Overexpression of interleukin-15 prevents the development of murine retrovirus-induced acquired immunodeficiency syndrome

Masayuki Umemura, Hitoshi Nishimura, Toshiki Yajima, Worawid Wajjwalk, Testuya Matsuguchi, Masahide Takahashi, Yukihiro Nishiyama, Masahiko Makino, Yoshiyuki Nagai, Yasunobu Yoshikai

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    13 Citations (Scopus)

    Abstract

    LP-BM5 murine leukemia virus (MuLV) infection causes murine acquired immunodeficiency syndrome (MAIDS), a disease characterized by varied functional abnormalities of immunocompetent cells. We found that MAIDS progression was severely retarded in IL-15 transgenic (Tg) mice constructed with cDNA encoding secretable IL-15 under the control of an MHC class I promoter. Several immune defects, including impaired natural killer activity, depressed IFN-γ production by T cells stimulated with anti-T cell receptor cross-linking, and increased susceptibility to Mycobacteium bovis infection, were prevented in IL-15 Tg mice inoculated with LP-BM5 MuLV. Cytotoxic T lymphocyte response to a highly antigenic 10-mer peptide encoded by LP-BM5-defective virus gag p12 gene was detected in the spleen and peritoneal exudate cells from IL-15 Tg mice infected with LP-BM5 MuLV. Intramuscular injection of cDNA encoding secretable IL-15 also prevented the development of MAIDS. These results indicate that IL-15 prevents the progression of MAIDS and may provide insight into an immunotherapeutic approach using the IL-15 gene for controlling retrovirus-induced immunodeficiency. - Umemura, M., Nishimura, H., Yajima, T., Wajjwalk, W., Matsuguchi, T., Takahashi, M., Nishiyama, Y., Makino, M., Nagai, Y., Yoshikai, Y. Overexpression of interleukin-15 prevents the development of murine retrovirus-induced acquired immunodeficiency syndrome.

    Original languageEnglish
    Pages (from-to)1755-1763
    Number of pages9
    JournalFASEB Journal
    Volume16
    Issue number13
    DOIs
    Publication statusPublished - Nov 2002

    All Science Journal Classification (ASJC) codes

    • Biotechnology
    • Biochemistry
    • Molecular Biology
    • Genetics

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