Overexpression of interleukin-15 prevents the development of murine retrovirus-induced acquired immunodeficiency syndrome

Masayuki Umemura, Hitoshi Nishimura, Toshiki Yajima, Worawid Wajjwalk, Testuya Matsuguchi, Masahide Takahashi, Yukihiro Nishiyama, Masahiko Makino, Yoshiyuki Nagai, Yasunobu Yoshikai

    Research output: Contribution to journalArticle

    13 Citations (Scopus)

    Abstract

    LP-BM5 murine leukemia virus (MuLV) infection causes murine acquired immunodeficiency syndrome (MAIDS), a disease characterized by varied functional abnormalities of immunocompetent cells. We found that MAIDS progression was severely retarded in IL-15 transgenic (Tg) mice constructed with cDNA encoding secretable IL-15 under the control of an MHC class I promoter. Several immune defects, including impaired natural killer activity, depressed IFN-γ production by T cells stimulated with anti-T cell receptor cross-linking, and increased susceptibility to Mycobacteium bovis infection, were prevented in IL-15 Tg mice inoculated with LP-BM5 MuLV. Cytotoxic T lymphocyte response to a highly antigenic 10-mer peptide encoded by LP-BM5-defective virus gag p12 gene was detected in the spleen and peritoneal exudate cells from IL-15 Tg mice infected with LP-BM5 MuLV. Intramuscular injection of cDNA encoding secretable IL-15 also prevented the development of MAIDS. These results indicate that IL-15 prevents the progression of MAIDS and may provide insight into an immunotherapeutic approach using the IL-15 gene for controlling retrovirus-induced immunodeficiency. - Umemura, M., Nishimura, H., Yajima, T., Wajjwalk, W., Matsuguchi, T., Takahashi, M., Nishiyama, Y., Makino, M., Nagai, Y., Yoshikai, Y. Overexpression of interleukin-15 prevents the development of murine retrovirus-induced acquired immunodeficiency syndrome.

    Original languageEnglish
    Pages (from-to)1755-1763
    Number of pages9
    JournalFASEB Journal
    Volume16
    Issue number13
    DOIs
    Publication statusPublished - Nov 1 2002

    Fingerprint

    Interleukin-15
    Retroviridae
    Acquired Immunodeficiency Syndrome
    Murine Acquired Immunodeficiency Syndrome
    Viruses
    Murine Leukemia Viruses
    Transgenic Mice
    T-cells
    Complementary DNA
    Genes
    gag Genes
    Defective Viruses
    Intramuscular Injections
    Cytotoxic T-Lymphocytes
    Exudates and Transudates
    Virus Diseases
    T-Cell Antigen Receptor
    Spleen
    T-Lymphocytes
    Defects

    All Science Journal Classification (ASJC) codes

    • Biotechnology
    • Biochemistry
    • Molecular Biology
    • Genetics

    Cite this

    Umemura, M., Nishimura, H., Yajima, T., Wajjwalk, W., Matsuguchi, T., Takahashi, M., ... Yoshikai, Y. (2002). Overexpression of interleukin-15 prevents the development of murine retrovirus-induced acquired immunodeficiency syndrome. FASEB Journal, 16(13), 1755-1763. https://doi.org/10.1096/fj.02-0274com

    Overexpression of interleukin-15 prevents the development of murine retrovirus-induced acquired immunodeficiency syndrome. / Umemura, Masayuki; Nishimura, Hitoshi; Yajima, Toshiki; Wajjwalk, Worawid; Matsuguchi, Testuya; Takahashi, Masahide; Nishiyama, Yukihiro; Makino, Masahiko; Nagai, Yoshiyuki; Yoshikai, Yasunobu.

    In: FASEB Journal, Vol. 16, No. 13, 01.11.2002, p. 1755-1763.

    Research output: Contribution to journalArticle

    Umemura, M, Nishimura, H, Yajima, T, Wajjwalk, W, Matsuguchi, T, Takahashi, M, Nishiyama, Y, Makino, M, Nagai, Y & Yoshikai, Y 2002, 'Overexpression of interleukin-15 prevents the development of murine retrovirus-induced acquired immunodeficiency syndrome', FASEB Journal, vol. 16, no. 13, pp. 1755-1763. https://doi.org/10.1096/fj.02-0274com
    Umemura, Masayuki ; Nishimura, Hitoshi ; Yajima, Toshiki ; Wajjwalk, Worawid ; Matsuguchi, Testuya ; Takahashi, Masahide ; Nishiyama, Yukihiro ; Makino, Masahiko ; Nagai, Yoshiyuki ; Yoshikai, Yasunobu. / Overexpression of interleukin-15 prevents the development of murine retrovirus-induced acquired immunodeficiency syndrome. In: FASEB Journal. 2002 ; Vol. 16, No. 13. pp. 1755-1763.
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    AU - Matsuguchi, Testuya

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