Outcomes of hepatic resection for huge hepatocellular carcinoma (a≥10cm in diameter)

Yo Ichi Yamashita, Akinobu Taketomi, Ken Shirabe, Shinichi Aishima, Eiji Tsuijita, Kazutoyo Morita, Hiroto Kayashima, Yoshihiko Maehara

Research output: Contribution to journalReview article

52 Citations (Scopus)

Abstract

Background The object of the current study was to review the outcomes of hepatic resection for hepatocellular carcinoma (HCC)10cm. Methods Between 1995 and 2007, fifty-three patients with HCC-0cm underwent hepatic resection, and clinical data were compared to those of patients with non-surgical treatment (n=12). Surgical results for HCC-10cm were compared to those of patients with HCC<10cm (n=412). The independent poor prognostic factors of the patients with HCC-10cm were identified. Results Overall survival was significantly better in patients with hepatic resection for HCC-10cm than in those with non-surgical treatment (P<0.01). Survival rates of patients with hepatic resection for HCC-10cm were 35% at 5 years. Morbidity and mortality rate were statistically equal. The independent poor prognostic factors of patients with hepatic resection for HCC-10cm were revealed: T4 status, macroscopic tumor thrombus in portal vein (VP+), and the use of intra-operative transfusion. Conclusion Hepatic resections for HCC-10cm are safe and efficacious. Minimizing intra-operative blood loss and the establishment of an effective systemic treatment for patients with HCC-10cm in T4 appear to be critical.

Original languageEnglish
Pages (from-to)292-298
Number of pages7
JournalJournal of Surgical Oncology
Volume104
Issue number3
DOIs
Publication statusPublished - Sep 1 2011

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Hepatocellular Carcinoma
Liver
Portal Vein
Thrombosis
Therapeutics
Survival Rate
Morbidity
Survival
Mortality

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Yamashita, Y. I., Taketomi, A., Shirabe, K., Aishima, S., Tsuijita, E., Morita, K., ... Maehara, Y. (2011). Outcomes of hepatic resection for huge hepatocellular carcinoma (a≥10cm in diameter). Journal of Surgical Oncology, 104(3), 292-298. https://doi.org/10.1002/jso.21931

Outcomes of hepatic resection for huge hepatocellular carcinoma (a≥10cm in diameter). / Yamashita, Yo Ichi; Taketomi, Akinobu; Shirabe, Ken; Aishima, Shinichi; Tsuijita, Eiji; Morita, Kazutoyo; Kayashima, Hiroto; Maehara, Yoshihiko.

In: Journal of Surgical Oncology, Vol. 104, No. 3, 01.09.2011, p. 292-298.

Research output: Contribution to journalReview article

Yamashita, YI, Taketomi, A, Shirabe, K, Aishima, S, Tsuijita, E, Morita, K, Kayashima, H & Maehara, Y 2011, 'Outcomes of hepatic resection for huge hepatocellular carcinoma (a≥10cm in diameter)', Journal of Surgical Oncology, vol. 104, no. 3, pp. 292-298. https://doi.org/10.1002/jso.21931
Yamashita YI, Taketomi A, Shirabe K, Aishima S, Tsuijita E, Morita K et al. Outcomes of hepatic resection for huge hepatocellular carcinoma (a≥10cm in diameter). Journal of Surgical Oncology. 2011 Sep 1;104(3):292-298. https://doi.org/10.1002/jso.21931
Yamashita, Yo Ichi ; Taketomi, Akinobu ; Shirabe, Ken ; Aishima, Shinichi ; Tsuijita, Eiji ; Morita, Kazutoyo ; Kayashima, Hiroto ; Maehara, Yoshihiko. / Outcomes of hepatic resection for huge hepatocellular carcinoma (a≥10cm in diameter). In: Journal of Surgical Oncology. 2011 ; Vol. 104, No. 3. pp. 292-298.
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N2 - Background The object of the current study was to review the outcomes of hepatic resection for hepatocellular carcinoma (HCC)10cm. Methods Between 1995 and 2007, fifty-three patients with HCC-0cm underwent hepatic resection, and clinical data were compared to those of patients with non-surgical treatment (n=12). Surgical results for HCC-10cm were compared to those of patients with HCC<10cm (n=412). The independent poor prognostic factors of the patients with HCC-10cm were identified. Results Overall survival was significantly better in patients with hepatic resection for HCC-10cm than in those with non-surgical treatment (P<0.01). Survival rates of patients with hepatic resection for HCC-10cm were 35% at 5 years. Morbidity and mortality rate were statistically equal. The independent poor prognostic factors of patients with hepatic resection for HCC-10cm were revealed: T4 status, macroscopic tumor thrombus in portal vein (VP+), and the use of intra-operative transfusion. Conclusion Hepatic resections for HCC-10cm are safe and efficacious. Minimizing intra-operative blood loss and the establishment of an effective systemic treatment for patients with HCC-10cm in T4 appear to be critical.

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