Background The object of the current study was to review the outcomes of hepatic resection for hepatocellular carcinoma (HCC)10cm. Methods Between 1995 and 2007, fifty-three patients with HCC-0cm underwent hepatic resection, and clinical data were compared to those of patients with non-surgical treatment (n=12). Surgical results for HCC-10cm were compared to those of patients with HCC<10cm (n=412). The independent poor prognostic factors of the patients with HCC-10cm were identified. Results Overall survival was significantly better in patients with hepatic resection for HCC-10cm than in those with non-surgical treatment (P<0.01). Survival rates of patients with hepatic resection for HCC-10cm were 35% at 5 years. Morbidity and mortality rate were statistically equal. The independent poor prognostic factors of patients with hepatic resection for HCC-10cm were revealed: T4 status, macroscopic tumor thrombus in portal vein (VP+), and the use of intra-operative transfusion. Conclusion Hepatic resections for HCC-10cm are safe and efficacious. Minimizing intra-operative blood loss and the establishment of an effective systemic treatment for patients with HCC-10cm in T4 appear to be critical.
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