OTotoxicity Of Povidone-Iodine Applied To The Middle Ear Cavity Of Guinea Pigs

T. Ichibangase, T. Yamano, M. Miyagi, T. Nakagawa, T. Morizono

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: Povidone-Iodine preparation is used as a disinfectant in otological surgeries. The ototoxicity of Povidone-Iodine preparation was evaluated using infant, young and adult guinea pigs. The effects of different concentrations and of different exposure durations on compound action potentials were also studied. Materials & methods: Povidone-Iodine was used to fill one middle ear cavity of the guinea pig, and the compound action potential (CAP) was measured from the round window membrane at 24. h, 7 days, and 28 days. The contralateral side was filled with saline as control. Test sounds used were clicks and tone bursts of 2, 4, and 8. kHz. Results: At 24. h, Povidone-Iodine solution showed a significant toxic effect in the infant group. In the young animal group, no toxic effect was seen. In the adult group, a mild degree of deafness for 2. kHz was found. At 7 days, the young group showed significant hearing loss for all frequencies, but the adult group did not show any hearing loss. With a half strength solution, both young and adult group did not show hearing loss.At 28 days, with a full strength solution, hearing loss became prominent for all sound stimulation. With 1/8th dilution, the young group showed a moderate hearing loss, but the adult group did not. Conclusion: The thicker round window membrane in human is expected to provide more protection to the human cochlea than in the guinea pig model that we have studied. Mild hearing loss at 24. h and 7 days using 10% solution, but no hearing loss with 5% solution at 7 days may indicate that rinsing of the middle ear cavity with saline during surgery should minimize the ototoxic effect of this product.The age of the animals does influence the outcome of the ototoxicity experiment.From this experiment, Povidone-Iodine preparations in the infant should be used with caution. Povidone scrub should not be used for otologic surgery.

Original languageEnglish
Pages (from-to)1078-1081
Number of pages4
JournalInternational Journal of Pediatric Otorhinolaryngology
Volume75
Issue number9
DOIs
Publication statusPublished - Sep 1 2011
Externally publishedYes

Fingerprint

Povidone-Iodine
Middle Ear
Hearing Loss
Guinea Pigs
Poisons
Action Potentials
Young Adult
Povidone
Membranes
Disinfectants
Cochlea
Deafness

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Otorhinolaryngology

Cite this

OTotoxicity Of Povidone-Iodine Applied To The Middle Ear Cavity Of Guinea Pigs. / Ichibangase, T.; Yamano, T.; Miyagi, M.; Nakagawa, T.; Morizono, T.

In: International Journal of Pediatric Otorhinolaryngology, Vol. 75, No. 9, 01.09.2011, p. 1078-1081.

Research output: Contribution to journalArticle

Ichibangase, T. ; Yamano, T. ; Miyagi, M. ; Nakagawa, T. ; Morizono, T. / OTotoxicity Of Povidone-Iodine Applied To The Middle Ear Cavity Of Guinea Pigs. In: International Journal of Pediatric Otorhinolaryngology. 2011 ; Vol. 75, No. 9. pp. 1078-1081.
@article{77eba8c43e3e4faaafb808139e50ffda,
title = "OTotoxicity Of Povidone-Iodine Applied To The Middle Ear Cavity Of Guinea Pigs",
abstract = "Objective: Povidone-Iodine preparation is used as a disinfectant in otological surgeries. The ototoxicity of Povidone-Iodine preparation was evaluated using infant, young and adult guinea pigs. The effects of different concentrations and of different exposure durations on compound action potentials were also studied. Materials & methods: Povidone-Iodine was used to fill one middle ear cavity of the guinea pig, and the compound action potential (CAP) was measured from the round window membrane at 24. h, 7 days, and 28 days. The contralateral side was filled with saline as control. Test sounds used were clicks and tone bursts of 2, 4, and 8. kHz. Results: At 24. h, Povidone-Iodine solution showed a significant toxic effect in the infant group. In the young animal group, no toxic effect was seen. In the adult group, a mild degree of deafness for 2. kHz was found. At 7 days, the young group showed significant hearing loss for all frequencies, but the adult group did not show any hearing loss. With a half strength solution, both young and adult group did not show hearing loss.At 28 days, with a full strength solution, hearing loss became prominent for all sound stimulation. With 1/8th dilution, the young group showed a moderate hearing loss, but the adult group did not. Conclusion: The thicker round window membrane in human is expected to provide more protection to the human cochlea than in the guinea pig model that we have studied. Mild hearing loss at 24. h and 7 days using 10{\%} solution, but no hearing loss with 5{\%} solution at 7 days may indicate that rinsing of the middle ear cavity with saline during surgery should minimize the ototoxic effect of this product.The age of the animals does influence the outcome of the ototoxicity experiment.From this experiment, Povidone-Iodine preparations in the infant should be used with caution. Povidone scrub should not be used for otologic surgery.",
author = "T. Ichibangase and T. Yamano and M. Miyagi and T. Nakagawa and T. Morizono",
year = "2011",
month = "9",
day = "1",
doi = "10.1016/j.ijporl.2011.05.013",
language = "English",
volume = "75",
pages = "1078--1081",
journal = "International Journal of Pediatric Otorhinolaryngology",
issn = "0165-5876",
publisher = "Elsevier Ireland Ltd",
number = "9",

}

TY - JOUR

T1 - OTotoxicity Of Povidone-Iodine Applied To The Middle Ear Cavity Of Guinea Pigs

AU - Ichibangase, T.

AU - Yamano, T.

AU - Miyagi, M.

AU - Nakagawa, T.

AU - Morizono, T.

PY - 2011/9/1

Y1 - 2011/9/1

N2 - Objective: Povidone-Iodine preparation is used as a disinfectant in otological surgeries. The ototoxicity of Povidone-Iodine preparation was evaluated using infant, young and adult guinea pigs. The effects of different concentrations and of different exposure durations on compound action potentials were also studied. Materials & methods: Povidone-Iodine was used to fill one middle ear cavity of the guinea pig, and the compound action potential (CAP) was measured from the round window membrane at 24. h, 7 days, and 28 days. The contralateral side was filled with saline as control. Test sounds used were clicks and tone bursts of 2, 4, and 8. kHz. Results: At 24. h, Povidone-Iodine solution showed a significant toxic effect in the infant group. In the young animal group, no toxic effect was seen. In the adult group, a mild degree of deafness for 2. kHz was found. At 7 days, the young group showed significant hearing loss for all frequencies, but the adult group did not show any hearing loss. With a half strength solution, both young and adult group did not show hearing loss.At 28 days, with a full strength solution, hearing loss became prominent for all sound stimulation. With 1/8th dilution, the young group showed a moderate hearing loss, but the adult group did not. Conclusion: The thicker round window membrane in human is expected to provide more protection to the human cochlea than in the guinea pig model that we have studied. Mild hearing loss at 24. h and 7 days using 10% solution, but no hearing loss with 5% solution at 7 days may indicate that rinsing of the middle ear cavity with saline during surgery should minimize the ototoxic effect of this product.The age of the animals does influence the outcome of the ototoxicity experiment.From this experiment, Povidone-Iodine preparations in the infant should be used with caution. Povidone scrub should not be used for otologic surgery.

AB - Objective: Povidone-Iodine preparation is used as a disinfectant in otological surgeries. The ototoxicity of Povidone-Iodine preparation was evaluated using infant, young and adult guinea pigs. The effects of different concentrations and of different exposure durations on compound action potentials were also studied. Materials & methods: Povidone-Iodine was used to fill one middle ear cavity of the guinea pig, and the compound action potential (CAP) was measured from the round window membrane at 24. h, 7 days, and 28 days. The contralateral side was filled with saline as control. Test sounds used were clicks and tone bursts of 2, 4, and 8. kHz. Results: At 24. h, Povidone-Iodine solution showed a significant toxic effect in the infant group. In the young animal group, no toxic effect was seen. In the adult group, a mild degree of deafness for 2. kHz was found. At 7 days, the young group showed significant hearing loss for all frequencies, but the adult group did not show any hearing loss. With a half strength solution, both young and adult group did not show hearing loss.At 28 days, with a full strength solution, hearing loss became prominent for all sound stimulation. With 1/8th dilution, the young group showed a moderate hearing loss, but the adult group did not. Conclusion: The thicker round window membrane in human is expected to provide more protection to the human cochlea than in the guinea pig model that we have studied. Mild hearing loss at 24. h and 7 days using 10% solution, but no hearing loss with 5% solution at 7 days may indicate that rinsing of the middle ear cavity with saline during surgery should minimize the ototoxic effect of this product.The age of the animals does influence the outcome of the ototoxicity experiment.From this experiment, Povidone-Iodine preparations in the infant should be used with caution. Povidone scrub should not be used for otologic surgery.

UR - http://www.scopus.com/inward/record.url?scp=80051865825&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80051865825&partnerID=8YFLogxK

U2 - 10.1016/j.ijporl.2011.05.013

DO - 10.1016/j.ijporl.2011.05.013

M3 - Article

C2 - 21741096

AN - SCOPUS:80051865825

VL - 75

SP - 1078

EP - 1081

JO - International Journal of Pediatric Otorhinolaryngology

JF - International Journal of Pediatric Otorhinolaryngology

SN - 0165-5876

IS - 9

ER -