Outcome in VLBW infants with surgical intestinal disorder at 18-months of corrected age

Masahiro Hayakawa, Tomoaki Taguchi, Naoto Urushihara, Akiko Yokoi, Hiroshi Take, Jun Shiraishi, Hideshi Fujinaga, Kensuke Ohashi, Makoto Oshiro, Yuichi Kato, Satoko Ohfuji, Hiroomi Okuyama

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background Surgical intestinal disorders, such as necrotizing enterocolitis (NEC), focal intestinal perforation (FIP), and meconium-related ileus (MRI), are serious morbidities in very low-birthweight infants (VLBWI). The aim of this study was to compare the composite outcomes of death or neurodevelopmental impairment (NDI) in VLBWI with surgical intestinal disorders and assess independent risk factors for death and NDI at 18-months of corrected age. Methods A retrospective matched-cohort study was conducted at 11 institutes. We included VLBWI who had undergone laparotomy for NEC, FIP, and MRI. Two control subjects were chosen for every surgical patient and matched for gestational age and birthweight to form the comparison group. Death and neurodevelopmental outcome at 18-months of corrected age were evaluated. Results The number of infants in the NEC, FIP, MRI, and control groups was 44, 47, 42, and 261, respectively. In-hospital mortality was higher in infants with NEC and MRI relative to those in the control group (P < 0.001). The incidence rate for NDI at 18-months of corrected age was higher in infants with MRI relative to those in the control group (P = 0.021). On logistic regression analysis, low gestational age, male sex, small for gestational age, intraventricular hemorrhage, and MRI were associated with increased risk of death or NDI at 18-months of corrected age. Conclusions NEC and MRI were associated with in-hospital mortality, and MRI was associated with NDI or death at 18-months of corrected age.

Original languageEnglish
Pages (from-to)633-638
Number of pages6
JournalPediatrics International
Volume57
Issue number4
DOIs
Publication statusPublished - Jan 1 2015

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Meconium
Ileus
Necrotizing Enterocolitis
Intestinal Perforation
Gestational Age
Hospital Mortality
Control Groups
Laparotomy
Cohort Studies
Logistic Models
Regression Analysis
Hemorrhage
Morbidity
Incidence

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Hayakawa, M., Taguchi, T., Urushihara, N., Yokoi, A., Take, H., Shiraishi, J., ... Okuyama, H. (2015). Outcome in VLBW infants with surgical intestinal disorder at 18-months of corrected age. Pediatrics International, 57(4), 633-638. https://doi.org/10.1111/ped.12594

Outcome in VLBW infants with surgical intestinal disorder at 18-months of corrected age. / Hayakawa, Masahiro; Taguchi, Tomoaki; Urushihara, Naoto; Yokoi, Akiko; Take, Hiroshi; Shiraishi, Jun; Fujinaga, Hideshi; Ohashi, Kensuke; Oshiro, Makoto; Kato, Yuichi; Ohfuji, Satoko; Okuyama, Hiroomi.

In: Pediatrics International, Vol. 57, No. 4, 01.01.2015, p. 633-638.

Research output: Contribution to journalArticle

Hayakawa, M, Taguchi, T, Urushihara, N, Yokoi, A, Take, H, Shiraishi, J, Fujinaga, H, Ohashi, K, Oshiro, M, Kato, Y, Ohfuji, S & Okuyama, H 2015, 'Outcome in VLBW infants with surgical intestinal disorder at 18-months of corrected age', Pediatrics International, vol. 57, no. 4, pp. 633-638. https://doi.org/10.1111/ped.12594
Hayakawa, Masahiro ; Taguchi, Tomoaki ; Urushihara, Naoto ; Yokoi, Akiko ; Take, Hiroshi ; Shiraishi, Jun ; Fujinaga, Hideshi ; Ohashi, Kensuke ; Oshiro, Makoto ; Kato, Yuichi ; Ohfuji, Satoko ; Okuyama, Hiroomi. / Outcome in VLBW infants with surgical intestinal disorder at 18-months of corrected age. In: Pediatrics International. 2015 ; Vol. 57, No. 4. pp. 633-638.
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abstract = "Background Surgical intestinal disorders, such as necrotizing enterocolitis (NEC), focal intestinal perforation (FIP), and meconium-related ileus (MRI), are serious morbidities in very low-birthweight infants (VLBWI). The aim of this study was to compare the composite outcomes of death or neurodevelopmental impairment (NDI) in VLBWI with surgical intestinal disorders and assess independent risk factors for death and NDI at 18-months of corrected age. Methods A retrospective matched-cohort study was conducted at 11 institutes. We included VLBWI who had undergone laparotomy for NEC, FIP, and MRI. Two control subjects were chosen for every surgical patient and matched for gestational age and birthweight to form the comparison group. Death and neurodevelopmental outcome at 18-months of corrected age were evaluated. Results The number of infants in the NEC, FIP, MRI, and control groups was 44, 47, 42, and 261, respectively. In-hospital mortality was higher in infants with NEC and MRI relative to those in the control group (P < 0.001). The incidence rate for NDI at 18-months of corrected age was higher in infants with MRI relative to those in the control group (P = 0.021). On logistic regression analysis, low gestational age, male sex, small for gestational age, intraventricular hemorrhage, and MRI were associated with increased risk of death or NDI at 18-months of corrected age. Conclusions NEC and MRI were associated with in-hospital mortality, and MRI was associated with NDI or death at 18-months of corrected age.",
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AU - Take, Hiroshi

AU - Shiraishi, Jun

AU - Fujinaga, Hideshi

AU - Ohashi, Kensuke

AU - Oshiro, Makoto

AU - Kato, Yuichi

AU - Ohfuji, Satoko

AU - Okuyama, Hiroomi

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N2 - Background Surgical intestinal disorders, such as necrotizing enterocolitis (NEC), focal intestinal perforation (FIP), and meconium-related ileus (MRI), are serious morbidities in very low-birthweight infants (VLBWI). The aim of this study was to compare the composite outcomes of death or neurodevelopmental impairment (NDI) in VLBWI with surgical intestinal disorders and assess independent risk factors for death and NDI at 18-months of corrected age. Methods A retrospective matched-cohort study was conducted at 11 institutes. We included VLBWI who had undergone laparotomy for NEC, FIP, and MRI. Two control subjects were chosen for every surgical patient and matched for gestational age and birthweight to form the comparison group. Death and neurodevelopmental outcome at 18-months of corrected age were evaluated. Results The number of infants in the NEC, FIP, MRI, and control groups was 44, 47, 42, and 261, respectively. In-hospital mortality was higher in infants with NEC and MRI relative to those in the control group (P < 0.001). The incidence rate for NDI at 18-months of corrected age was higher in infants with MRI relative to those in the control group (P = 0.021). On logistic regression analysis, low gestational age, male sex, small for gestational age, intraventricular hemorrhage, and MRI were associated with increased risk of death or NDI at 18-months of corrected age. Conclusions NEC and MRI were associated with in-hospital mortality, and MRI was associated with NDI or death at 18-months of corrected age.

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