Overexpression of metastasis-associated MTA1 mRNA in invasive oesophageal carcinomas

Y. Toh, H. Kuwano, Masaki Mori, G. L. Nicolson, K. Sugimachi

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

The MTA1 gene is a recently identified novel candidate breast cancer metastasis-associated gene which has been implicated in the signal transduction or regulation of gene expression. We examined the mRNA expression levels of the MTA1, the human homologue of the rat mta1 gene in 47 surgically resected oesophageal squamous cell carcinomas by quantitative reverse transcription polymerase chain reaction. The relative overexpression of MTA1 mRNA (tumour/normal ratio ≥ 2) was observed in 16 out of 47 (34.0%) oesophageal carcinomas. Oesophageal tumours overexpressing MTA1 mRNA (T/N ratio ≥ 2) showed significantly higher frequencies of adventitial invasion (P < 0.05) and lymph node metastasis (P < 0.05), and tended to have a higher rate of lymphatic involvement than the remaining tumours. Thus, the data suggest that the MTA1 gene might play an important role in invasion and metastasis of oesophageal carcinomas.

Original languageEnglish
Pages (from-to)1723-1726
Number of pages4
JournalBritish journal of cancer
Volume79
Issue number11-12
DOIs
Publication statusPublished - Jan 1 1999

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Neoplasm Metastasis
Carcinoma
Messenger RNA
Genes
Adventitia
Neoplasms
Gene Expression Regulation
Reverse Transcription
Signal Transduction
Lymph Nodes
Breast Neoplasms
Polymerase Chain Reaction
Esophageal Squamous Cell Carcinoma

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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Overexpression of metastasis-associated MTA1 mRNA in invasive oesophageal carcinomas. / Toh, Y.; Kuwano, H.; Mori, Masaki; Nicolson, G. L.; Sugimachi, K.

In: British journal of cancer, Vol. 79, No. 11-12, 01.01.1999, p. 1723-1726.

Research output: Contribution to journalArticle

Toh, Y. ; Kuwano, H. ; Mori, Masaki ; Nicolson, G. L. ; Sugimachi, K. / Overexpression of metastasis-associated MTA1 mRNA in invasive oesophageal carcinomas. In: British journal of cancer. 1999 ; Vol. 79, No. 11-12. pp. 1723-1726.
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