Overexpression of manganese superoxide dismutase mRNA may correlate with aggressiveness in gastric and colorectal adenocarcinomas.

Y. Toh, S. Kuninaka, T. Oshiro, Y. Ikeda, H. Nakashima, H. Baba, S. Kohnoe, T. Okamura, Masaki Mori, K. Sugimachi

Research output: Contribution to journalArticle

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Abstract

The expression or activity of manganese superoxide dismutase (Mn-SOD) is reduced in a variety of malignant tumors and Mn-SOD may act as a new type of tumor suppressor gene. On the other hand, increased expression of Mn-SOD can diminish the cytotoxic effects of several anticancer modalities, including tumor necrosis factor alpha, ionizing radiation, certain chemotherapeutic agents and hyperthermia. Although Mn-SOD expression and its role in various cancers are intensely studied, little is known about its function in gastrointestinal carcinomas. To examine the expression level and significance of Mn-SOD in gastrointestinal carcinomas, Mn-SOD mRNA expression was examined in 53 gastric carcinoma and 38 colorectal carcinoma by reverse transcription-polymerase chain reaction and was compared with those in the corresponding normal mucosal tissues. The tumor/normal (T/N) ratio was calculated and the data were clinicopathologically analyzed. The average T/N ratios of Mn-SOD mRNA expression in gastric and colorectal carcinomas were 2.19 and 3. 72, respectively. Clinicopathologic analyses revealed positive correlation between the Mn-SOD expression level and venous invasion in both gastric and colorectal carcinomas (p<0.05 and p<0.05, respectively). Furthermore, the colorectal carcinoma with lymph node metastasis showed significantly higher Mn-SOD expression than those without it (p<0.05). Our results suggest that Mn-SOD mRNA overexpression can occur in gastric and colorectal carcinomas and may be related to increased aggressiveness.

Original languageEnglish
Pages (from-to)107-112
Number of pages6
JournalInternational journal of oncology
Volume17
Issue number1
Publication statusPublished - Jan 1 2000

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Superoxide Dismutase
Stomach
Adenocarcinoma
Messenger RNA
Colorectal Neoplasms
Carcinoma
Neoplasms
Alpha Particles
Ionizing Radiation
Tumor Suppressor Genes
Reverse Transcription
Mucous Membrane
Fever
Tumor Necrosis Factor-alpha
Lymph Nodes
Neoplasm Metastasis
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Toh, Y., Kuninaka, S., Oshiro, T., Ikeda, Y., Nakashima, H., Baba, H., ... Sugimachi, K. (2000). Overexpression of manganese superoxide dismutase mRNA may correlate with aggressiveness in gastric and colorectal adenocarcinomas. International journal of oncology, 17(1), 107-112.

Overexpression of manganese superoxide dismutase mRNA may correlate with aggressiveness in gastric and colorectal adenocarcinomas. / Toh, Y.; Kuninaka, S.; Oshiro, T.; Ikeda, Y.; Nakashima, H.; Baba, H.; Kohnoe, S.; Okamura, T.; Mori, Masaki; Sugimachi, K.

In: International journal of oncology, Vol. 17, No. 1, 01.01.2000, p. 107-112.

Research output: Contribution to journalArticle

Toh, Y, Kuninaka, S, Oshiro, T, Ikeda, Y, Nakashima, H, Baba, H, Kohnoe, S, Okamura, T, Mori, M & Sugimachi, K 2000, 'Overexpression of manganese superoxide dismutase mRNA may correlate with aggressiveness in gastric and colorectal adenocarcinomas.', International journal of oncology, vol. 17, no. 1, pp. 107-112.
Toh, Y. ; Kuninaka, S. ; Oshiro, T. ; Ikeda, Y. ; Nakashima, H. ; Baba, H. ; Kohnoe, S. ; Okamura, T. ; Mori, Masaki ; Sugimachi, K. / Overexpression of manganese superoxide dismutase mRNA may correlate with aggressiveness in gastric and colorectal adenocarcinomas. In: International journal of oncology. 2000 ; Vol. 17, No. 1. pp. 107-112.
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