Overexpression of IL-15 in vivo enhances Tc1 response, which inhibits allergic inflammation in murine model of asthma

R. Ishimitsu, H. Nishimura, T. Yajima, T. Watase, H. Kawauchi, Y. Yoshikai

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    58 Citations (Scopus)

    Abstract

    IL-15, a pleiotropic cytokine, is involved in the inflammatory responses in various infectious and autoimmune diseases. We have recently constructed IL-154-transgenic (Tg) mice, which have an increased number of memory-type CD8+ T cells in the peripheral lymphoid tissues. In the present study, we found that eosinophilia and Th2-type cytokine production in the airway were severely attenuated in OVA-sensitized IL-15-Tg mice following OVA inhalation. IL-15-Tg mice preferentially developed Tc1 responses mediated by CD8+ T cells after OVA sensitization, and in vivo depletion of CD8+ T cells by anti-CD8 mAb aggravated the allergic airway inflammation in IL-15-Tg mice following OVA inhalation. Adoptive transfer of CD8+ T cells from OVA-sensitized IL-15-Tg mice into normal mice before OVA sensitization suppressed Th2, response to OVA in the normal mice. These results suggest that overexpression of IL-15 in vivo suppresses Th2-mediated-allergic airway response via induction of CD8+ T cell-mediated Tc1 response.

    Original languageEnglish
    Pages (from-to)1991-2001
    Number of pages11
    JournalJournal of Immunology
    Volume166
    Issue number3
    DOIs
    Publication statusPublished - Feb 1 2001

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

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