Overexpression of angiotensin-converting enzyme in myelomonocytic cells enhances the immune response

Kenneth E. Bernstein, Zakir Khan, Jorge F. Giani, Tuantuan Zhao, Masahiro Eriguchi, Ellen A. Bernstein, Romer A. Gonzalez-Villalobos, Xiao Z. Shen

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)

Abstract

Angiotensin-converting enzyme (ACE) converts angiotensin I to the vasoconstrictor angiotensin II and thereby plays an important role in blood pressure control. However, ACE is relatively non-specific in its substrate specificity and cleaves many other peptides. Recent analysis of mice overexpressing ACE in monocytes, macrophages, and other myelomonocytic cells shows that these animals have a marked increase in resistance to experimental melanoma and to infection by Listeria monocytogenes or methicillin-resistant Staphylococcus aureus (MRSA). Several other measures of immune responsiveness, including antibody production, are enhanced in these animals. These studies complement a variety of studies indicating an important role of ACE in the immune response.

Original languageEnglish
Article number7508.1
JournalF1000Research
Volume5
DOIs
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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