Overexpression of p16(INK4a) in Mastocytosis (Urticarial Pigmentosa)

Jun Tsujita, Kazuko Doi, Makiko Nakahara, Takeshi Nakahara, Yumiko Kaku, Kiichiro Nishio, Nagisa Kan, Yuki Sato, Shoko Nagata, Asako Nakao, Maiko Yoshida, Uchi Hiroshi, Masutaka Furue

Research output: Contribution to journalArticlepeer-review

Abstract

The expression of p16(INK4a) has been reported to induce cell-cycle arrest and cellular senescence. The p16(INK4a) expression has never been examined in human mast cells and mastocytosis. We immunohistologically examined the expression of p16(INK4a) and tryptase in 5 normal human skin and 4 mastocytosis. In normal mast cells, only 5.9 ± 3.4 (mean ± standard deviation) % of tryptase-positive mast cells coexpressed p16(INK4a). However, significantly higher percentage (86.0 ± 14.1%) of tryptase-positive tumor cells was immunoreactive to p16(INK4a) in all of 4 mastocytosis. The p16(INK4a) overexpression may induce the senescence of neoplastic mast cells to undergo spontaneous regression of mastocytosis.

Original languageEnglish
Pages (from-to)12-17
Number of pages6
JournalFukuoka igaku zasshi = Hukuoka acta medica
Volume107
Issue number1
Publication statusPublished - Jan 1 2016

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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