Outcome of childhood acute lymphoblastic leukemia with induction failure treated by the Japan Association of Childhood Leukemia Study (JACLS) ALL F-protocol

Nobuhiro Suzuki, Keiko Yumura-Yagi, Makoto Yoshida, Junichi Hara, Shinichiro Nishimura, Tooru Kudoh, Akio Tawa, Ikuya Usami, Akihiko Tanizawa, Hiroki Hori, Yasuhiko Ito, Ryosuke Miyaji, Megumi Oda, Koji Kato, Kazuko Hamamoto, Yuko Osugi, Yoshiko Hashii, Tatsutoshi Nakahata, Keizo Horibe

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22 Citations (Scopus)

Abstract

Background. Children with acute lymphoblastic leukemia (ALL) who fail to achieve complete remission (CR) after induction therapy (induction failure: IF) have a poor prognosis; however, there have been few prospective studies in patients with IF. Patients and Methods. Between April 1997 and March 2005, 27 of 1,237 leukemic patients (2.2%) failed to achieve CR after four- or five-drug induction therapy. Twenty-three of these patients entered the F-protocol study, which mainly consisted of acute-myeloid-leukemia-oriented chemotherapy followed by scheduled hematopoietic cell transplantation (HCT). Results. Seventeen (73.9%) of the 23 patients responded to re-induction chemotherapy with CR. Of note, 15 (93.8%) of 16 patients with Philadelphia-chromosome-negative (non-Ph+) ALL achieved CR; in contrast, only 2 (28.6%) of 7 Ph + patients achieved CR. Fourteen (82.4%) of 17 patients remained in CR (CCR) until their scheduled HCT, 12 of the 14 with CCR underwent HCT as scheduled, and 6 patients remain in first CR after a median of 78 months (range, 49-107 months). The 5-year overall survival (OS) rates of 16 patients with non-Ph+ and 7 patients with Ph+ were 43.8±12.4% and 14.3±13.2%, respectively (P=0.012). The 5-year OS rate of the 17 patients who obtained CR by re-induction therapy and the 6 who did not were 47.1±12.1% and 0%, respectively (P<0.001). Conclusion. Acute-myeloid-leukemia-oriented chemotherapy followed by scheduled HCT is a promising treatment strategy for non-Ph+ ALL patients with IF.

Original languageEnglish
Pages (from-to)71-78
Number of pages8
JournalPediatric Blood and Cancer
Volume54
Issue number1
DOIs
Publication statusPublished - Jan 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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