Ovarian endometrioid adenocarcinoma arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy for breast cancer: A case report

Kaoru Okugawa, Toshio Hirakawa, Shinji Ogawa, Tsunehisa Kaku, Hitoo Nakano

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22 Citations (Scopus)

Abstract

Background. Ovarian cancer arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy is rare. Case. We herein report the case of a 67-year-old woman with a history of breast cancer, taking tamoxifen citrate 20 mg/day for 4 years, who underwent an operation for left ovarian tumor. The postoperative histological diagnosis was endometrioid adenocarcinoma in an endometriotic cyst with a gradual transition of the degree of cellular atypia noted from typical endometriotic epithelium, to atypical endometriosis, and finally to adenocarcinoma. Conclusion. Tamoxifen may cause malignant transformation of endometriosis through atypical endometriosis even in the post-menopausal state. Atypical endometriosis may act as a precancerous lesion in the process of tamoxifen-induced malignant transformation of endometriosis.

Original languageEnglish
Pages (from-to)231-234
Number of pages4
JournalGynecologic Oncology
Volume87
Issue number2
DOIs
Publication statusPublished - Jan 1 2002

All Science Journal Classification (ASJC) codes

  • Oncology
  • Obstetrics and Gynaecology

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