Outcome differences between children and adolescents and young adults with non-Hodgkin lymphoma following stem cell transplantation

Ryoji Kobayashi, Tetsuo Mitsui, Naoto Fujita, Tomoo Osumi, Tomohiro Aoki, Kazunari Aoki, Ritsuro Suzuki, Takahiro Fukuda, Toshihiro Miyamoto, Koji Kato, Hirohisa Nakamae, Hiroaki Goto, Tetsuya Eto, Masami Inoue, Takehiko Mori, Kiminori Terui, Masahito Onizuka, Katsuyoshi Koh, Yuhki Koga, Tatsuo Ichinohe & 3 others Akihisa Sawada, Yoshiko Atsuta, Junji Suzumiya

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3 Citations (Scopus)

Abstract

Several studies of patients with acute lymphoblastic leukemia and acute myeloid leukemia who received stem cell transplantation (SCT) have reported that adolescents and young adults (AYAs) experience higher transplant-related mortality than that in younger children. However, to the best of our knowledge, there have been no reports of a similar comparison of non-Hodgkin lymphoma (NHL) patients who received SCT. We analyzed 918 patients aged 30 years and younger who received their first stem cell transplantation for NHL. Of the allogeneic transplant patients, children and AYAs did not significantly differ in survival rate, event-free survival rate, relapse rate, or transplant-related mortality. However, 5-year transplant-related mortality after autologous transplantation was significantly higher in children than in AYAs (5.1% in children vs. 0.8% in AYAs, P = 0.0043). The cause of transplant-related death in three of four children was interstitial pneumonitis. In NHL patients, transplantation results in AYAs were not inferior than those in children.

Original languageEnglish
Pages (from-to)369-376
Number of pages8
JournalInternational journal of hematology
Volume105
Issue number3
DOIs
Publication statusPublished - Mar 1 2017

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Stem Cell Transplantation
Non-Hodgkin's Lymphoma
Young Adult
Transplants
Mortality
Survival Rate
Autologous Transplantation
Interstitial Lung Diseases
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute Myeloid Leukemia
Disease-Free Survival
Transplantation
Recurrence

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Outcome differences between children and adolescents and young adults with non-Hodgkin lymphoma following stem cell transplantation. / Kobayashi, Ryoji; Mitsui, Tetsuo; Fujita, Naoto; Osumi, Tomoo; Aoki, Tomohiro; Aoki, Kazunari; Suzuki, Ritsuro; Fukuda, Takahiro; Miyamoto, Toshihiro; Kato, Koji; Nakamae, Hirohisa; Goto, Hiroaki; Eto, Tetsuya; Inoue, Masami; Mori, Takehiko; Terui, Kiminori; Onizuka, Masahito; Koh, Katsuyoshi; Koga, Yuhki; Ichinohe, Tatsuo; Sawada, Akihisa; Atsuta, Yoshiko; Suzumiya, Junji.

In: International journal of hematology, Vol. 105, No. 3, 01.03.2017, p. 369-376.

Research output: Contribution to journalArticle

Kobayashi, R, Mitsui, T, Fujita, N, Osumi, T, Aoki, T, Aoki, K, Suzuki, R, Fukuda, T, Miyamoto, T, Kato, K, Nakamae, H, Goto, H, Eto, T, Inoue, M, Mori, T, Terui, K, Onizuka, M, Koh, K, Koga, Y, Ichinohe, T, Sawada, A, Atsuta, Y & Suzumiya, J 2017, 'Outcome differences between children and adolescents and young adults with non-Hodgkin lymphoma following stem cell transplantation', International journal of hematology, vol. 105, no. 3, pp. 369-376. https://doi.org/10.1007/s12185-016-2120-1
Kobayashi, Ryoji ; Mitsui, Tetsuo ; Fujita, Naoto ; Osumi, Tomoo ; Aoki, Tomohiro ; Aoki, Kazunari ; Suzuki, Ritsuro ; Fukuda, Takahiro ; Miyamoto, Toshihiro ; Kato, Koji ; Nakamae, Hirohisa ; Goto, Hiroaki ; Eto, Tetsuya ; Inoue, Masami ; Mori, Takehiko ; Terui, Kiminori ; Onizuka, Masahito ; Koh, Katsuyoshi ; Koga, Yuhki ; Ichinohe, Tatsuo ; Sawada, Akihisa ; Atsuta, Yoshiko ; Suzumiya, Junji. / Outcome differences between children and adolescents and young adults with non-Hodgkin lymphoma following stem cell transplantation. In: International journal of hematology. 2017 ; Vol. 105, No. 3. pp. 369-376.
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AU - Aoki, Tomohiro

AU - Aoki, Kazunari

AU - Suzuki, Ritsuro

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AU - Onizuka, Masahito

AU - Koh, Katsuyoshi

AU - Koga, Yuhki

AU - Ichinohe, Tatsuo

AU - Sawada, Akihisa

AU - Atsuta, Yoshiko

AU - Suzumiya, Junji

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N2 - Several studies of patients with acute lymphoblastic leukemia and acute myeloid leukemia who received stem cell transplantation (SCT) have reported that adolescents and young adults (AYAs) experience higher transplant-related mortality than that in younger children. However, to the best of our knowledge, there have been no reports of a similar comparison of non-Hodgkin lymphoma (NHL) patients who received SCT. We analyzed 918 patients aged 30 years and younger who received their first stem cell transplantation for NHL. Of the allogeneic transplant patients, children and AYAs did not significantly differ in survival rate, event-free survival rate, relapse rate, or transplant-related mortality. However, 5-year transplant-related mortality after autologous transplantation was significantly higher in children than in AYAs (5.1% in children vs. 0.8% in AYAs, P = 0.0043). The cause of transplant-related death in three of four children was interstitial pneumonitis. In NHL patients, transplantation results in AYAs were not inferior than those in children.

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