TY - JOUR
T1 - Ovarian endometrioid adenocarcinoma arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy for breast cancer
T2 - A case report
AU - Okugawa, Kaoru
AU - Hirakawa, Toshio
AU - Ogawa, Shinji
AU - Kaku, Tsunehisa
AU - Nakano, Hitoo
N1 - Funding Information:
We thank Ms. Linda Saza for help with manuscript preparation and Ms. Mieko Ogawa for technical assistance. This work was supported in part by Grants-in-Aid for Scientific Research (C) from the Ministry of Education, Culture, Sports, Science and Technology, Japan (No. 12671612 and No. 11671626).
PY - 2002
Y1 - 2002
N2 - Background. Ovarian cancer arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy is rare. Case. We herein report the case of a 67-year-old woman with a history of breast cancer, taking tamoxifen citrate 20 mg/day for 4 years, who underwent an operation for left ovarian tumor. The postoperative histological diagnosis was endometrioid adenocarcinoma in an endometriotic cyst with a gradual transition of the degree of cellular atypia noted from typical endometriotic epithelium, to atypical endometriosis, and finally to adenocarcinoma. Conclusion. Tamoxifen may cause malignant transformation of endometriosis through atypical endometriosis even in the post-menopausal state. Atypical endometriosis may act as a precancerous lesion in the process of tamoxifen-induced malignant transformation of endometriosis.
AB - Background. Ovarian cancer arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy is rare. Case. We herein report the case of a 67-year-old woman with a history of breast cancer, taking tamoxifen citrate 20 mg/day for 4 years, who underwent an operation for left ovarian tumor. The postoperative histological diagnosis was endometrioid adenocarcinoma in an endometriotic cyst with a gradual transition of the degree of cellular atypia noted from typical endometriotic epithelium, to atypical endometriosis, and finally to adenocarcinoma. Conclusion. Tamoxifen may cause malignant transformation of endometriosis through atypical endometriosis even in the post-menopausal state. Atypical endometriosis may act as a precancerous lesion in the process of tamoxifen-induced malignant transformation of endometriosis.
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U2 - 10.1006/gyno.2002.6824
DO - 10.1006/gyno.2002.6824
M3 - Article
C2 - 12477460
AN - SCOPUS:0036927697
SN - 0090-8258
VL - 87
SP - 231
EP - 234
JO - Gynecologic Oncology
JF - Gynecologic Oncology
IS - 2
ER -
