Ovarian mucinous cystadenocarcinoma with sarcoma-appearing mural nodule of anaplastic carcinoma

Nobuhiro Tsuruchi, Tsunehisa Kaku, Hideichiro Kinoshita, Satoshi Amada, Toshiaki Saito, Toshiharu Kamura, Naoki Tsukamoto, Hitoo Nakano

Research output: Contribution to journalArticle

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Abstract

An ovarian mucinous cystadenocarcinoma with sarcoma-appearing solid mural nodules in an 18-year-old Japanese woman is reported. Right ovarian cyst had two poorly circumscribed, solid nodules and several tiny studs. Microscopically, the epithelial elements consisted of benign, low malignant potential and malignant mucinous tumors. The mural nodules were made up of highly malignant anaplastic cells simulating sarcoma. In one of the mural nodules, continuity between the malignant mucinous cells and sarcoma- appearing cells was identified. Immunohistochemically, the sarcoma-appearing nodule was uniformly positive for vimentin and focally positive for epithelial markers such as EMA, CAM5.2, and AE1/AE3. This case demonstrated an orderly transformation and dedifferentiation of epithelial cells to undifferentiated mesenchymal cells. Although she had stage IIb disease, she lived disease free for 3 years and 5 months after surgery followed by 10 courses of chemotherapy containing cisplatin and Adriamycin.

Original languageEnglish
Pages (from-to)259-263
Number of pages5
JournalGynecologic Oncology
Volume50
Issue number2
DOIs
Publication statusPublished - Jan 1 1993

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Mucinous Cystadenocarcinoma
Sarcoma
Carcinoma
Ovarian Cysts
Vimentin
Doxorubicin
Cisplatin
Epithelial Cells
Drug Therapy
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Obstetrics and Gynaecology

Cite this

Tsuruchi, N., Kaku, T., Kinoshita, H., Amada, S., Saito, T., Kamura, T., ... Nakano, H. (1993). Ovarian mucinous cystadenocarcinoma with sarcoma-appearing mural nodule of anaplastic carcinoma. Gynecologic Oncology, 50(2), 259-263. https://doi.org/10.1006/gyno.1993.1204

Ovarian mucinous cystadenocarcinoma with sarcoma-appearing mural nodule of anaplastic carcinoma. / Tsuruchi, Nobuhiro; Kaku, Tsunehisa; Kinoshita, Hideichiro; Amada, Satoshi; Saito, Toshiaki; Kamura, Toshiharu; Tsukamoto, Naoki; Nakano, Hitoo.

In: Gynecologic Oncology, Vol. 50, No. 2, 01.01.1993, p. 259-263.

Research output: Contribution to journalArticle

Tsuruchi, N, Kaku, T, Kinoshita, H, Amada, S, Saito, T, Kamura, T, Tsukamoto, N & Nakano, H 1993, 'Ovarian mucinous cystadenocarcinoma with sarcoma-appearing mural nodule of anaplastic carcinoma', Gynecologic Oncology, vol. 50, no. 2, pp. 259-263. https://doi.org/10.1006/gyno.1993.1204
Tsuruchi, Nobuhiro ; Kaku, Tsunehisa ; Kinoshita, Hideichiro ; Amada, Satoshi ; Saito, Toshiaki ; Kamura, Toshiharu ; Tsukamoto, Naoki ; Nakano, Hitoo. / Ovarian mucinous cystadenocarcinoma with sarcoma-appearing mural nodule of anaplastic carcinoma. In: Gynecologic Oncology. 1993 ; Vol. 50, No. 2. pp. 259-263.
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