Ovarian endometriosis associated with ovarian carcinoma

A clinicopathological and immunohistochemical study

Shinji Ogawa, Tsunehisa Kaku, Satoshi Amada, Hiroaki Kobayashi, Toshio Hirakawa, Kazuya Ariyoshi, Toshiharu Kamura, Hitoo Nakano

Research output: Contribution to journalArticle

206 Citations (Scopus)

Abstract

Objective. The purpose of this study was to demonstrate the incidence, the histopathological characteristics, and the proliferation activity of endometriosis and atypical endometriosis associated with ovarian carcinoma. Methods. Microscopic slides of primary lesions from 127 patients with primary ovarian carcinoma were reviewed. The presence or absence of endometriosis and the transitions from typical endometriosis to atypical endometriosis and from atypical endometriosis to carcinoma were also histologically evaluated. Ki-67 immunoreactivity of typical and atypical endometriosis and carcinoma was examined. In addition, endometrial metaplasias were also evaluated. Results. Of the 127 patients, 37 had endometriosis: 70% (30/43) had clear cell adenocarcinoma, 43% (3/7) had endometrioid adenocarcinoma, 7% (4/60) had serous adenocarcinoma, and none (0/17) had mucinous adenocarcinoma. Thirty- three cases showed typical endometriosis and 29 cases had atypical endometriosis (25 cases had both). Tufting and the stratification of the lining epithelium were observed in 25 and 23 cases, respectively. The transition from typical endometriosis to atypical endometriosis was observed in 22 cases, and the transition from atypical endometriosis to carcinoma, in 23 cases. Only one case showed a direct transition from typical endometriosis to carcinoma. The mean Ki-67 indices were as follows: ovarian carcinoma, 23.1; atypical endometriosis, 9.9; typical endometriosis, 2.7. In 18 cases with metaplasia in endometriosis, eosinophilic metaplasia and ciliated metaplasia were the most common types. Five cases had two types of metaplasia. Conclusions. Ovarian carcinomas, especially clear cell and endometrioid adenocarcinomas, are highly associated with endometriosis. Atypical endometriosis shows proliferation activity intermediate to those of typical endometriosis and ovarian carcinoma, suggesting it is a precancerous status. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)298-304
Number of pages7
JournalGynecologic Oncology
Volume77
Issue number2
DOIs
Publication statusPublished - Jan 1 2000

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Endometriosis
Carcinoma
Metaplasia
Clear Cell Adenocarcinoma
Endometrioid Carcinoma
Mucinous Adenocarcinoma

All Science Journal Classification (ASJC) codes

  • Oncology
  • Obstetrics and Gynaecology

Cite this

Ogawa, S., Kaku, T., Amada, S., Kobayashi, H., Hirakawa, T., Ariyoshi, K., ... Nakano, H. (2000). Ovarian endometriosis associated with ovarian carcinoma: A clinicopathological and immunohistochemical study. Gynecologic Oncology, 77(2), 298-304. https://doi.org/10.1006/gyno.2000.5765

Ovarian endometriosis associated with ovarian carcinoma : A clinicopathological and immunohistochemical study. / Ogawa, Shinji; Kaku, Tsunehisa; Amada, Satoshi; Kobayashi, Hiroaki; Hirakawa, Toshio; Ariyoshi, Kazuya; Kamura, Toshiharu; Nakano, Hitoo.

In: Gynecologic Oncology, Vol. 77, No. 2, 01.01.2000, p. 298-304.

Research output: Contribution to journalArticle

Ogawa, S, Kaku, T, Amada, S, Kobayashi, H, Hirakawa, T, Ariyoshi, K, Kamura, T & Nakano, H 2000, 'Ovarian endometriosis associated with ovarian carcinoma: A clinicopathological and immunohistochemical study', Gynecologic Oncology, vol. 77, no. 2, pp. 298-304. https://doi.org/10.1006/gyno.2000.5765
Ogawa, Shinji ; Kaku, Tsunehisa ; Amada, Satoshi ; Kobayashi, Hiroaki ; Hirakawa, Toshio ; Ariyoshi, Kazuya ; Kamura, Toshiharu ; Nakano, Hitoo. / Ovarian endometriosis associated with ovarian carcinoma : A clinicopathological and immunohistochemical study. In: Gynecologic Oncology. 2000 ; Vol. 77, No. 2. pp. 298-304.
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N2 - Objective. The purpose of this study was to demonstrate the incidence, the histopathological characteristics, and the proliferation activity of endometriosis and atypical endometriosis associated with ovarian carcinoma. Methods. Microscopic slides of primary lesions from 127 patients with primary ovarian carcinoma were reviewed. The presence or absence of endometriosis and the transitions from typical endometriosis to atypical endometriosis and from atypical endometriosis to carcinoma were also histologically evaluated. Ki-67 immunoreactivity of typical and atypical endometriosis and carcinoma was examined. In addition, endometrial metaplasias were also evaluated. Results. Of the 127 patients, 37 had endometriosis: 70% (30/43) had clear cell adenocarcinoma, 43% (3/7) had endometrioid adenocarcinoma, 7% (4/60) had serous adenocarcinoma, and none (0/17) had mucinous adenocarcinoma. Thirty- three cases showed typical endometriosis and 29 cases had atypical endometriosis (25 cases had both). Tufting and the stratification of the lining epithelium were observed in 25 and 23 cases, respectively. The transition from typical endometriosis to atypical endometriosis was observed in 22 cases, and the transition from atypical endometriosis to carcinoma, in 23 cases. Only one case showed a direct transition from typical endometriosis to carcinoma. The mean Ki-67 indices were as follows: ovarian carcinoma, 23.1; atypical endometriosis, 9.9; typical endometriosis, 2.7. In 18 cases with metaplasia in endometriosis, eosinophilic metaplasia and ciliated metaplasia were the most common types. Five cases had two types of metaplasia. Conclusions. Ovarian carcinomas, especially clear cell and endometrioid adenocarcinomas, are highly associated with endometriosis. Atypical endometriosis shows proliferation activity intermediate to those of typical endometriosis and ovarian carcinoma, suggesting it is a precancerous status. (C) 2000 Academic Press.

AB - Objective. The purpose of this study was to demonstrate the incidence, the histopathological characteristics, and the proliferation activity of endometriosis and atypical endometriosis associated with ovarian carcinoma. Methods. Microscopic slides of primary lesions from 127 patients with primary ovarian carcinoma were reviewed. The presence or absence of endometriosis and the transitions from typical endometriosis to atypical endometriosis and from atypical endometriosis to carcinoma were also histologically evaluated. Ki-67 immunoreactivity of typical and atypical endometriosis and carcinoma was examined. In addition, endometrial metaplasias were also evaluated. Results. Of the 127 patients, 37 had endometriosis: 70% (30/43) had clear cell adenocarcinoma, 43% (3/7) had endometrioid adenocarcinoma, 7% (4/60) had serous adenocarcinoma, and none (0/17) had mucinous adenocarcinoma. Thirty- three cases showed typical endometriosis and 29 cases had atypical endometriosis (25 cases had both). Tufting and the stratification of the lining epithelium were observed in 25 and 23 cases, respectively. The transition from typical endometriosis to atypical endometriosis was observed in 22 cases, and the transition from atypical endometriosis to carcinoma, in 23 cases. Only one case showed a direct transition from typical endometriosis to carcinoma. The mean Ki-67 indices were as follows: ovarian carcinoma, 23.1; atypical endometriosis, 9.9; typical endometriosis, 2.7. In 18 cases with metaplasia in endometriosis, eosinophilic metaplasia and ciliated metaplasia were the most common types. Five cases had two types of metaplasia. Conclusions. Ovarian carcinomas, especially clear cell and endometrioid adenocarcinomas, are highly associated with endometriosis. Atypical endometriosis shows proliferation activity intermediate to those of typical endometriosis and ovarian carcinoma, suggesting it is a precancerous status. (C) 2000 Academic Press.

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