Overexpression of IL-15 in vivo enhances Tc1 response, which inhibits allergic inflammation in murine model of asthma

R. Ishimitsu, H. Nishimura, T. Yajima, T. Watase, H. Kawauchi, Yasunobu Yoshikai

    Research output: Contribution to journalArticle

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    Abstract

    IL-15, a pleiotropic cytokine, is involved in the inflammatory responses in various infectious and autoimmune diseases. We have recently constructed IL-154-transgenic (Tg) mice, which have an increased number of memory-type CD8+ T cells in the peripheral lymphoid tissues. In the present study, we found that eosinophilia and Th2-type cytokine production in the airway were severely attenuated in OVA-sensitized IL-15-Tg mice following OVA inhalation. IL-15-Tg mice preferentially developed Tc1 responses mediated by CD8+ T cells after OVA sensitization, and in vivo depletion of CD8+ T cells by anti-CD8 mAb aggravated the allergic airway inflammation in IL-15-Tg mice following OVA inhalation. Adoptive transfer of CD8+ T cells from OVA-sensitized IL-15-Tg mice into normal mice before OVA sensitization suppressed Th2, response to OVA in the normal mice. These results suggest that overexpression of IL-15 in vivo suppresses Th2-mediated-allergic airway response via induction of CD8+ T cell-mediated Tc1 response.

    Original languageEnglish
    Pages (from-to)1991-2001
    Number of pages11
    JournalJournal of Immunology
    Volume166
    Issue number3
    Publication statusPublished - Feb 1 2001

    Fingerprint

    Interleukin-15
    Asthma
    Inflammation
    T-Lymphocytes
    Inhalation
    Cytokines
    Adoptive Transfer
    Eosinophilia
    Lymphoid Tissue
    Transgenic Mice
    Autoimmune Diseases
    Communicable Diseases

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

    Cite this

    Ishimitsu, R., Nishimura, H., Yajima, T., Watase, T., Kawauchi, H., & Yoshikai, Y. (2001). Overexpression of IL-15 in vivo enhances Tc1 response, which inhibits allergic inflammation in murine model of asthma. Journal of Immunology, 166(3), 1991-2001.

    Overexpression of IL-15 in vivo enhances Tc1 response, which inhibits allergic inflammation in murine model of asthma. / Ishimitsu, R.; Nishimura, H.; Yajima, T.; Watase, T.; Kawauchi, H.; Yoshikai, Yasunobu.

    In: Journal of Immunology, Vol. 166, No. 3, 01.02.2001, p. 1991-2001.

    Research output: Contribution to journalArticle

    Ishimitsu, R, Nishimura, H, Yajima, T, Watase, T, Kawauchi, H & Yoshikai, Y 2001, 'Overexpression of IL-15 in vivo enhances Tc1 response, which inhibits allergic inflammation in murine model of asthma', Journal of Immunology, vol. 166, no. 3, pp. 1991-2001.
    Ishimitsu R, Nishimura H, Yajima T, Watase T, Kawauchi H, Yoshikai Y. Overexpression of IL-15 in vivo enhances Tc1 response, which inhibits allergic inflammation in murine model of asthma. Journal of Immunology. 2001 Feb 1;166(3):1991-2001.
    Ishimitsu, R. ; Nishimura, H. ; Yajima, T. ; Watase, T. ; Kawauchi, H. ; Yoshikai, Yasunobu. / Overexpression of IL-15 in vivo enhances Tc1 response, which inhibits allergic inflammation in murine model of asthma. In: Journal of Immunology. 2001 ; Vol. 166, No. 3. pp. 1991-2001.
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