Overexpression of Id-1 is associated with tumor angiogenesis and poor clinical outcome in oral squamous cell carcinoma

Zuoqing Dong, Shaohua Liu, Chengjun Zhou, Tomoki sumida, Hiroyuki Hamakawa, Zhenggang Chen, Pei Liu, Fengcai Wei

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We analyzed the expression of Id-1 in oral squamous cell carcinoma (OSCC) immunohistochemically, and investigated the association of Id-1 expression with tumor angiogenesis and clinical prognosis. Overexpression of Id-1 protein was found in 83 out of 128 cases (64.8%). The expression of Id-1 was significantly associated with tumor size (p = 0.013), lymph node metastasis (p = 0.001), tumor stage (p = 0.031) and tumor recurrence (p = 0.003). Moreover, Id-1 expression was significantly correlated with intratumoral microvessel density (MVD) (r = 0.223, p = 0.011). The results suggest that overexpression of Id-1 was correlated with tumor angiogenesis and poor clinical outcome.

Original languageEnglish
Pages (from-to)154-157
Number of pages4
JournalOral Oncology
Volume46
Issue number3
DOIs
Publication statusPublished - Mar 1 2010

All Science Journal Classification (ASJC) codes

  • Oral Surgery
  • Oncology
  • Cancer Research

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