Outcome of repeat hepatectomy in patients with hepatocellular carcinoma aged 75 years and older

Eiji Tsujita, Tohru Utsunomiya, Mitsuhiko Ohta, Tetsuzo Tagawa, Ayumu Matsuyama, Jin Okazaki, Manabu Yamamoto, Shin ichi Tsutsui, Teruyoshi Ishida

Research output: Contribution to journalArticle

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Abstract

Background: We sought to evaluate the influence of age on the outcome of repeat hepatectomies in patients ≥75 years with recurrent hepatocellular carcinoma (HCC). Methods: We studied 121 curative repeat hepatectomies retrospectively. Among the 121 patients, 100, 20, and 1 received second, third, and fourth hepatectomies, respectively. The short-term surgical results of a younger group (<75 years; n = 88) and those of an elderly group (≥75 years; n = 33) were compared. The long-term prognosis of the patients who underwent second hepatectomies was also compared between a younger group (<75 years; n = 77) and an elderly group (≥75 years; n = 23). Results: The patients in the elderly group displayed more comorbid conditions pre-operatively, including hypertension and cardiovascular diseases, than the younger group (P < .05); however, there was no significant difference in the incidence of postoperative complications or the duration of postoperative hospital stay. The long-term prognosis in the elderly group was almost identical to that in the younger group. The 3-year overall survival rates for the younger group and the elderly group were 83 vs 73% (P = .51). Disease-free, 3-year survival rates for the younger group and the elderly group were 35% vs 38% (P = .88). Conclusion: Our findings suggest that advanced age by itself does not have an adverse effect on operative outcomes, including postoperative complications and long-term prognosis. Repeat hepatectomy may, therefore, be justified for recurrent HCC in selected elderly patients.

Original languageEnglish
Pages (from-to)696-703
Number of pages8
JournalSurgery
Volume147
Issue number5
DOIs
Publication statusPublished - May 1 2010
Externally publishedYes

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Hepatectomy
Hepatocellular Carcinoma
Survival Rate
Length of Stay
Cardiovascular Diseases
Hypertension
Incidence

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Tsujita, E., Utsunomiya, T., Ohta, M., Tagawa, T., Matsuyama, A., Okazaki, J., ... Ishida, T. (2010). Outcome of repeat hepatectomy in patients with hepatocellular carcinoma aged 75 years and older. Surgery, 147(5), 696-703. https://doi.org/10.1016/j.surg.2009.10.054

Outcome of repeat hepatectomy in patients with hepatocellular carcinoma aged 75 years and older. / Tsujita, Eiji; Utsunomiya, Tohru; Ohta, Mitsuhiko; Tagawa, Tetsuzo; Matsuyama, Ayumu; Okazaki, Jin; Yamamoto, Manabu; Tsutsui, Shin ichi; Ishida, Teruyoshi.

In: Surgery, Vol. 147, No. 5, 01.05.2010, p. 696-703.

Research output: Contribution to journalArticle

Tsujita, E, Utsunomiya, T, Ohta, M, Tagawa, T, Matsuyama, A, Okazaki, J, Yamamoto, M, Tsutsui, SI & Ishida, T 2010, 'Outcome of repeat hepatectomy in patients with hepatocellular carcinoma aged 75 years and older', Surgery, vol. 147, no. 5, pp. 696-703. https://doi.org/10.1016/j.surg.2009.10.054
Tsujita, Eiji ; Utsunomiya, Tohru ; Ohta, Mitsuhiko ; Tagawa, Tetsuzo ; Matsuyama, Ayumu ; Okazaki, Jin ; Yamamoto, Manabu ; Tsutsui, Shin ichi ; Ishida, Teruyoshi. / Outcome of repeat hepatectomy in patients with hepatocellular carcinoma aged 75 years and older. In: Surgery. 2010 ; Vol. 147, No. 5. pp. 696-703.
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AU - Utsunomiya, Tohru

AU - Ohta, Mitsuhiko

AU - Tagawa, Tetsuzo

AU - Matsuyama, Ayumu

AU - Okazaki, Jin

AU - Yamamoto, Manabu

AU - Tsutsui, Shin ichi

AU - Ishida, Teruyoshi

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N2 - Background: We sought to evaluate the influence of age on the outcome of repeat hepatectomies in patients ≥75 years with recurrent hepatocellular carcinoma (HCC). Methods: We studied 121 curative repeat hepatectomies retrospectively. Among the 121 patients, 100, 20, and 1 received second, third, and fourth hepatectomies, respectively. The short-term surgical results of a younger group (<75 years; n = 88) and those of an elderly group (≥75 years; n = 33) were compared. The long-term prognosis of the patients who underwent second hepatectomies was also compared between a younger group (<75 years; n = 77) and an elderly group (≥75 years; n = 23). Results: The patients in the elderly group displayed more comorbid conditions pre-operatively, including hypertension and cardiovascular diseases, than the younger group (P < .05); however, there was no significant difference in the incidence of postoperative complications or the duration of postoperative hospital stay. The long-term prognosis in the elderly group was almost identical to that in the younger group. The 3-year overall survival rates for the younger group and the elderly group were 83 vs 73% (P = .51). Disease-free, 3-year survival rates for the younger group and the elderly group were 35% vs 38% (P = .88). Conclusion: Our findings suggest that advanced age by itself does not have an adverse effect on operative outcomes, including postoperative complications and long-term prognosis. Repeat hepatectomy may, therefore, be justified for recurrent HCC in selected elderly patients.

AB - Background: We sought to evaluate the influence of age on the outcome of repeat hepatectomies in patients ≥75 years with recurrent hepatocellular carcinoma (HCC). Methods: We studied 121 curative repeat hepatectomies retrospectively. Among the 121 patients, 100, 20, and 1 received second, third, and fourth hepatectomies, respectively. The short-term surgical results of a younger group (<75 years; n = 88) and those of an elderly group (≥75 years; n = 33) were compared. The long-term prognosis of the patients who underwent second hepatectomies was also compared between a younger group (<75 years; n = 77) and an elderly group (≥75 years; n = 23). Results: The patients in the elderly group displayed more comorbid conditions pre-operatively, including hypertension and cardiovascular diseases, than the younger group (P < .05); however, there was no significant difference in the incidence of postoperative complications or the duration of postoperative hospital stay. The long-term prognosis in the elderly group was almost identical to that in the younger group. The 3-year overall survival rates for the younger group and the elderly group were 83 vs 73% (P = .51). Disease-free, 3-year survival rates for the younger group and the elderly group were 35% vs 38% (P = .88). Conclusion: Our findings suggest that advanced age by itself does not have an adverse effect on operative outcomes, including postoperative complications and long-term prognosis. Repeat hepatectomy may, therefore, be justified for recurrent HCC in selected elderly patients.

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