Over-expression of p53 protein in esophageal squamous cell carcinoma of women

Tadahiro Nozoe, Yoshihiko Maehara

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background/Aims: Most physicians naturally accept the etiological aspect that the incidence of esophageal squamous cell carcinoma (ESCC) is excessively more frequent in men than that in women. However, a definitely scientific confirmation to explain it has not been found. In the current study, we investigated the relationship between gender and p53 over-expression, which might resolve the difference between the genders in the mechanism for carcinogenesis in ESCC. Methodology: Immunohistochemical expression of p53 was examined for 134 ESCCs, and the correlation of the gender with the clinicopathologic features and over-expression of p53 was compared. Results: The proportion of p53 over-expression in women was 23.8% (5 out of 21) and this incidence proportion was significantly lower than that in men (48.7%, 55 out of 113; p=0.031). Conclusions: This biological modulation might be correlated with the lower incidence of ESCC in women.

Original languageEnglish
Pages (from-to)73-76
Number of pages4
JournalHepato-Gastroenterology
Volume53
Issue number67
Publication statusPublished - Jan 1 2006

Fingerprint

Incidence
Proteins
Carcinogenesis
Physicians
Esophageal Squamous Cell Carcinoma

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Over-expression of p53 protein in esophageal squamous cell carcinoma of women. / Nozoe, Tadahiro; Maehara, Yoshihiko.

In: Hepato-Gastroenterology, Vol. 53, No. 67, 01.01.2006, p. 73-76.

Research output: Contribution to journalArticle

Nozoe, Tadahiro ; Maehara, Yoshihiko. / Over-expression of p53 protein in esophageal squamous cell carcinoma of women. In: Hepato-Gastroenterology. 2006 ; Vol. 53, No. 67. pp. 73-76.
@article{307d3ee58f0c48c3b75491ecaa9801da,
title = "Over-expression of p53 protein in esophageal squamous cell carcinoma of women",
abstract = "Background/Aims: Most physicians naturally accept the etiological aspect that the incidence of esophageal squamous cell carcinoma (ESCC) is excessively more frequent in men than that in women. However, a definitely scientific confirmation to explain it has not been found. In the current study, we investigated the relationship between gender and p53 over-expression, which might resolve the difference between the genders in the mechanism for carcinogenesis in ESCC. Methodology: Immunohistochemical expression of p53 was examined for 134 ESCCs, and the correlation of the gender with the clinicopathologic features and over-expression of p53 was compared. Results: The proportion of p53 over-expression in women was 23.8{\%} (5 out of 21) and this incidence proportion was significantly lower than that in men (48.7{\%}, 55 out of 113; p=0.031). Conclusions: This biological modulation might be correlated with the lower incidence of ESCC in women.",
author = "Tadahiro Nozoe and Yoshihiko Maehara",
year = "2006",
month = "1",
day = "1",
language = "English",
volume = "53",
pages = "73--76",
journal = "Acta hepato-splenologica",
issn = "0172-6390",
publisher = "H.G.E. Update Medical Publishing Ltd.",
number = "67",

}

TY - JOUR

T1 - Over-expression of p53 protein in esophageal squamous cell carcinoma of women

AU - Nozoe, Tadahiro

AU - Maehara, Yoshihiko

PY - 2006/1/1

Y1 - 2006/1/1

N2 - Background/Aims: Most physicians naturally accept the etiological aspect that the incidence of esophageal squamous cell carcinoma (ESCC) is excessively more frequent in men than that in women. However, a definitely scientific confirmation to explain it has not been found. In the current study, we investigated the relationship between gender and p53 over-expression, which might resolve the difference between the genders in the mechanism for carcinogenesis in ESCC. Methodology: Immunohistochemical expression of p53 was examined for 134 ESCCs, and the correlation of the gender with the clinicopathologic features and over-expression of p53 was compared. Results: The proportion of p53 over-expression in women was 23.8% (5 out of 21) and this incidence proportion was significantly lower than that in men (48.7%, 55 out of 113; p=0.031). Conclusions: This biological modulation might be correlated with the lower incidence of ESCC in women.

AB - Background/Aims: Most physicians naturally accept the etiological aspect that the incidence of esophageal squamous cell carcinoma (ESCC) is excessively more frequent in men than that in women. However, a definitely scientific confirmation to explain it has not been found. In the current study, we investigated the relationship between gender and p53 over-expression, which might resolve the difference between the genders in the mechanism for carcinogenesis in ESCC. Methodology: Immunohistochemical expression of p53 was examined for 134 ESCCs, and the correlation of the gender with the clinicopathologic features and over-expression of p53 was compared. Results: The proportion of p53 over-expression in women was 23.8% (5 out of 21) and this incidence proportion was significantly lower than that in men (48.7%, 55 out of 113; p=0.031). Conclusions: This biological modulation might be correlated with the lower incidence of ESCC in women.

UR - http://www.scopus.com/inward/record.url?scp=33344459099&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33344459099&partnerID=8YFLogxK

M3 - Article

C2 - 16506379

AN - SCOPUS:33344459099

VL - 53

SP - 73

EP - 76

JO - Acta hepato-splenologica

JF - Acta hepato-splenologica

SN - 0172-6390

IS - 67

ER -