Overexpression of angiotensin-converting enzyme in myelomonocytic cells enhances the immune response

Kenneth E. Bernstein, Zakir Khan, Jorge F. Giani, Tuantuan Zhao, Masahiro Eriguchi, Ellen A. Bernstein, Romer A. Gonzalez-Villalobos, Xiao Z. Shen

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Angiotensin-converting enzyme (ACE) converts angiotensin I to the vasoconstrictor angiotensin II and thereby plays an important role in blood pressure control. However, ACE is relatively non-specific in its substrate specificity and cleaves many other peptides. Recent analysis of mice overexpressing ACE in monocytes, macrophages, and other myelomonocytic cells shows that these animals have a marked increase in resistance to experimental melanoma and to infection by Listeria monocytogenes or methicillin-resistant Staphylococcus aureus (MRSA). Several other measures of immune responsiveness, including antibody production, are enhanced in these animals. These studies complement a variety of studies indicating an important role of ACE in the immune response.

Original languageEnglish
Article number7508.1
JournalF1000Research
Volume5
DOIs
Publication statusPublished - Jan 1 2016

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Peptidyl-Dipeptidase A
Animals
Listeria
Angiotensin I
Experimental Melanomas
Methicillin
Pressure control
Macrophages
Blood pressure
Listeria monocytogenes
Vasoconstrictor Agents
Methicillin-Resistant Staphylococcus aureus
Substrate Specificity
Angiotensin II
Antibody Formation
Monocytes
Blood Pressure
Peptides
Antibodies
Substrates

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Bernstein, K. E., Khan, Z., Giani, J. F., Zhao, T., Eriguchi, M., Bernstein, E. A., ... Shen, X. Z. (2016). Overexpression of angiotensin-converting enzyme in myelomonocytic cells enhances the immune response. F1000Research, 5, [7508.1]. https://doi.org/10.12688/f1000research.7508.1

Overexpression of angiotensin-converting enzyme in myelomonocytic cells enhances the immune response. / Bernstein, Kenneth E.; Khan, Zakir; Giani, Jorge F.; Zhao, Tuantuan; Eriguchi, Masahiro; Bernstein, Ellen A.; Gonzalez-Villalobos, Romer A.; Shen, Xiao Z.

In: F1000Research, Vol. 5, 7508.1, 01.01.2016.

Research output: Contribution to journalReview article

Bernstein, KE, Khan, Z, Giani, JF, Zhao, T, Eriguchi, M, Bernstein, EA, Gonzalez-Villalobos, RA & Shen, XZ 2016, 'Overexpression of angiotensin-converting enzyme in myelomonocytic cells enhances the immune response', F1000Research, vol. 5, 7508.1. https://doi.org/10.12688/f1000research.7508.1
Bernstein, Kenneth E. ; Khan, Zakir ; Giani, Jorge F. ; Zhao, Tuantuan ; Eriguchi, Masahiro ; Bernstein, Ellen A. ; Gonzalez-Villalobos, Romer A. ; Shen, Xiao Z. / Overexpression of angiotensin-converting enzyme in myelomonocytic cells enhances the immune response. In: F1000Research. 2016 ; Vol. 5.
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