Abstract
The MTA1 gene is a recently identified novel candidate breast cancer metastasis-associated gene which has been implicated in the signal transduction or regulation of gene expression. We examined the mRNA expression levels of the MTA1, the human homologue of the rat mta1 gene in 47 surgically resected oesophageal squamous cell carcinomas by quantitative reverse transcription polymerase chain reaction. The relative overexpression of MTA1 mRNA (tumour/normal ratio ≥ 2) was observed in 16 out of 47 (34.0%) oesophageal carcinomas. Oesophageal tumours overexpressing MTA1 mRNA (T/N ratio ≥ 2) showed significantly higher frequencies of adventitial invasion (P < 0.05) and lymph node metastasis (P < 0.05), and tended to have a higher rate of lymphatic involvement than the remaining tumours. Thus, the data suggest that the MTA1 gene might play an important role in invasion and metastasis of oesophageal carcinomas.
| Original language | English |
|---|---|
| Pages (from-to) | 1723-1726 |
| Number of pages | 4 |
| Journal | British journal of cancer |
| Volume | 79 |
| Issue number | 11-12 |
| DOIs | |
| Publication status | Published - Jan 1 1999 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
Cite this
Overexpression of metastasis-associated MTA1 mRNA in invasive oesophageal carcinomas. / Toh, Y.; Kuwano, H.; Mori, Masaki; Nicolson, G. L.; Sugimachi, K.
In: British journal of cancer, Vol. 79, No. 11-12, 01.01.1999, p. 1723-1726.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Overexpression of metastasis-associated MTA1 mRNA in invasive oesophageal carcinomas
AU - Toh, Y.
AU - Kuwano, H.
AU - Mori, Masaki
AU - Nicolson, G. L.
AU - Sugimachi, K.
PY - 1999/1/1
Y1 - 1999/1/1
N2 - The MTA1 gene is a recently identified novel candidate breast cancer metastasis-associated gene which has been implicated in the signal transduction or regulation of gene expression. We examined the mRNA expression levels of the MTA1, the human homologue of the rat mta1 gene in 47 surgically resected oesophageal squamous cell carcinomas by quantitative reverse transcription polymerase chain reaction. The relative overexpression of MTA1 mRNA (tumour/normal ratio ≥ 2) was observed in 16 out of 47 (34.0%) oesophageal carcinomas. Oesophageal tumours overexpressing MTA1 mRNA (T/N ratio ≥ 2) showed significantly higher frequencies of adventitial invasion (P < 0.05) and lymph node metastasis (P < 0.05), and tended to have a higher rate of lymphatic involvement than the remaining tumours. Thus, the data suggest that the MTA1 gene might play an important role in invasion and metastasis of oesophageal carcinomas.
AB - The MTA1 gene is a recently identified novel candidate breast cancer metastasis-associated gene which has been implicated in the signal transduction or regulation of gene expression. We examined the mRNA expression levels of the MTA1, the human homologue of the rat mta1 gene in 47 surgically resected oesophageal squamous cell carcinomas by quantitative reverse transcription polymerase chain reaction. The relative overexpression of MTA1 mRNA (tumour/normal ratio ≥ 2) was observed in 16 out of 47 (34.0%) oesophageal carcinomas. Oesophageal tumours overexpressing MTA1 mRNA (T/N ratio ≥ 2) showed significantly higher frequencies of adventitial invasion (P < 0.05) and lymph node metastasis (P < 0.05), and tended to have a higher rate of lymphatic involvement than the remaining tumours. Thus, the data suggest that the MTA1 gene might play an important role in invasion and metastasis of oesophageal carcinomas.
UR - http://www.scopus.com/inward/record.url?scp=0032999309&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032999309&partnerID=8YFLogxK
U2 - 10.1038/sj.bjc.6690274
DO - 10.1038/sj.bjc.6690274
M3 - Article
VL - 79
SP - 1723
EP - 1726
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
IS - 11-12
ER -