statusPublished - Apr 1 2019

Fingerprint

Periodontium
Periodontal Ligament
Jaw
Skeleton
Osteoporosis
Bone and Bones
Periodontal Atrophy
Phenotype
Tooth Extraction
Molecular Imaging
Bone Diseases
Bone Density
Atrophy

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

arioka, M., Zhang, X., Li, Z., Tulu, U. S., Liu, Y., Wang, L., ... Helms, J. A. (2019). Osteoporotic Changes in the Periodontium Impair Alveolar Bone Healing. Journal of Dental Research, 98(4), 450-458. https://doi.org/10.1177/0022034518818456

Osteoporotic Changes in the Periodontium Impair Alveolar Bone Healing. / arioka, masaki; Zhang, X.; Li, Z.; Tulu, U. S.; Liu, Y.; Wang, L.; Yuan, X.; Helms, J. A.

In: Journal of Dental Research, Vol. 98, No. 4, 01.04.2019, p. 450-458.

Research output: Contribution to journalArticle

arioka, M, Zhang, X, Li, Z, Tulu, US, Liu, Y, Wang, L, Yuan, X & Helms, JA 2019, 'Osteoporotic Changes in the Periodontium Impair Alveolar Bone Healing', Journal of Dental Research, vol. 98, no. 4, pp. 450-458. https://doi.org/10.1177/0022034518818456
arioka, masaki ; Zhang, X. ; Li, Z. ; Tulu, U. S. ; Liu, Y. ; Wang, L. ; Yuan, X. ; Helms, J. A. / Osteoporotic Changes in the Periodontium Impair Alveolar Bone Healing. In: Journal of Dental Research. 2019 ; Vol. 98, No. 4. pp. 450-458.
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