Overexpression of hypoxia-inducible factor 1 α and p53 is a marker for an unfavorable prognosis in gastric cancer

Yasushi Sumiyoshi, Yoshihiro Kakeji, Akinori Egashira, Ken Mizokami, Hiroyuki Orita, Yoshihiko Maehara

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Abstract

Purpose: To investigate the effects of the expression of hypoxia-inducible factor 1α(HIF-1α) and p53 on the prognosis of human gastric cancer, the clinicopathologic characteristics of the tumors and the clinical outcome were analyzed. Experimental Design: The expressions of HIF-1α and p53 proteins were studied by immunohistochemistry in 216 specimens of primary gastric cancer. Results: HIF-1α(+)/p53(+) tumors more frequently showed an undifferentiated type, an infiltrative growth appearance, and an invasive lymphatic involvement compared with HIF-1α(-)/p53(-) tumors. HIF-1α(+)/p53(+) tumors also had more lymph node metastasis compared with HIF-1α(-)/p53(-) tumors. When stratified for HIF-1αand p53 positivity, the patients who were p53-negative and HIF-1α-negative had the most favorable prognosis, whereas patients who were p53-positive and HIF-1α-positive had the worst prognosis (P = 0.0018). Using a multivariate Cox regression analysis, the depth of invasion, lymph node metastasis, and HIF-1α positivity were all found to be independent prognostic factors in patients with gastric cancer. Conclusion: Thus, HIF-1α is considered to be a useful independent prognostic factor in gastric cancer, and the combination of a HIF-1α protein overexpression with nonfunctional p53 tends to indicate a dismal prognosis.

Original languageEnglish
Pages (from-to)5112-5117
Number of pages6
JournalClinical Cancer Research
Volume12
Issue number17
DOIs
Publication statusPublished - Sep 1 2006

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Hypoxia-Inducible Factor 1
Stomach Neoplasms
Neoplasms
Lymph Nodes
Neoplasm Metastasis
Proteins
Research Design
Immunohistochemistry
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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Overexpression of hypoxia-inducible factor 1 α and p53 is a marker for an unfavorable prognosis in gastric cancer. / Sumiyoshi, Yasushi; Kakeji, Yoshihiro; Egashira, Akinori; Mizokami, Ken; Orita, Hiroyuki; Maehara, Yoshihiko.

In: Clinical Cancer Research, Vol. 12, No. 17, 01.09.2006, p. 5112-5117.

Research output: Contribution to journalArticle

Sumiyoshi, Yasushi ; Kakeji, Yoshihiro ; Egashira, Akinori ; Mizokami, Ken ; Orita, Hiroyuki ; Maehara, Yoshihiko. / Overexpression of hypoxia-inducible factor 1 α and p53 is a marker for an unfavorable prognosis in gastric cancer. In: Clinical Cancer Research. 2006 ; Vol. 12, No. 17. pp. 5112-5117.
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AU - Orita, Hiroyuki

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