TY - JOUR
T1 - Overexpression of metastasis-associated MTA1 mRNA in invasive oesophageal carcinomas
AU - Toh, Y.
AU - Kuwano, H.
AU - Mori, M.
AU - Nicolson, G. L.
AU - Sugimachi, K.
N1 - Funding Information:
This work was supported in part by Research Grant of the Princess Takamatsu Cancer Research Fund and a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan to YT and a grant from the US National Institute of Health to GLN.
PY - 1999
Y1 - 1999
N2 - The MTA1 gene is a recently identified novel candidate breast cancer metastasis-associated gene which has been implicated in the signal transduction or regulation of gene expression. We examined the mRNA expression levels of the MTA1, the human homologue of the rat mta1 gene in 47 surgically resected oesophageal squamous cell carcinomas by quantitative reverse transcription polymerase chain reaction. The relative overexpression of MTA1 mRNA (tumour/normal ratio ≥ 2) was observed in 16 out of 47 (34.0%) oesophageal carcinomas. Oesophageal tumours overexpressing MTA1 mRNA (T/N ratio ≥ 2) showed significantly higher frequencies of adventitial invasion (P < 0.05) and lymph node metastasis (P < 0.05), and tended to have a higher rate of lymphatic involvement than the remaining tumours. Thus, the data suggest that the MTA1 gene might play an important role in invasion and metastasis of oesophageal carcinomas.
AB - The MTA1 gene is a recently identified novel candidate breast cancer metastasis-associated gene which has been implicated in the signal transduction or regulation of gene expression. We examined the mRNA expression levels of the MTA1, the human homologue of the rat mta1 gene in 47 surgically resected oesophageal squamous cell carcinomas by quantitative reverse transcription polymerase chain reaction. The relative overexpression of MTA1 mRNA (tumour/normal ratio ≥ 2) was observed in 16 out of 47 (34.0%) oesophageal carcinomas. Oesophageal tumours overexpressing MTA1 mRNA (T/N ratio ≥ 2) showed significantly higher frequencies of adventitial invasion (P < 0.05) and lymph node metastasis (P < 0.05), and tended to have a higher rate of lymphatic involvement than the remaining tumours. Thus, the data suggest that the MTA1 gene might play an important role in invasion and metastasis of oesophageal carcinomas.
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U2 - 10.1038/sj.bjc.6690274
DO - 10.1038/sj.bjc.6690274
M3 - Article
C2 - 10206283
AN - SCOPUS:0032999309
VL - 79
SP - 1723
EP - 1726
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
IS - 11-12
ER -
